ROS-ATM-CHK2 axis stabilizes HIF-1α and promotes tumor angiogenesis in hypoxic microenvironment.

Hypoxia is an established hallmark of tumorigenesis. HIF-1α activation may be the prime driver of adaptive regulation of tumor cells reacting to hypoxic conditions of the tumor microenvironment. Here, we report a novel regulatory mechanism in charge of the fundamental stability of HIF-1α in solid tumor.

Effects of engineering injection and supplement mode of in-situ biogeochemical transformation enhancement EVO-FeSO on the remediation of tetrachloroethylene contaminated aquifer.

Traditional in situ biogeochemical transformation suffers from competition among crucial microorganisms and inadequate formation of reactive minerals, thus leading to the accumulation of toxic intermediates. In this study, three regulation schemes were proposed to solve these problems from the perspective of engineering mode. Results showed intermittent injection mode effectively reduced the accumulation of toxic intermediates but the reduction rate of tetrachloroethylene was decreased.

Boosting Thermoelectric Performance of Wet-Spun PEDOT:PSS-Based Organic/Inorganic Composite Fibers via a Dual-Interfacial Engineering Approach.

Organic/inorganic thermoelectric (TE) composite fibers are promising for wearable electronics due to their flexibility and energy conversion capabilities, yet their performance remains limited. Here, we have successfully developed novel dual-interfacial structured poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate)/single-walled carbon nanotube@ polyaniline (PEDOT:PSS/SWCNT@PANI) TE composite fibers via wet-spinning PANI was introduced between SWCNTs and PEDOT:PSS as an interlayer, which not only improved the dispersibility of SWCNTs in aqueous PEDOT:PSS but also facilitated the formation of numerous highly uniform dual-interfaces at PEDOT:PSS/PANI and PANI/SWCNT contacts.Therefore, the PEDOT:PSS/SWCNT@PANI composite fibers exhibited a high degree of structural alignment and more efficient energy filtering effect.

Personalizing Vision-Language Models With Hybrid Prompts for Zero-Shot Anomaly Detection.

Zero-shot anomaly detection (ZSAD) aims to develop a foundational model capable of detecting anomalies across arbitrary categories without relying on reference images. However, since "abnormality" is inherently defined in relation to "normality" within specific categories, detecting anomalies without reference images describing the corresponding normal context remains a significant challenge. As an alternative to reference images, this study explores the use of widely available product standards to characterize normal contexts and potential abnormal states.

Management of an asymptomatic pulmonary arteriovenous fistula diagnosed prenatally by detachable balloon embolization: a case report.

Background: Pulmonary arteriovenous fistulas (PAVFs) are abnormal vascular malformations that connect pulmonary arteries and pulmonary veins, resulting in a right-to-left shunt. This anatomical shunt leads to a decrease in arterial oxygen saturation. Patients with PAVFs are usually treated with embolization or surgical procedures.

Alcohol dehydrogenase iron containing 1 () is associated with liver metastasis and regulates cellular function of gastric cancer.

BackgroundLiver metastasis and chemotherapy resistance are two unfavorable factors for the outcomes of gastric cancer patients. was identified as cancer-related molecule and candidate for early detection in gastric cancer. This study evaluated the significance of in gastric cancer, aiming to explore a potential biomarker and therapeutic target for gastric cancer.

Optimizing Nitrate Electroreduction toward Nearly 100% Ammonia Selectivity through Synergistic RuCu Catalysts and Integrated Coupled Anodic Reaction for High-Value Products.

Copper-based catalysts have been widely used in the field of the nitrate reduction reaction (NORR) to ammonia, demonstrating high nitrate reduction rates. However, their low selectivity for ammonia production poses significant limitations in practical applications. In this study, we present that the incorporation of Ru into the Cu@Ni foam can achieve nearly 100% selectivity for NH and a high faradaic efficiency of 96.

Analysis of cervical bone mineral density in children and adolescents using cone beam computed tomography combined with liquid phantoms.

To describe cervical bone mineral density (BMD) in children and adolescents using Cone-beam Computed Tomography (CBCT) combined with K2HPO4 liquid phantoms. Children and adolescents aged 7-19 years who underwent CBCT for orthodontic treatment in our imaging department between January 2023 and June 2023 were selected. The CT values of the second (C2) and third (C3) cervical vertebrae were measured using the software supplied with the CBCT.

