Publications by authors named "Sun Jian-Le"
HO-1 is a rate-limiting enzyme in hemoglobin metabolism, and exerts anti-inflammatory as well as anti-apoptotic effects. Previous studies have shown that expression of HO-1 can prolong the survival of concordant transplanted organs. However, little is known about the precise effect and mechanism of HO-1 in discordant xenotransplantation.
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- Heme oxygenase-1 (HO-1) exhibits anti-inflammatory properties in asthma by enhancing the function of regulatory T cells (Treg) that help suppress immune responses.
- In experiments with different mouse groups, those treated with hemin showed lower allergic airway inflammation markers compared to other treatments, indicating that hemin is effective for reducing symptoms.
- The study suggests that HO-1 may exert its anti-inflammatory effects by increasing IL-10 levels and promoting Treg cells, although its effectiveness is diminished when Sn-protoporphyrin (SnPP) is administered.