A case report of S1-S3 sacroiliac screw fixation for posterior pelvic ring injury with S1 sacral dysmorphism.

Introduction: There are few reports on the treatment of pelvic posterior ring injury with Sacral 1 - Sacral 3(S1-S3)sacroiliac screw fixation. This article reports a case of pelvic posterior ring injury with S1 sacral dysmorphism treated with S1-S3 sacroiliac screw fixation and reviews the relevant research progress.

Presentation Of The Case: A 72-year-old man riding e-bike was struck by a car at a high speed and diagnosed with pelvic fracture.

Toxicity of rare earth elements europium and samarium on zebrafish development and locomotor performance.

Rare earth elements are integral to modern technology, but their increasing environmental distribution due to anthropogenic activities poses potential health risks to humans. This study utilized zebrafish as a model to assess developmental and locomotor performance effects of europium and samarium. Exposure to Eu or Sm induced a reduction in heart rate, growth inhibition, and morphological deformities.

Dapagliflozin attenuates skeletal muscle atrophy in diabetic nephropathy mice through suppressing Gasdermin D-mediated pyroptosis.

Background: Skeletal muscle atrophy is a clinical concern in diabetic nephropathy, and without effective therapeutic approaches. Massive evidence has demonstrated that dapagliflozin, a sodium-glucose co-transporter 2 inhibitor can relieve diabetic nephropathy by inhibiting glucose re-absorption or podocyte pyroptosis. Nevertheless, whether dapagliflozin could treat skeletal muscle atrophy or the potential protection mechanism in diabetic nephropathy mice is unclear.

Targeting p38 MAPK signaling pathway and neutrophil extracellular traps: An important anti-inflammatory mechanism of Huangqin Qingre Chubi Capsule in rheumatoid arthritis.

Rheumatoid arthritis (RA) is a common chronic autoimmune disease. Neutrophils release and their extracellular traps (NETs) tend to result in synovial inflammation and cartilage damage. Huangqin Qingre Chubi Capsule (HQC) is an important herbal formulation for RA treatment and has been used for many years.

Association between adults' vaccine literacy and their intention to recommend older family members for influenza vaccine.

Objective: Seasonal influenza vaccine is effective to reduce the risk of hospitalization and death in vulnerable older persons, but the coverage of influenza vaccine remains low in these population in China. This study thus aimed to investigate how adults' vaccine literacy affects their intention to recommend influenza vaccination to older family members in China.

Methods: A cross-sectional survey was performed in China during October 7 to 16, 2023 through a web-based questionnaire.

Characterization of flavor profiles of water-boiled pork meatballs at different ultrasonic powers using solid-phase microextraction gas chromatography-mass spectrometry combined with electronic nose.

The objective of this study was to evaluate the flavor profiles of water-boiled pork meatballs at different ultrasonic powers (0, 150, 300, 450, 600, and 750 W) using solid-phase microextraction gas chromatography-mass spectrometry (SPME-GC-MS) combined with electronic nose (E-nose). A total of 36 volatile compounds were determined by SPME-GC-MS, including alcohols, aromatic hydrocarbons, aldehydes, terpenes, alkanes, phenols, ketones, and other. With the appropriate ultrasound treatment, the type and relative content of volatile compounds were significantly increased (P < 0.

A Novel Custom Bent 27-Gauge Needle-Guided Suture Snare Technique for Scleral Fixation of Posterior Chamber Intraocular Lenses.

Purpose: To describe a custom bent 27-gauge needle-guided suture snare technique for scleral fixation of posterior chamber intraocular lenses (PCIOL).

Methods: An 8-0 polypropylene suture was threaded into the lumen of a custom bent 27-gauge needle, and the needle tip was advanced into the eye from the intraocular lens (IOL) fixation point. The suture was threaded through the posterior limbal incision inside the IOL haptic loop and pulled out.

L-Aspartic Acid with Dual Functions: An Eco-Friendly and Affordable Choice to Accelerate High Salinity Brine Utilization.

L-Aspartic acid (L-Asp) poses a dual function, which can affect the evaporation and crystallization process of the high-salinity brine by altering the physical or chemical properties of the salts. MSWI (municipal solid waste incineration) fly ash washing leachate, as a typical high-salinity brine, is utilized here to validate this hypothesis under the simulation guidance. Since L-Asp has stronger adsorption energy on the (110) crystal face of CaCO, L-Asp can facilitate the preferential growth of more valuable vaterite during the softening process (pretreatment before crystallization).

