Hierarchical deep learning for autonomous multi-label arrhythmia detection and classification on real-world wearable electrocardiogram data.

Objective: Arrhythmia detection and classification are challenging because of the imbalanced ratio of normal heartbeats to arrhythmia heartbeats and the complicated combinations of arrhythmia types. Arrhythmia classification on wearable electrocardiogram monitoring devices poses a further unique challenge: unlike clinically used electrocardiogram monitoring devices, the environments in which wearable devices are deployed are drastically different from the carefully controlled clinical environment, leading to significantly more noise, thus making arrhythmia classification more difficult.

Methods: We propose a novel hierarchical model based on CNN+BiLSTM with Attention to arrhythmia detection, consisting of a binary classification module between normal and arrhythmia heartbeats and a multi-label classification module for classifying arrhythmia events across combinations of beat and rhythm arrhythmia types.

Molecular diagnosis of patients with syndromic short stature identified by trio whole-exome sequencing.

Background: Short stature is a complex disorder with phenotypic and genetic heterogeneity. This study aimed to investigate clinical phenotypes and molecular basis of a cohort of patients with short stature.

Methods: Trio whole-exome sequencing (Trio-WES) was performed to explore the genetic aetiology and obtain a molecular diagnosis in twenty Chinese probands with syndromic and isolated short stature.

Dihydromyricetin ameliorate postmenopausal osteoporosis in ovariectomized mice: Integrative microbiomic and metabolomic analysis.

The gut microbiota may help mitigate bone loss linked to postmenopausal osteoporosis by affecting the immune and inflammatory responses and the gut-bone axis. Dihydromyricetin (DMY), a natural flavonoid, has some anti-inflammatory and antioxidant properties. This study aimed to investigate the mechanisms underlying the amelioration of bone loss in ovariectomized (OVX) mice treated with various doses of DMY.

Increased thyroid hormone sensitivity is correlated with visceral obesity in patients with type 2 diabetes.

Objective: The study aimed to assess whether thyroid hormone (TH) sensitivity is related to visceral fat area (VFA) and visceral obesity in euthyroid subjects with type 2 diabetes (T2D).

Methods: 750 euthyroid patients with T2D were enrolled. A VFA of 80 cm or more was considered visceral obesity.

The association between anion gap and length of stay in patients undergoing hip fracture surgery: data from the MIMIC-IV database.

Objective: To explore the relationship between anion gap (AG) and length of stay (LOS) in patients undergoing hip fracture surgery.

Methods: Clinical data of patients diagnosed with hip fracture and undergoing surgery were extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Logistic regression analysis by adjusting different covariables and threshold effect analysis were used to analyze the relationship between AG and LOS.

Agile manipulation of the time-frequency distribution of high-speed electromagnetic waves.

Controlling the temporal evolution of an electromagnetic (EM) wave's frequency components, the so-called time-frequency (TF) distribution, in a versatile and real-time fashion remains very challenging, especially at the high speeds (> GHz regime) required in contemporary communication, imaging, and sensing applications. We propose a general framework for manipulating the TF properties of high-speed EM waves. Specifically, the TF distribution is continuously mapped along the time domain through phase-only processing, enabling its user-defined manipulation via widely-available temporal modulation techniques.

Reduced Proline-Rich Tyrosine Kinase 2 Promotes Tumor Metastasis by Activating Epithelial-Mesenchymal Transition in Colorectal Cancer.

Background: Proline-rich tyrosine kinase 2 (PYK2) is involved in the occurrence, proliferation, migration, and invasion of various tumors. However, few studies have reported the role of PYK2 in colorectal cancer (CRC).

Aim: To explore the effects of PYK2 on CRC metastasis and elucidate the detailed molecular mechanisms involved.

Synergistic effects of dual reactive compatibilizers for high-performance fully biodegradable polylactic acid/poly (butyleneadipate-co-terephthalate) composites.

The PLA-g-(GMA-co-St) graft copolymer (PGS) was prepared using melt-free radical grafting technology, PGS and ESO were simultaneously employed as compatibilizers for the poly (lactic acid)/poly (butylene adipate-co-terephthalate) (PLA/PBAT) blends. The effects of the type and amount of compatibilizers on the properties of the blends were studied. The results reveal that the epoxy groups in PGS and ESO can interact with the terminal groups of PLA and PBAT.

Growth-coupled production of L-isoleucine in Escherichia coli via metabolic engineering.

