S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism.

Ferroptosis is a newly identified programmed cell death induced by iron-driven lipid peroxidation and implicated as a potential approach for tumor treatment. However, emerging evidence indicates that hepatocellular carcinoma (HCC) cells are generally resistant to ferroptosis and the underlying molecular mechanism is poorly understood. Here, our study confirms that S100 calcium binding protein P (S100P), which is significantly up-regulated in ferroptosis-resistant HCC cells, efficiently inhibits ferroptosis.

Nanoscale thickness Octave-spanning coherent supercontinuum light generation.

Coherent broadband light generation has attracted massive attention due to its numerous applications ranging from metrology, sensing, and imaging to communication. In general, spectral broadening is realized via third-order and higher-order nonlinear optical processes (e.g.

Understanding Awareness, Utilization, and the Awareness-Utilization Gap of HIV PrEP and nPEP Among Young MSM in China.

HIV/AIDS remains a significant public health challenge in China, particularly among men who have sex with men (MSM). Pre-Exposure Prophylaxis (PrEP) and non-occupational post-exposure Prophylaxis (nPEP) are effective interventions to reduce HIV transmission in high-risk populations. This study assessed awareness and utilization levels of PrEP and nPEP among young MSM (YMSM) aged 18-29 in China and examined associated factors.

Astemizole Exacerbates 5-Fluorouracil-Triggered Cardiotoxicity by Enhancing Ptgs2.

5-fluorouracil (5-FU), a commonly utilized antitumor agent for the treatment of colon cancer, is linked to an increased risk of cardiovascular diseases. Antihistamines including astemizole (AST) have been reported to present cardiovascular toxicity; however, it remains unclear how 5-FU-mediated cardiotoxicity is affected by AST during the treatment of colon cancer. This study explored the role of AST in 5-FU-induced cardiotoxicity in colon cancer.

Silibinin alleviates acute liver failure by modulating AKT/GSK3β/Nrf2/GPX4 pathway.

Silibinin (Sil) is a major bioactive component of silymarin, extracted from the fruit and seeds of Silybum marianum. Silibinin meglumine (SM) is a water-soluble derivative of silibinin that has shown significant potential in liver fibrosis. However, the potential effects and underlying mechanisms of SM on acute liver failure (ALF) are still not fully understood.

Targeting Synthesis of Diatomic Catalysts by Selective Etching and Sequential Adsorption of Metal Atom.

Diatomic catalysts featuring a tunable structure and synergetic effects hold great promise for various reactions. However, their precise construction with specific configurations and diverse metal combinations is still challenging. Here, a selective etching and metal ion adsorption strategy is proposed to accurately assign a second metal atom (M) geminal to the single atom site (M-N) for constructing diatomic sites (e.

Machine Learning for In-hospital Mortality Prediction in Critically Ill Patients With Acute Heart Failure: A Retrospective Analysis Based on the MIMIC-IV Database.

Background: The incidence, mortality, and readmission rates for acute heart failure (AHF) are high, and the in-hospital mortality for AHF patients in the intensive care unit (ICU) is higher. However, there is currently no method to accurately predict the mortality of AHF patients.

Methods: The Medical Information Mart for Intensive Care Ⅳ (MIMIC-Ⅳ) database was used to perform a retrospective study.

[Clinical and genetic analysis of a child with Lamb-Shaffer syndrome due to a de novo variant of SOX5 gene].

Objective: To explore the clinical features of a child with Lamb-Shaffer syndrome (LAMSHF) due to a variant of SOX5 gene.

Methods: A child who was admitted to Children's Hospital Affiliated to Zhengzhou University in July 2022 was selected as the study subject. Clinical data of the child was collected.

[Clinical significance of trisomy 7 signaled by non-invasive prenatal testing and a literature review].

Objective: To explore the clinical significance of trisomy 7 signaled by non-invasive prenatal testing (NIPT).

Methods: Pregnant women with high risk for trisomy 7 by NIPT from January 2017 to December 2023 were selected as the study subjects, and the results of prenatal diagnosis and follow-up were analyzed. Literature related to pregnant women with a high risk for trisomy 7 by NIPT from January 2016 to July 2024 was retrieved from China Biomedical Literature Database, Wanfang Database, China National Knowledge Infrastructure and PubMed database.

Association between urinary metallothionein concentration and causes of death among cadmium-exposed residents in Japan: a 35-year follow-up study.

Background: As research progresses, there is a growing body of evidence indicating that urinary metallothionein (MT) levels may be elevated in individuals exposed to cadmium (Cd). This study aimed to investigate the potential association between urinary MT levels and causes of mortality among residents of the Kakehashi River Basin who have been exposed to Cd.

Method: The study involved a total of 1,398 men and 1,731 women were conducted between 1981 and 1982, with follow-up until November 2016.

Relationship between physicochemical properties, non-volatile substances, and microbial diversity during the processing of dry-cured Spanish mackerel.

To meet the demand of consumers for high-quality dry-cured fish. This study investigates the relationship between microbial diversity and the changes in physicochemical properties and non-volatile flavor compounds of dry-cured Spanish mackerel (DCSM) throughout the curing process. Our findings demonstrate that moisture content significantly decreased during curing, while NaCl generally increased.

Unlocking dual-mode enzyme activities on bacterial surface: Directional recognition and swift capture of Alicyclobacillus acidoterrestris from fruit juices.

The acidophilic and heat-resistant characteristics of Alicyclobacillus acidoterrestris (A. acidoterrestris) pose significant challenges to fruit juice production. Traditional thermal removal methods are often ineffective against this resilient bacterium.

