The application prospects of sacha inchi ( linneo) in rheumatoid arthritis.

Sacha Inchi ( L) (SI) is a traditional natural medicine from tropical rainforests of Amazon region in South America. As a raw material for edible oil, it has various pharmacological effects such as antioxidant, anti-inflammatory, hypolipidemia, and blood pressure lowering, which have attracted increasing attentions of pharmacists. This has prompted researchers to explore its pharmacological effects for potential applications in certain diseases.

Investigating the determinants of homestay satisfaction on Airbnb using multiple techniques.

Peer-to-peer accommodation has gained prominence in the sharing economy and e-commerce sectors, with big data playing a crucial role in understanding customer preferences and evaluating homestay satisfaction. This study proposes a novel methodology that integrates Natural Language Processing (NLP) techniques, a Random Forest model, and Geographic Information System (GIS) functionalities to quantify the complex relationship between homestay satisfaction and diverse customer preferences. Notably, this study addresses the positive bias inherent in listing scores by segmenting homestays into three categories (satisfactory, moderate, and dissatisfactory) based on sentiment analysis from online reviews.

Optimization of Extraction Conditions for Water-Soluble Polysaccharides from the Roots of (Thunb.) Fisch. and Its Effects on Glucose Consumption on HepG2 Cells.

The root of (Thunb.) Fisch. is a common Chinese materia medica and the polysaccharides which have been isolated from the plant are important active components for medicinal purposes.

Coverage of the Combined DTaP-IPV/Hib Vaccine Among Children Aged 2-18 Months - 9 PLADs, China, 2019-2021.

What Is Already Known On This Topic?: In China, there is limited data available on the use and coverage of the non-program, combined diphtheria, tetanus toxoid, acellular pertussis adsorbed, inactivated poliovirus and haemophilus influenzae type b (DTaP-IPV/Hib) pentavalent vaccine, and its role as a substitute for the separately administered standalone program vaccines.

What Is Added By This Report?: We evaluated the use and coverage of the pentavalent vaccine in nine provincial-level administrative divisions (PLADs) spanning eastern, central, and western China from 2019 to 2021. Initial use and coverage were low, but demonstrated annual growth albeit with regional and urban-rural discrepancies.

A systematic review: Sinomenine.

Sinomenine (SIN), an alkaloid derived from the traditional Chinese medicine, , has been used as an anti-inflammatory drug in China for over 30 years. With the continuous increase in research on the pharmacological mechanism of SIN, it has been found that, in addition to the typical rheumatoid arthritis (RA) treatment, SIN can be used as a potentially effective therapeutic drug for anti-tumour, anti-renal, and anti-nervous system diseases. By reviewing a large amount of literature and conducting a summary analysis of the literature pertaining to the pharmacological mechanism of SIN, we completed a review that focused on SIN, found that the current research is insufficient, and offered an outlook for future SIN development.

Sinomenine Hydrochloride Protects IgA Nephropathy Through Regulating Cell Growth and Apoptosis of T and B Lymphocytes.

Purpose: Sinomenine hydrochloride (SH) is used to treat chronic inflammatory diseases such as rheumatoid arthritis and may also be efficacious against Immunoglobulin A nephropathy (IgAN). However, no trial has investigated the molecular mechanism of SH on IgAN. Therefore, this study aims to investigate the effect and mechanism of SH on IgAN.

SPARC: a potential target for functional nanomaterials and drugs.

Secreted protein acidic and rich in cysteine (SPARC), also termed osteonectin or BM-40, is a matricellular protein which regulates cell adhesion, extracellular matrix production, growth factor activity, and cell cycle. Although SPARC does not perform a structural function, it, however, modulates interactions between cells and the surrounding extracellular matrix due to its anti-proliferative and anti-adhesion properties. The overexpression of SPARC at sites, including injury, regeneration, obesity, cancer, and inflammation, reveals its application as a prospective target and therapeutic indicator in the treatment and assessment of disease.

Naringin Protects against Tau Hyperphosphorylation in A -Injured PC12 Cells through Modulation of ER, PI3K/AKT, and GSK-3 Signaling Pathways.