L-isoleucine, an essential amino acid, is widely used in the pharmaceutical and food industries. However, the current production efficiency is insufficient to meet the increasing demands. In this study, we aimed to develop an efficient L-isoleucine-producing strain of Escherichia coli.

Non-volatile and Secure Optical Storage Medium with Multilevel Information Encryption.

Non-volatile photomemory based on photomodulated luminescent materials offers unique advantages over voltage-driven memory, including low residual crosstalk and high storage speed. However, conventional materials have thus far been volatile and insecure for data storage because of low trap depth and single-level storage channels. Therefore, the development of a novel non-volatile multilevel storage medium for data encryption remains a challenge.

Protective effect of the branched short-chain fatty acid isobutyrate on intestinal damage in weaned piglets through intestinal microbiota remodeling.

Background: Postweaning intestinal damage in piglets is a challenging issue in the livestock industry. Short-chain fatty acids (SCFAs) are important metabolic products of the gut microbiota and are widely recognized for their role in maintaining normal colonic function and regulating the intestinal immune system. However, the effects of branched short-chain fatty acid (BSCFA) isobutyrate on intestinal health remain largely unknown.

Intraperitoneal Chemotherapy without Bevacizumab versus Intravenous Chemotherapy with Bevacizumab as the Frontline Adjuvant Therapy in Advanced Ovarian Cancer.

To compare the clinical outcomes of intravenous carboplatin/paclitaxel chemotherapy plus bevacizumab versus intraperitoneal cisplatin/paclitaxel chemotherapy without bevacizumab as the frontline treatment in women with advanced ovarian, fallopian tube and primary peritoneal cancer. Between November 2012 and January 2024, medical records of all consecutive women with stage II~IV cancer treated with either frontline adjuvant intraperitoneal cisplatin/paclitaxel without bevacizumab (IP group), intravenous carboplatin/paclitaxel without bevacizumab (IV group) or intravenous carboplatin/paclitaxel with bevacizumab (IVB group) at a tertiary referral center were reviewed. A total of 143 women (IP group, n = 57; IVB group, n = 23; IV group, n = 63) were reviewed.

Experiment Study on Rock Mass Classification Based on RCM-Equipped Sensors and Diversified Ensemble-Learning Model.

The geological condition monitoring and identification based on TBM-equipped sensors is of great significance for efficient and safe tunnel construction. Full-scale rotary cutting experiments are carried out using tunnel-boring machine disc cutters. Thrust, torque and vibration sensors are equipped on the rotary cutting machine (RCM).

Transcriptomic Insights into the Atrial Fibrillation Susceptibility Locus near the and Genes.

Genome-wide association studies have identified a locus on chromosome 10q22, where many co-inherited single nucleotide polymorphisms (SNPs) are associated with atrial fibrillation (AF). This study seeks to identify the impact of this locus on gene expression at the transcript isoform level in human left atria and to gain insight into potential causal variants. Bulk RNA sequencing was analyzed to identify myozenin 1 () and synaptopodin 2-like () transcript isoforms and the association of common SNPs in this region with transcript isoform expression levels.

Dobinin K Displays Antiplasmodial Activity through Disruption of Mitochondria and Generation of Reactive Oxygen Species.

Dobinin K is a novel eudesmane sesquiterpenoids compound isolated from the root of and displays potential antiplasmodial activity in vivo. Here, we evaluate the antiplasmodial activity of dobinin K in vitro and study its acting mechanism. The antiplasmodial activity of dobinin K in vitro was evaluated by concentration-, time-dependent, and stage-specific parasite inhibition assay.

Does every transgender person want gender affirming surgery? A survey of transgender individuals in the Midwestern United States.

Gender-affirming surgery (GAS) is a highly personalized decision for transgender and gender diverse (TGD) individuals. However, the proportion of TGD individuals who desire GAS is unknown. A questionnaire was created after identifying themes surrounding experiences with gender-affirming medical care by community focus groups.

Modelling of enhanced gas extraction in low permeability coal seam by controllable shock wave fracturing.

The controlled shock wave (CSW) fracturing is an effective method for enhancing permeability of coal seam to promote gas extraction. Based on Fick's law, Darcy's law, the ideal gas law and the Langmuir equation, a damage-seepage-deformation coupling mathematical model of CSW fracturing in coal seam combined with the maximum tensile stress and the Mohr-Coulomb criterion is established. This model is implemented into COMSOL Multiphysics to simulate the coal seam CSW fracturing and subsequent gas extraction.