Exercise Training in Adults With Congenital Heart Disease: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Background: Evidence from many studies demonstrates that regular exercise has a favorable effect on cardiovascular disease, but it is still unclear whether adults with congenital heart disease (ACHD) benefit from exercise training. The aim of this study was to assess the effects of exercise training on ACHD.

Methods: PubMed, EMBASE, the Cochrane Library, Cumulative Index to Nursing and Allied Health, and Web of Science databases were searched.

Target Elimination-Denatured and Unstable Proteins, Environmental Toxins, Metabolic Wastes, Immunosuppressive Factors and Chronic Inflammatory Factors of Medical System for Chronic Diseases Prevention and Health Promotion: A Narrative Review.

Background: The incidence of chronic diseases, such as cardiovascular disease, diabetes, overweight, obesity, cancer and other diseases has been increasing. It is a huge challenge to public health industry about how to provide risk intervention and preventive medical services and explore advanced technology platform for effective prevention and control of chronic diseases.

Methods: We collaborated domestic and international experts on preventive medicine, and analyzed pathogenesis and risk factors for the major chronic diseases.

Increased Risk of Second Primary Cancers Following Diagnosis of Malignant Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Population-Based Study.

Several studies have reported that intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are associated with extra-pancreatic malignancies. However, there have been no population-based studies evaluating the risk of second primary cancers (SPCs) in patients with pancreatic IPMN. The Surveillance, Epidemiology, and End Results (SEER) database was used to identify and characterize data from patients with IPMN of the pancreas.

Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO.

Liangyi Gao (LYG), a traditional Chinese medicine, is composed of Ginseng and Radix Rehmanniae Preparata, both of which have been shown to have antiaging properties. In Eastern countries, LYG is used to delay functional declines related to aging and has an obvious antiaging effect in clinical practice. However, little data from evidence-based medicine is available regarding whether LYG is beneficial overall, particularly with respect to lifespan, and how LYG functions.

Organic-Inorganic Hybrid Heterometallic Halides with Low-Dimensional Structures and Red Photoluminescence Emissions.

In recent years, although low-dimensional hybrid lead halides have received great attention due to the fascinating photoluminescent (PL) properties, the research is still on the early stage and only limited phases have been explored and characterized. Here, by introducing heterometals as mixed structural compositions and optical activity centers, we prepared a series of low-dimensional hybrid heterometallic halides, namely as, [(Me)-DABCO]CuPbI, [(Me)-DABCO]MPbI (M = Cu and Ag) and [(Me)-DABCO]AgPbBr (Me = methyl group, DABCO = 1,4-diazabicyclo[2.2.

Discovery and characterization of the evolution, variation and functions of diversity-generating retroelements using thousands of genomes and metagenomes.

Background: Diversity-generating retroelements (DGRs) are a unique family of retroelements that generate sequence diversity of DNA to benefit their hosts by introducing variations and accelerating the evolution of target proteins. They exist widely in bacteria, archaea, phage and plasmid. However, our understanding about DGRs in natural environments was still very limited.

Regulating the Basicity of Metal-Oxido Complexes with a Single Hydrogen Bond and Its Effect on C-H Bond Cleavage.

The functionalization of C-H bonds is an essential reaction in biology and chemistry. Metalloenzymes that often exhibit this type of reactivity contain metal-oxido intermediates that are directly involved in the initial cleavage of the C-H bonds. Regulation of the cleavage process is achieved, in part, by hydrogen bonds that are proximal to the metal-oxido units, yet our understanding of their exact role(s) is still emerging.

Enhanced Hydrogen Evolution Reaction Performance of NiCoP by Filling Oxygen Vacancies by Phosphorus in Thin-Coating CeO.

A series of NiCoP-based electrocatalysts, which were wrapped by CeO whose oxygen vacancies (V) are partially filled with phosphorus atoms (named as NiCoP/PFVo-CeO, where refers to the consumption of NaHPO·HO), have been fabricated to improve the electrocatalytic reactivity of NiCoP toward hydrogen evolution in alkaline solution. In the novel catalysts, the P atoms fill the oxygen vacancies, elevate the chemical valence state of Ni and Co, and increase the hydride acceptors, which reinforcing the promoting effect of CeO in the hydrogen evolution reaction (HER). Moreover, the negatively charged P atoms capture the positively charged protons more easily, benefiting the Volmer step during HER.

Facile Preparation of Cucurbit[6]uril-Based Polymer Nanocapsules for Targeted Photodynamic Therapy.