Cuprous-Sulfide-Nanoplate-Catalyzed Click Chemistry for In Situ Construction of Covalent Organic Polymer Heterostructures for Efficient Photocatalytic Reduction and Removal of U(VI).

In this study, a core-shell heterostructure of cuprous sulfide (CuS) nanoplates and covalent organic polymers (COPs) (CuS@COP) was constructed in situ by a CuS-catalyzed azide-alkyne reaction for efficient reduction and rapid removal of U(VI) from uranium mine wastewater. The simple in situ synthesis of heterojunctions through click chemistry reactions can create a tight bond at the interface and evade the laborious process of conventional composites. The different Fermi energy levels of CuS and COP induce the formation of a built-in electric field within the core-shell heterojunction, and the photogenerated charge transfer from the COP to CuS nanoplate results in a substantial boost in the efficiency of the photocatalytic reduction of U(VI).

A Peculiar Tracheoesophageal Fistula Caused by a Plastic Foreign Body.

The occurrence of tracheoesophageal fistula (TEF) in children is commonly attributed to the presence of foreign bodies. This paper presents a unique case admitted to the Children's Hospital of Nanjing Medical University on August 9, 2022, where a plastic fragment resembling a doll's eye was identified as the precipitating factor. The report investigates the unusual trajectory of this case-examining the pathway through which the foreign body became lodged in the trachea, followed by the subsequent development of TEF-and provides valuable insights into its pathogenesis and clinical significance.

Study on the Mechanisms of Ischemic Stroke Impacting Sleep Homeostasis and Circadian Rhythms in Rats.

Objective: This study aimed to investigate the impact of ischemic stroke (IS) on sleep homeostasis and circadian rhythms in rats, as well as the underlying mechanisms.

Methods: The middle cerebral artery occlusion model was employed to induce IS in rats. Sixty young and sixty aged rats were randomly divided into six groups for experiments.

Vitexin alleviates lipid metabolism disorders and hepatic injury in obese mice through the PI3K/AKT/mTOR/SREBP-1c pathway.

Obesity is recognized as a metabolic disorder, and its treatment and management pose ongoing challenges worldwide. Hawthorn, a traditional Chinese herb used to alleviate digestive issues and reduce blood lipid levels, has unclear mechanisms of action regarding its active components in the treatment of obesity. This study investigated the anti-obesity effects of vitexin, a major flavonoid compound found in hawthorn, in high-fat diet (HFD)-induced C57BL/6 mice.

Multifunctional Carbon Foam with Nanoscale Chiral Magnetic Heterostructures for Broadband Microwave Absorption in Low Frequency.

The construction of carbon nanocoil (CNC)-based chiral-dielectric-magnetic trinity composites is considered as a promising approach to achieve excellent low-frequency microwave absorption. However, it is still challenging to further enhance the low frequency microwave absorption and elucidate the related loss mechanisms. Herein, the chiral CNCs are first synthesized on a three-dimensional (3D) carbon foam and then combined with the FeNi/NiFeO nanoparticles to form a novel chiral-dielectric-magnetic trinity foam.

Computational Tools for Studying Genome Structural Variation.

Structural variation (SV) typically refers to alterations in DNA fragments at least 50 base pairs long in the human genome. It can alter thousands of DNA nucleotides and thus significantly influence human health, disease, and clinical phenotypes. There is a shared and growing recognition that the emergence of effective computational tools and high-throughput technologies such as short-read sequencing and long-read sequencing offers novel insight into SV and, by extension, diseases affecting planetary health.

Serum mature microRNA panel: A novel approach for primary prostate cancer diagnosis.

Background: Prostate cancer (PC) is the second most common malignant tumor in males and a leading cause of cancer-related morbidity and mortality among men. Early detection is essential for improving outcomes. Although prostate-specific antigen (PSA) is widely used for PC screening, it suffers from high false positive and false negative rates.

A transcription factor SlWRKY71 activated the HS generating enzyme SlDCD1 enhancing the response to Pseudomonas syringae pv DC3000 in tomato leaves.

HS is a well-known gaseous signaling molecule that plays important roles in plant response to biotic stresses. Pseudomonas syringae pv tomato (Pst) could cause enormous loss, while whether HS could modulate plant defense against Pst is still unclear. By CRISPR/Cas9, the Sldcd1 gene editing mutant showed reduced endogenous HS content and attenuated resistance, whereas treatment with exogenous HS could enhance the resistance.

