A new LNC89/LNC60-Col11a2 axis revealed by whole-transcriptome analysis may be associated with goiters related to excess iodine nutrition.

Goiter related to excessive iodine nutrition remains a significant public health issue in some countries. There has been no reported study on long noncoding RNAs (lncRNAs) related to goiters. In this study, goiter was induced by drinking water with excess iodine for 10 or 20 weeks in Kunming mice.

Engineering transcriptional regulatory networks for improving second-generation fuel ethanol production in .

Presently, demonstrates proficient co-fermentation of glucose and xylose, marking a significant advancement in second-generation fuel ethanol production. However, the presence of high concentrations of inhibitors in industrial lignocellulose hydrolysates and post-glucose effect caused by glucose consumption hinders severely impedes yeast robustness and xylose utilization for ethanol fermentation. Even worse, the antagonism between xylose utilization ability and strain robustness was observed, which proposes a difficult challenge in the production of second-generation fuel ethanol by .

Drug resistance mechanism of anti-angiogenesis therapy in tumor.

Angiogenesis refers to the process of forming a new network of blood vessels from existing ones through the migration, proliferation, and differentiation of endothelial cells. This process is crucial for the growth and spread of solid tumors, particularly once the tumor volume exceeds 2 mm, as the newly formed vascular network provides essential oxygen, nutrients, and growth factors to the tumor. Anti-angiogenesis therapy has become one of the commonly used targeted treatments for cancer in clinical practice.

Association of obesity and metabolic syndrome with incident primary open angle glaucoma in the UK Biobank.

Background: We sought to investigate the association between obesity, metabolic syndrome, and metabolic health with incident primary open-angle glaucoma (POAG).

Methods: We included 103 249 UK Biobank participants without previously diagnosed glaucoma or glaucoma-related procedures at enrolment. The primary outcome was POAG identified from diagnostic coding via linked hospital inpatient and primary care data.

Effect of structure and interaction on physicochemical properties of new [Emim][BFX] complex anion ionic liquids studied by quantum chemistry.

Context: One of the key challenges in the industrial application of ionic liquids (ILs) is their extreme characteristics, such as viscosity, glass transition temperatures, and conductivity. Understanding the relationship between ILs structure and physicochemical property is a crucial aspect of the directed design of ILs with good properties, which is a prerequisite for their successful implementation in industrial processes. In this work, high-level quantum-chemical research with for four pairs ionic liquids, [Emim][X] and [Emim][BFX] (X = CHSO, EtSO, HSO, Tos), was performed, to analyze the stable structure, interionic interaction, and charge transfer and provide a new insight into the property variances at the molecular level.

Proteomic Insights into the Effects of Jianweixiaoshi Tablets on Functional Dyspepsia with Spleen Deficiency in Rats.

Background: Jianweixiaoshi tablets (JWXS) is widely used in traditional Chinese medicine for treating functional dyspepsia with spleen deficiency (SD-FD) in China. However, the molecular mechanisms underlying the therapeutic effects of JWXS remain incompletely understood.

Methods: Functional dyspepsia was induced in rats with spleen deficiency by iodoacetamide in combination with the modified multiple platform method.

Analysis of risk factors affecting the prognosis of angiosarcoma patients: a retrospective study.

This study aimed to identify prognostic factors influencing the survival of angiosarcoma patients and to explore the relationship between peripheral blood indicators and patient prognosis. A retrospective analysis was conducted on the clinical data collected from 105 angiosarcoma patients treated at China-Japan Union Hospital of Jilin University from January 2004 to April 2019, with an additional 50 patients included as external validation cohort. The median survival time for the study cohort was 1395 days, with 66.

Positional encoding-guided transformer-based multiple instance learning for histopathology whole slide images classification.

Background And Objectives: Whole slide image (WSI) classification is of great clinical significance in computer-aided pathological diagnosis. Due to the high cost of manual annotation, weakly supervised WSI classification methods have gained more attention. As the most representative, multiple instance learning (MIL) generally aggregates the predictions or features of the patches within a WSI to achieve the slide-level classification under the weak supervision of WSI labels.

Surgical treatment outcomes and risk factors for post-TB lung disease.

Objective: This study aims to investigate the effectiveness and safety of surgical treatment for post-TB lung disease (PTLD) and to analyse its risk factors.

Methods: Data were collected from 268 patients who underwent pulmonary resection for TB in Xi'an Chest Hospital, Xi'an, Shaanxi, China, between January 2014 and December 2023. The efficacy and safety of the three groups were compared, and the TB group was used as the control group to analyse the risk factors of PTLD.

Trends of genetic contributions on epigenetic clocks and related methylation sites with aging: A population-based adult twin study.

Several crucial acceleration periods exist during aging process. Epigenetic clocks, serving as indicators of aging, are influenced by genetic factors. Investigating how the genetic contributions on these clocks change with age may provide novel insights into the aging process.

The correlation between dental caries and dermatoglyphics: a systematic review and meta-analysis.

Here, we used a meta-analysis approach to systematically evaluate the correlation between dental caries and dermatoglyphics. To identify findings relating to the association between dental caries and dermatoglyphics, a methodical literature search was conducted in the PubMed, Embase, Cochrane Library, and Web of Science databases from inception to August 2023. Data analysis was performed using RevMan 5.

Discovery of Chalcone Derivatives as Bifunctional Molecules with Anti-SARS-CoV-2 and Anti-inflammatory Activities.