Covalently self-assembled polymer nanocapsules (NCs) based on cucurbit[6]uril have been previously prepared and their applications in payload delivery and bioimaging have been demonstrated, showing significant potentials. However, the preparation of these NCs often requires laborious and tedious multistep reactions, including a low-yield conversion of perhydroxycucurbit[6]uril to perallyloxycucurbit[6]uril, subsequent photopolymerization of perallyloxycucurbit[6]uril with dithiol linkers, and two additional steps of treatment to remove disulfide loops and create cationic sulfoniums. Herein, we report a novel, facile approach leading to cucurbit[6]uril-based polymer NCs via direct alkylation of perhydroxycucurbit[6]uril with a ditopic linker, thereby saving significant time and efforts, which may lead to significant expansion in investigations of these unique materials in various applications, particularly biomedical sciences.

Hierarchical Uniform Supramolecular Conjugated Spherulites with Suppression of Defect Emission.

Easily processed, well-defined, and hierarchical uniform artificial architectures with intrinsic strong crystalline emission properties are necessary for a range of light-emitting optoelectronic devices. Herein, we designed and prepared ordered supramolecular spherulites, comprising planar conformational molecules as primary structures and multiple hydrogen bonds as physical cross-links. Compared with serious aggregation-induced fluorescence quenching (up to 70%), these highly ordered architectures exhibited unique and robust crystalline emission with a high PLQY of 55%, which was much higher than those of other terfluorenes.

A model for comprehensive oral biological age score with oral and systemic clinical parameters.

Background: Biological age reflects the functional status of an individual. The purpose of the study was to develop a model for estimating oral biological age with oral and systemic parameters.

Methods: A total of 248 subjects who had a routine health check were assessed with oral and general clinical examination.

To distinguish the primary characteristics of agro-waste biomass by the principal component analysis: An investigation in East China.

The different physicochemical properties of various agro-waste biomasses require a diversity of bioenergy utilization patterns. This study investigated the characteristics of a total of 74 manures and 78 crop straw samples from East China to identify the primary characteristic indicators that are essential to distinguish specific agro-wastes from others. Principal component analysis was applied, to discover critical features of biomass for the decision-making regarding the bioenergy production mode.

Physical Layer Key Generation in 5G and Beyond Wireless Communications: Challenges and Opportunities.

The fifth generation (5G) and beyond wireless communications will transform many exciting applications and trigger massive data connections with private, confidential, and sensitive information. The security of wireless communications is conventionally established by cryptographic schemes and protocols in which the secret key distribution is one of the essential primitives. However, traditional cryptography-based key distribution protocols might be challenged in the 5G and beyond communications because of special features such as device-to-device and heterogeneous communications, and ultra-low latency requirements.

pH-sensitive loaded retinal/indocyanine green micelles as an "all-in-one" theranostic agent for multi-modal imaging in vivo guided cellular senescence-photothermal synergistic therapy.

In this study, pH-sensitive loaded retinal/indocyanine green (ICG) micelles were developed to realize novel approaches for cellular senescence-photothermal synergistic therapy to treat cancer. The micelles could enable effective multi-modal imaging in vivo guided therapy and show anticancer activity in vitro and in vivo with satisfactory biosafety.

A Highly Efficient Red Metal-free Organic Phosphor for Time-Resolved Luminescence Imaging and Photodynamic Therapy.

Developing highly efficient red metal-free organic phosphors for biological applications is a formidable challenge. Here, we report a novel molecular design principle to obtain red metal-free organic phosphors with long emission lifetime (504.6 μs) and high phosphorescence efficiency (14.

Functional characterization of an orexin neuropeptide in amphioxus reveals an ancient origin of orexin/orexin receptor system in chordate.

Amphioxus belongs to the subphylum cephalochordata, an extant representative of the most basal chordates, whose regulation of endocrine system remains ambiguous. Here we clearly demonstrated the existence of a functional orexin neuropeptide in amphioxus, which is able to interact with orexin receptor, activate both PKC and PKA pathways, decrease leptin expression, and stimulate lipogenesis. We also showed the transcription level of amphioxus orexin was affected by fasting or temperature, indicating a role of this gene in the regulation of energy balance.

Sub-3 Å apoferritin structure determined with full range of phase shifts using a single position of volta phase plate.

Volta Phase Plate (VPP) has become an invaluable tool for cryo-EM structural determination of small protein complexes by increasing image contrast. Currently, the standard protocol of VPP usage periodically changes the VPP position to a fresh spot during data collection. Such a protocol was to target the phase shifts to a relatively narrow range (around 90°) based on the observations of increased phase shifts and image blur associated with more images taken with a single VPP position.