Preparation and evaluation of T4SS recombinant proteins in serodiagnosis of human brucellosis based on TMT-based proteomics technology.

Introduction: Brucellosis, a significant zoonotic infectious disease, poses a global health threat. Accurate and efficient diagnosis is crucial for prevention, control, and treatment of brucellosis. VirB proteins, components of the Type IV secretion system (T4SS) in , play a pivotal role in bacterial virulence and pathogenesis but have been understudied for their diagnostic potential.

Immunological characterization and prognostic of colon cancer evaluated by angiogenesis-related features: a computational analysis and in vitro experiments.

Background: Diseases are often caused by multiple factors, angiogenesis-related genes (ARGs) have been shown to be associated with cancer, however, their role in colon cancer had not been fully explored. This study investigated potential biomarkers based on ARGs to improve prognosis and treatment effect in colon cancer.

Methods: ARGs associated with colon cancer prognosis were identified using Cox regression analysis and LASSO analysis.

Global, regional, national burden of asthma from 1990 to 2021, with projections of incidence to 2050: a systematic analysis of the global burden of disease study 2021.

Background: Asthma is the second leading cause of mortality among chronic respiratory illnesses. This study provided a comprehensive analysis of the burden of asthma.

Methods: Data on asthma were extracted from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021.

Morphological Characteristics of Inferior Pole Patellar Fractures and a Finite-Element Analysis Combined With a Retrospective Clinical Study of Anchor Suture and Titanium Cable Cerclage Treatment.

Objective: Inferior pole patellar fractures (IPPFs) pose a significant challenge due to their complex fracture patterns and high risk of complications associated with current treatment methods. This study aims to (1) characterize the fracture patterns of IPPFs using fracture mapping and (2) compare the biomechanical stability and clinical outcomes of treatment with anchor suture with patellar cerclage versus Kirschner-wire tension band combined with patellar cerclage.

Methods: (1) A retrospective analysis was conducted on 61 patients with IPPF.

PLGA confers upon conventional nonfluorescent molecules luminescent properties to trigger O-induced pyroptosis and immune response in tumors.

Pyroptosis, a recently identified cellular demise regulated by gasdermin family proteins, is emerging as a promising avenue in cancer immunotherapy. However, the realm of light-controlled pyroptosis in cancer cells remains largely unexplored. In this study, we took a deliberate approach devoid of any chemical alterations to develop a novel photosensitizer called "pharmaceutical-dots (pharm-dots)" by combining nonemissive polymers (Poly (lactic-co-glycolic acid), PLGA) with nonfluorescent invisible molecules like curcumin, berberine, oridonin into PLGA nanoparticles (PLGA-NPs).

Ferroelectric capacitive memories: devices, arrays, and applications.

Ferroelectric capacitive memories (FCMs) utilize ferroelectric polarization to modulate device capacitance for data storage, providing a new technological pathway to achieve two-terminal non-destructive-read ferroelectric memory. In contrast to the conventional resistive memories, the unique capacitive operation mechanism of FCMs transfers the memory reading and in-memory computing to charge domain, offering ultra-high energy efficiency, better compatibility to large-scale array, and negligible read disturbance. In recent years, extensive research has been conducted on FCMs.

L-Aspartic Acid with Dual Functions: An Eco-Friendly and Affordable Choice to Accelerate High Salinity Brine Utilization.

L-Aspartic acid (L-Asp) poses a dual function, which can affect the evaporation and crystallization process of the high-salinity brine by altering the physical or chemical properties of the salts. MSWI (municipal solid waste incineration) fly ash washing leachate, as a typical high-salinity brine, is utilized here to validate this hypothesis under the simulation guidance. Since L-Asp has stronger adsorption energy on the (110) crystal face of CaCO, L-Asp can facilitate the preferential growth of more valuable vaterite during the softening process (pretreatment before crystallization).

Rapid electrothermal upcycling hexachlorobutadiene (HCBD) polluted distillation residue into turbostratic graphene for enhanced electromagnetic wave absorption.

The trichloroethylene production industry generates high-boiling-point solid residues during rectification, which contain high concentrations of chlorinated contaminants, particularly hexachlorobutadiene (HCBD). Traditionally, these distillation residues are managed through co-incineration or landfilling, leading to environmental and economic challenges. In this study, we present a rapid and environmentally friendly electrothermal approach for both detoxifying and upcycling distillation residue into graphene-based electromagnetic wave (EMW) absorbing materials.