A case series of ultrasound and pathological assessment of follicular thyroid tumors: Addressing indeterminate malignancy.

Rationale: Follicular tumors with uncertain malignant potential of the thyroid are a new classification of thyroid tumors in the World Health Organization (2017). Only a few cases of evaluating the value of ultrasound combined with pathological examination in diagnosing follicular tumors with uncertain malignant potential of the thyroid have been reported in recent decades.

Patient Concerns: A retrospective analysis was performed on 18 patients with follicular tumors with uncertain thyroid malignant potential who underwent preoperative ultrasonography and were confirmed by operation and pathology in our hospital from January 2019 to November 2024.

Spin Magnetic Effect Activate Dual Site Intramolecular O─O Bridging for Nickel-Iron Hydroxide Enhanced Oxygen Evolution Catalysis.

The oxygen evolution reaction (OER) involves the recombination of diamagnetic hydroxyl (OH) or water (HO) into the paramagnetic triplet state of oxygen (O). The spin conservation of oxygen intermediates plays a crucial role in OER, however, research on spin dynamics during the catalytic process remains in its early stages. Herein, β-Ni(OH) and Fe-doped β-Ni(OH) (NiFe(OH)) are utilized as model catalysts to understand the mechanism of spin magnetic effects at iron (III) sites during OER.

Continuous Core Body Temperature Monitoring for Heatstroke Alert via a Wearable In-Ear Thermometer.

Heatstroke, a global concern exacerbated by climate change, poses significant health risks, potentially leading to multiorgan damage and fatalities. Core body temperature (CBT) is a critical and precise indicator of heatstroke, and its continuous monitoring could serve as a pivotal tool for early detection. Traditional CBT measurements, often invasive (e.

Targeting TTK Inhibits Tumorigenesis of T-Cell Lymphoma Through Dephosphorylating p38α and Activating AMPK/mTOR Pathway.

T-cell lymphoma (TCL) is a group of non-Hodgkin's lymphoma with high heterogeneity and unfavorable prognosis. Current standard treatments have demonstrated limited efficacy in improving the outcomes for TCL patients. Therefore, identification of novel drug targets is urgently needed to improve the prognosis of TCL patients.

Treatment of Denervated Muscle Atrophy by Injectable Dual-Responsive Hydrogels Loaded with Extracellular Vesicles.

Denervated muscle atrophy, a common outcome of nerve injury, often results in irreversible fibrosis due to the limited effectiveness of current therapeutic interventions. While extracellular vesicles (EVs) offer promise for treating muscle atrophy, their therapeutic potential is hindered by challenges in delivery and bioactivity within the complex microenvironment of the injury site. To address this issue, an injectable hydrogel is developed that is responsive to both ultrasound and pH, with inherent anti-inflammatory and antioxidant properties, designed to improve the targeted delivery of stem cell-derived EVs.

Biomaterial Surface-Mediated Macrophages Exert Immunomodulatory Roles by Exosomal CCL2-Induced Membrane Integrin β1 Trafficking in Recipient Cells.

The interaction between biomaterials and immune system is a critical area of research, especially in tissue engineering and regenerative medicine. A fascinating and less explored aspect involves the immunomodulatory behaviors of macrophage (MΦ)-derived exosomes induced by biomaterial surfaces. Herein, untreated surface, nanostructured surface, and type I collagen (Col-I)-decorated nanostructured surface of titanium implants are chosen to culture MΦs, followed by extraction of MΦ-derived exosomes and investigation of their immunomodulatory functions and mechanisms.

Reaction Path-Resolved Quantum Transition State Framework Using Hyperspherical (APH) Coordinates: The Geometric Phase Effects in the H + H Reaction.

The quantum transition state framework was developed to calculate the reaction path-resolved scattering matrix for atom-diatom reactions in hyperspherical (APH) coordinates. This approach allows for simply and directly calculating the reaction path-resolved scattering matrix, especially when the encircling reaction path is negligible. It could be used to determine the reactivities of specific pathways in a chemical reaction, providing insights into phenomena such as geometric phase effects.

Non-canonical Wnt signaling pathway activated NFATC3 promotes GDF15 expression in MASH: prospective analyses of UK biobank proteomic data.

Background: Our previous research demonstrated that growth differentiation factor 15 (GDF15) exhibited superior predictive capability for metabolic dysfunction-associated steatohepatitis (MASH) development with an AUC of 0.86 at 10 years before disease diagnosis. However, the specific pathways and molecular mechanisms associated with GDF15 expression during MASH development remain to be fully investigated in humans.