Risk and clinicopathological features of osteosarcoma metastasis to the lung: A population-based study.

Background: Osteosarcoma is the most common primary sarcoma of the bone. Lung osteosarcoma metastases at diagnosis have a significantly poor prognosis, even when surgery plus chemotherapy are performed. Our goal was to analyze clinical and sarcoma characteristics that could help identify factors related to an increased rate of lung metastasis and to identify different modes of treatment and its correlation with survival.

A novel braided biodegradable stent for use in congenital heart disease: Short-term results in porcine iliac artery.

To evaluate the properties and efficacy of a novel braided biodegradable stent (BBS) consisting of poly (p-dioxanone) (PPDO) and polycaprolactone (PCL) for usage in children with congenital cardiovascular diseases. PCL/PPDO composite filaments were fabricated by coating PCL layers onto PPDO filaments, which were fused with PPDO monofilaments to form the BBS. Physical properties of BBSs including elastic recovery rate, deformation rate, and mechanical characteristics with adjunctive post-dilation were evaluated by radial force-tests.

Emission characteristics for co-combustion of leather wastes, sewage sludge, and coal in a laboratory-scale entrained flow tube furnace.

Four different mixed fuels consisted of leather waste, coal, and sewage sludge were combusted in a lab-scale entrained flow fluidized bed furnace. The influence of blending ratio on emission characteristics of SO, NO, HCl, particulate matter (PM), heavy metals, and polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) was studied. Results showed that the mixing of coal with sewage sludge had a complex effect on the emission characteristics.

Enhanced adsorption for Pb(II) and Cd(II) of magnetic rice husk biochar by KMnO modification.

Novel KMnO-treated magnetic biochar (FMBC) was successfully synthesized by addition of Fe(NO) during carbonization and KMnO treatment following for Pb(II) and Cd(II) adsorption. SEM-EDS, XPS, and ICP-AES were used to evaluate the FMBC and magnetic biochar (FBC) on surface morphology, surface chemistry characteristics, surface functional groups, and Pb(II) and Cd(II) adsorption behavior. Results showed that the Langmuir maximum adsorption quantity of FMBC reached 148 mg/g for Pb(II) and 79 mg/g for Cd(II), nearly 7 times of that of FBC.

Effects of ZnO nanoparticles on the toxicity of cadmium to duckweed Lemna minor.

Release of nanoparticles into the aquatic environment will inevitably influence the behavior and toxicities of other existing pollutants. In the present study, 10 mg/L of nano-ZnO (diameter 20-30 nm) was used to evaluate its impacts on cadmium (Cd) toxicity on duckweed Lemna minor based on IC values and four biological parameters including percent inhibition of growth rate (I), ratio of chlorophyll/pheophytin (D665/D665a), antioxidant enzymes, and H-ATPase. Results of the 96-h IC values of Cd with or without nano-ZnO indicate no additional toxicological effects of nano-ZnO to plants.

MicroRNA-128 confers protection against cardiac microvascular endothelial cell injury in coronary heart disease via negative regulation of IRS1.

Objective: Cardiac microvascular endothelial cells (CMECs) play a critical role in the physiological regulation of coronary blood flow and its dysfunction is associated with myocardium ischemic injury. This study was performed to clarify the effect of microRNA-128 (miR-128) on the CMEC injury in coronary heart disease (CHD) by binding to insulin receptor substrate 1 (IRS1).

Methods: The rat CMECs were cultured by explant culture method and identified by CD31 immunofluorescence assay.

Antiplatelet aggregation and antithrombotic benefits of terpenes and flavones from hawthorn leaf extract isolated using the activity-guided method.

Hawthorn is a well-known functional food; at present, increasing attention has been given to hawthorn leaf due to its numerous functional and nutritional properties. In this study, the antithrombotic properties of hawthorn leaves were evaluated using the activity-guided isolation process and high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-QTOF-MS). A crude extract prepared in 75% ethanol was fractionated using macroporous resin D101 and polyamide chromatography to obtain three active fractions (Fr.

Highly Efficient Ultralong Organic Phosphorescence through Intramolecular-Space Heavy-Atom Effect.

Metal-free organic phosphorescent materials have attracted considerable attention in the fields of organic electronics and bioelectronics. However, it remains a great challenge to achieve organic phosphors with high quantum efficiency in a single-component system. We designed and synthesized two organic phosphors (PDCz and PDBCz) with an ultralong organic phosphorescence (UOP) feature.