Alzheimer's disease (AD) is the most common form of dementia and a significant social and economic burden. Estrogens can exert neuroprotective effects and may contribute to the prevention, attenuation, or even delay in the onset of AD; however, long-term estrogen therapy is associated with harmful side effects. Thus, estrogen alternatives are of interest for countering AD.

The Dual Effect of 3D-Printed Biological Scaffolds Composed of Diverse Biomaterials in the Treatment of Bone Tumors.

Bone tumors, including primary bone tumors, invasive bone tumors, metastatic bone tumors, and others, are one of the most clinical difficulties in orthopedics. Once these tumors have grown and developed in the bone system, they will interact with osteocytes and other environmental cells in the bone system's microenvironment, leading to the eventual damage of the bone's physical structure. Surgical procedures for bone tumors may result in permanent defects.

Optimal nitrogen fertilizer, which determines straw properties, and pyrolysis temperatures produce desired-biochars that can be used as a soil amendment.

This study investigated the straw harvested after nitrogen (N) fertilizer application levels (0, 75, 150 and 225 kg N hm). The N fertilizer increased straw yield by 115.4-190.

A Deep Learning Method for Motion Artifact Correction in Intravascular Photoacoustic Image Sequence.

In vivo application of intravascular photoacoustic (IVPA) imaging for coronary arteries is hampered by motion artifacts associated with the cardiac cycle. Gating is a common strategy to mitigate motion artifacts. However, a large amount of diagnostically valuable information might be lost due to one frame per cycle.

Image reconstruction for endoscopic photoacoustic tomography including effects of detector responses.

In photoacoustic tomography (PAT), conventional image reconstruction methods are generally based on the assumption of an ideal point-like ultrasonic detector. This assumption is appropriate when the receiving surface of the detector is sufficiently small and/or the distance between the imaged object and the detector is large enough. However, it does not hold in endoscopic applications of PAT.

Tissue Distribution of Total Flavonoids Extracts of in Young and Old Rats by UPLC-MS/MS Determination.

(Kunze ex Mett.) J. Sm.

Root foraging of birch and larch in heterogeneous soil nutrient patches under water deficit.

Water and nutrient are two critical factors that limit plant growth to spatial-temporal extents. Tree root foraging behavior has not received adequate attention in heterogeneous soil environments in temperate forest under drought pressure. In this study, birch (Betula platyphylla) and larch (Larix olgensis) seedlings were raised in pots in a split-root system with artificially heterogeneous soil environments to study the root foraging response to drought.

Protective mechanism of kaempferol against Aβ-mediated apoptosis of pheochromocytoma (PC-12) cells through the ER/ERK/MAPK signalling pathway.

Introduction: Progressive accumulation of amyloid-β (Aβ) is a pathological trait of Alzheimer's disease (AD). Amyloid-β increases free radical production in neuronal cells, leading to neuronal cell death. Hormone replacement therapy can reduce the incidence of AD, and oestrogen significantly improves the clinical signs in patients with AD.

Nutrient removal, methane and nitrous oxide emissions in a hybrid constructed wetland treating anaerobic digestate.

A pilot hybrid constructed wetland (CW) planted with reeds (Phragmite australis) and rice (Oryza sativa L.) was designed to treat liquid anaerobic digestate in the Yangtze River Delta, China. The hybrid CW system was composed of four stages: two reed vegetated vertical subsurface flow beds (VSSF: U1 and U2) in sequence, followed by a reed vegetated horizontal subsurface flow bed (HSSF: U3) and a rice vegetated surface flow bed (SF: U4).

Long-term effects of straw return and straw-derived biochar amendment on bacterial communities in soil aggregates.

Improving soil structure, fertility, and production is of major concern for establishing sustainable agroecosystems. Further research is needed to evaluate whether different methods of straw returning determine the variations of soil aggregation and the microbial community in aggregates in the long term. In this study, we comparatively investigated the effects of long-term fertilization regimes performed over six years, namely, non-fertilization (CK), chemical fertilization (CF), continuous straw return (CS), and continuous straw-derived biochar amendment (CB), on soil aggregation and bacterial communities in rice-wheat rotation systems.