Danshensu extracted with traditional Chinese medicine has a wide range of bioactivities. Danshensu containing a catechol moiety has a moderate inhibitory effect on SARS-CoV-2 3CL (IC = 2.2 μM) by a reversible covalent interaction and exhibits good anti-inflammatory activity.

Preprocessed Monomer Interfacial Polymerization for Scalable Fabrication of High-Valent Cluster-Based Metal-Organic Framework Membranes.

Current research on emergent membrane materials with ordered and stable nanoporous structures often overlooks the vital facet of manufacturing scalability. We propose the preprocessed monomer interfacial polymerization (PMIP) strategy for the scalable fabrication of high-valent cluster-based metal-organic framework (MOF) membranes with robust structures. Using a roll-to-roll device on commercial polymer supports, Zr-fum-MOF membranes are continuously processed at room temperature through the PMIP approach.

Jammed Pickering Emulsion Gels.

Emulsion gels with specific rheological properties have widespread applications in foods, cosmetics, and biomedicines. However, the constructions of water-in-oil emulsion gels are still challenging, due to the limited interactions available in the continuous oil phase. Here, a versatile strategy is developed to prepare a new type of emulsion gels, called Jammed Pickering emulsion gels (JPEGs).

Unveiling reflectance spectral characteristics of floating plastics across varying coverages: insights and retrieval model.

Marine floating debris, particularly chemically stable plastics, poses a significant global environmental concern. These materials, due to their prevalence and durability, linger on the ocean surface for extended durations, inflicting considerable harm on marine ecosystems, life, and the food chain. The traditional methodology for investigating marine floating debris mainly uses field observations, which are time-consuming, laborious, and constrained in observational scope.

Impact of preoperative risk factors on 5-year survival after fenestrated/branched endovascular aortic repair.

Objective: To investigate which preoperative factors most impact the 5-year survival of patients undergoing fenestrated/branched endovascular aortic repair (F/BEVAR) and to identify modifiable elements that, if time allows, should be actively managed and adequately controlled preoperatively.

Methods: Patients treated for aortic aneurysms with complex anatomy using either patient-specific company-manufactured or off-the-shelf F/BEVAR devices were included. The exposure of interest was aneurysm type (group I: type I-III thoracoabdominal aneurysms vs group II: type IV thoracoabdominal aneurysms vs group III: juxtarenal or suprarenal aneurysms), and the primary outcome was 5-year risk of all-cause mortality.

Case report: The first known case of male retroperitoneal mesonephric-like adenocarcinoma.

Aim: We aimed to analyze the clinico-pathological and molecular features of mesonephric-like adenocarcinoma (MLA) to enhance understanding of this tumor type.

Methods: This is the first case of MLA occurring in the retroperitoneum of a male patient. Clinico-pathological and molecular characteristics were analyzed, and the relevant literature was reviewed.

Effect of Epstein-Barr virus on macrophage M2/M1 migration and EphA2 expression in adverse drug reactions.

This study aims to investigate the effect of Epstein-Barr virus (EBV) reactivation or EBV reactivation with dexamethasone (DXM) in patients with adverse drug reactions (ADRs) through evaluating the levels of monocyte, macrophage M2/M1, and cytokines, and investigating whether expression of EBV receptor EphA2 could specifically influence EBV activation in ADRs. We performed a prospective longitudinal study to analyze the monocytes, macrophages, M2/M1 ratio, and cytokines, including interleukin (IL)-4, IL-13, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, IFN-β, C-X-C motif chemokine ligand (CXCL)9, and CXCL10, in patients with maculopapular exanthema (MPE) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), and control groups after disease onset. Skin biopsy samples from these patients were subjected to hematoxylin and eosin (H&E) staining to examine tissue architecture and inflammatory cell infiltration, as well as Epstein-Barr virus-encoded RNA (EBER) staining to detect the presence of EBV within the skin lesions.

Exploring the spatiotemporal effects of meteorological factors on hand, foot and mouth disease: a multiscale geographically and temporally weighted regression study.

The influence of meteorological factors on hand, foot, and mouth disease (HFMD) is not on the same scale, it's rare for previous studies to measure and recognize the independent regression relationship between each variable in space and time scale. This study used a multiscale geographically and temporally weighted regression (MGTWR) model to explore the relationship between the incidence of HFMD and related meteorological factors in Shandong Province, China, during 2015-2019 and attempted to quantify the influence of meteorological factors on HFMD under different spatiotemporal effects. Meanwhile, we used the Global Moran's I statistic and Local Moran's I statistic to test the spatial autocorrelation of the incidence of HFMD.

Gastric Cancer Risk among Immigrants and Socioeconomic Groups in the Netherlands.

Background: Identification of groups at a high risk of gastric cancer could facilitate targeted screening in countries with a low gastric cancer incidence. Our aim was to identify such high-risk groups based on individual-level population data on migration history and socioeconomic status (SES) in the Netherlands.

Methods: In this retrospective cohort study, patient data from the Netherlands Cancer Registry were linked to demographic data of Statistics Netherlands in the period 2010 to 2022.

Evaluating the performance and clinical decision-making impact of ChatGPT-4 in reproductive medicine.

Background: ChatGPT, a sophisticated language model developed by OpenAI, has the potential to offer professional and patient-friendly support. We aimed to assess the accuracy and reproducibility of ChatGPT-4 in answering questions related to knowledge, management, and support within the field of reproductive medicine.

Methods: ChatGPT-4 was used to respond to queries sourced from a domestic attending physician examination database, as well as to address both local and international treatment guidelines within the field of reproductive medicine.