Sexual spores in mushrooms: bioactive compounds, factors and molecular mechanisms of spore formation.

Throughout the life cycle of mushrooms, countless spores are released from the fruiting bodies. The spores have significant implications in the food and medicine industries due to pharmacological effects attributed to their bioactive ingredients. Moreover, high concentration of mushroom spores can induce extrinsic allergic reactions in mushroom cultivation workers.

Machine learning-based prognostic model for patients with anaplastic thyroid carcinoma.

Objective: Despite the identification of various prognostic factors for anaplastic thyroid carcinoma (ATC) patients over the years, a precise prognostic tool for these patients is still lacking. This study aimed to develop and validate a prognostic model for predicting survival outcomes for ATC patients using random survival forests (RSF), a machine learning algorithm.

Methods: A total of 1222 ATC patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database and randomly divided into a training set of 855 patients and a validation set of 367 patients.

The efficacy and safety of suvemcitug, envafolimab, and FOLFIRI in microsatellite-stable or mismatch repair-proficient colorectal cancer: preliminary results of a phase 2 study.

Purpose: This phase II study is designed to evaluate the combination therapy involving suvemcitug and envafolimab with FOLFIRI in microsatellite-stable or mismatch repair-proficient (MSS/pMMR) colorectal cancer (CRC) in the second-line treatment setting.

Methods: This study is a non-randomized, open-label prospective study comprising multiple cohorts (NCT05148195). Here, we only report the data from the CRC cohort.

Synergistic effect of canine FGF-21 combined with insulin in the treatment of canine diabetes.

Previous studies have shown that FGF-21 can ameliorate hyperglycemia and improve the level of oxidative stress in vivo in diabetic mice. The hypoglycemic effect is safe and lasting, but it takes a longer time to exert its effect. Insulin treatment of canine diabetes takes effect quickly; however, its action time is short, and it is prone to cause hypoglycemia.

Robust bifunctionality towards hydrogen evolution and ethanol oxidation reactions catalyzed by six-element high-entropy alloys.

FeCoNiIrPtPd/NCNT exhibits 3.4- and 1.6-fold higher levels of mass activity than does commercial Pt/C in the hydrogen evolution reaction (HER) and ethanol oxidation reaction (EOR), respectively.

Activation of APJ Receptors by CMF-019, But Not Apelin, Causes Endothelium-Dependent Relaxation of Spontaneously Hypertensive Rat Coronary Arteries.

Receptors for the vasoactive adipokine apelin, termed APJ receptors, are G-protein-coupled receptors and are widely expressed throughout the cardiovascular system. APJ receptors can also signal via G-protein-independent pathways, including G-protein-coupled-receptor kinase 2 (GRK2), which inhibits nitric oxide synthase (eNOS) activity and nitric oxide (NO) production in endothelial cells. Apelin causes endothelium-dependent, NO-mediated relaxation of coronary arteries from normotensive animals, but the effects of activating APJ receptor signaling pathways in hypertensive coronary arteries are largely unknown.

Study on a compact pulse forming line-Marx type high voltage pulse generator.

High power pulse generators are moving in the direction of compact, solid-state, and stable working in a relatively long time. In this paper, a compact pulse forming line-Marx type high power pulse generator, based on a ceramic pulse forming line and a spark gap switch with carbide modified graphite electrodes, is studied numerically and experimentally. Specifically, a ceramic based pulse forming line with high relative permittivity was used to achieve long pulse duration in a limited dimension.

Global urban greening and its implication for urban heat mitigation.

Urban vegetation provides essential ecosystem services and benefits to support biodiversity and human well-being in urban areas. However, the dynamic trends, driving factors, and their implications to urban heat mitigation at the global scale remain largely unclear. Here, we used a high-resolution enhanced vegetation index (EVI) dataset to examine the vegetation dynamics in 11,235 urban areas worldwide, identify the driving factors behind its changes, and estimate the potential urban heat mitigation benefits of these changes.

Stay hungry for morality: the inhibitory effect of high moral identity and moral elevation on moral licensing.

Moral licensing, a phenomenon where initial moral behavior can lead to later immoral behavior, challenges the sustainability of moral behavior over short-term periods. In the framework of moral self-regulation, current research examined the inhibitory effects of high moral identity and moral elevation on moral licensing. Across three studies we consistently found that recalling past moral behavior can trigger moral licensing (Study 1, 2, 3).