The soluble fraction from straw-derived biochar supplies nutrients and affects carbon storage of coastal mudflat soil in rice paddy.

Incorporation of biochar into soil has been proposed as a strategy for enhancing soil fertility and rice production. A pot trial was carried out to investigate the effects of the dissolvable fraction of biochar in the Yangtze River estuary, China. Soil in plastic pots was incorporated with straw biochar at five different rates: 0%, 5%, 10%, 15%, and 20% (w/wet weight).

Year-to-year climate variability affects methane emission from paddy fields under irrigated conditions.

A field experiment in Yangtze River delta of China was conducted to investigate the effects of four treatments (conventional chemical fertilizers (CF), chemical fertilizers incorporated with wheat straw (CF-WS), slow-release urea fertilizer incorporated with wheat straw (SCF-WS), and no fertilizers (Non-F)) on methane emission, rice grain yield, and straw biomass in three (2013, 2014, and 2015) consecutive growing seasons. Similar air temperature and precipitation were recorded in 2014 and 2015 normal seasons; however, the 2013 season with a 2.1-2.

Effect of moisture gradient on rice yields and greenhouse gas emissions from rice paddies.

Fluxes of methane (CH) and nitrous oxide (NO) from two rice varieties, Huayou 14 and Hanyou 8, were monitored using closed chamber/gas chromatography method. Huayou 14 is a commonly grown variety of rice whereas Hanyou 8 is a water-saving and drought-resistant rice (WDR) variety. Low soil volumetric water content (VWC) existed in the treatments on the slope (W5 < W4 < W3 < W2).

Effect of Straw and Straw Biochar on the Community Structure and Diversity of Ammonia-oxidizing Bacteria and Archaea in Rice-wheat Rotation Ecosystems.

Ammonia oxidation is the first and rate-limiting step of nitrification, driven by ammonia-oxidizing bacteria (AOB) and ammonia-oxidizing archaea (AOA). Straw and straw biochar retention are the popular ways to utilize the agricultural by-products in China, but their long-term effects on AOB and AOA still remain poorly understood. Based on a 7-year plot experiment, which had 4 fertilization regimes: no fertilizer (CK), regular fertilization (RT), straw retention (SR) and straw biochar retention (SB), the abundance and the composition of AOB and AOA was investigated before both the harvest of rice and wheat season by quantitative PCR and 454 high-throughput pyrosequencing, respectively.

Three-year rice grain yield responses to coastal mudflat soil properties amended with straw biochar.

Biochar application is a promising management strategy for enhancing soil fertility and carbon sequestration. A 3-year pot trial was conducted to demonstrate the relationship between rice grain yield and biochar-amended soil properties together with carbon storage in the Yangtze River estuary, China. Straw biochar was incorporated once into soil in pots at five different rates: 0%, 5%, 10%, 15%, and 20% (dry biochar weight/wet soil weight).

Long-term effects of straw and straw-derived biochar on soil aggregation and fungal community in a rice-wheat rotation system.

Background: Soil aggregation is fundamental for soil functioning and agricultural productivity. Aggregate formation depends on microbial activity influencing the production of exudates and hyphae, which in turn act as binding materials. Fungi are also important for improving soil quality and promoting plant growth in a symbiotic manner.

[Analysis on "component-target-pathway" of Paeonia lactiflora in treating cardiac diseases based on data mining].

Based on the literature review and modern application of Paeonia lactiflora in heart diseases, this article would predict the target of drug and disease by intergrative pharmacology platform of traditional Chinese medicine (TCMIP, http://www.tcmip.cn), and then explore the molecular mechanism of P.

Reducing N losses through surface runoff from rice-wheat rotation by improving fertilizer management.

To better understand N runoff losses from rice-wheat rotation and demonstrate the effectiveness of improved fertilizer management in reducing N runoff losses, a field study was conducted for three consecutive rice-wheat rotations. Nitrogen losses through surface runoff were measured for five treatments, including CK without N application, C200, C300 simulating the conventional practices, CO200, and CO300. Optimum N rate was applied for C200 and CO200, and 30% of chemical fertilizer was substituted with organic fertilizer for CO200 and CO300 with respect to C200 and C300, respectively.