Prediction of individual total amino acids and free amino acids in Chinese Holstein cows milk using mid-infrared spectroscopy and their phenotypic variability.

Establishing a high-throughput detection technology for amino acid (AA) content in milk using mid-infrared (MIR) spectroscopy has profound implications for enhancing nutritional value of milk, identifying superior milk sources, producing specialty dairy products, and expanding Dairy Herd Improvement (DHI) metrics. The aim of this study was to evaluate the effectiveness of MIR spectroscopy in predicting the content of 15 individual total AA (TAAs) and 16 free AA (FAAs) in bovine milk as well as to investigate the major factors affecting the phenotypic variability of AA content. From March 2023 to March 2024, 513 milk samples were collected from 10 Holstein dairy farms in China and analyzed using Bentley spectrometers for MIR measurements.

Characterization of heparin interactions with Clostridioides difficile toxins and its potential as anti-CDI therapeutics.

Clostridioides difficile (C. difficile) infection (CDI) is a life-threatening healthcare-associated infection occurring worldwide. C.

An antimicrobial and adhesive conductive chitosan quaternary ammonium salt hydrogel dressing for combined electrical stimulation and photothermal treatment to promote wound healing.

The aim of this study is to investigate the effect of the adhesive, conductive hydrogel on wound healing when used as a therapeutic dressing. Herein, a dressing of PVA/QCS/TP@Fe (PQTF) was designed and prepared integrating polyvinyl alcohol (PVA), chitosan quaternary ammonium salt (QCS), tea polyphenol (TP), and ferric ions (Fe) by a simple one-pot and freeze-thaw method. In view of the comprehensive properties of PQTF hydrogel, including adhesion, electrical conductivity, and swelling performance, PQTF was selected for subsequent in vitro and in vivo healing promotion studies.

Formation of the rosette-like starch with enhanced V-type crystallization via modified solvent-shifting method.

This research investigated the effect modified solvent-shifting method on the formation, ordered structure, and morphology of V-type starch. Ionic liquid (IL) dissolution and hot ethanol aqueous incubation in gradient concentrations from 30 % to 80 % (v/v) were applied to optimize the relative crystallinity of V-type starch. The results showed that this new method worked in producing V-type conformation, and higher ethanol concentration tended to yield V-type starch with higher crystallinity and more disk-like shape structure within the ethanol range of 30-50 % (v/v).

Biocompatible dually reinforced gellan gum hydrogels with selective antibacterial activity.

The poor mechanics and functionality of natural-polymer hydrogels from gellan gum (GG) prohibit their practical application, despite the intrinsic thermo-reversible gelation nature, structural and quality consistency, biocompatibility, biodegradability and sustainability of microbial fermentation-produced GG. Herein, a dual-reinforcing strategy, i.e.

Wheat starch-Lonicera caerulea berry polyphenols complex regulates blood glucose and improves intestinal flora in type 2 diabetic mice.

Resistant starch (RS) reduces or delays the digestion of carbohydrates and glucose synthesis, thereby lowering postprandial blood glucose levels. The wheat starch-Lonicera caerulea berry polyphenols (WS-LCBP) complex was constructed using high hydrostatic pressure (HHP). The effects of intragastric administration of WS or WS-LCBP on blood glucose in T2DM model mice.

Development of a rapid enzymatic quantification method for hyaluronic acid based on the gene-mining of hyaluronate lyase.

Hyaluronic acid (HA), a vital polysaccharide naturally present in human tissues, is widely utilized in the food, pharmaceutical and cosmetic industries due to its diverse functionalities and bioactivity. Rapid and accurate quantification of HA is essential for the quality control of its products. Enzymatic quantification methods, known for their simplicity and high specificity, were employed for polysaccharide measurement.

Fabrication of nanocellulose-based high-mechanical and super-hydrophobic xerogels for speedy oil absorbents.

Cellulose-based porous materials are promising for various fields and preferred for sustainable development. However, the low mechanical properties and high hydrophilicity of cellulose-based xerogels had a direct influence on their application in oil absorption. To address the challenge, an environmentally friendly and economical method for synthesizing MTMS/C0.

Oligosaccharide-assisted resolution of holothurian fucosylated chondroitin sulfate for fine structure and P-selectin inhibition.

Fucosylated chondroitin sulfate (FCS) from Holothuria mexicana (FCS) was selected for investigation because of its intriguing branch features. Selective β-eliminative depolymerization and the bottom-up assembly were performed to unravel that FCS consisted of a {D-GlcA-β1,3-D-GalNAc} backbone and branches of alternating Fuc (55 %) and D-GalNAc-α1,2-L-Fuc (45 %), the highest proportion of disaccharide branch reported to date. In branches, sulfation could occur at every free -OH site except O-3 of GalNAc, being the most complex and various structure features of natural FCS.

The Space Radiobiological Exposure Facility on the China Space Station.

The Space Radiobiological Exposure Facility (SREF) is a general experimental facility at the China Space Station for scientific research in the fields of space radiation protection, space radiation biology, biotechnology, and the origin of life. The facility provides an environment with controllable temperatures for experiments with organic molecules and model organisms such as small animals, plant seeds, and microorganisms. The cultivation of small animals can be achieved in the facility with the use of microfluidic chips and images and videos of such experiments can be captured by microscopy.

Sugar boiling pre-treatment improves radio frequency explosion puffing quality on modifying the physicochemical and functional properties of purple sweet potato flour.

The effects of sugar boiling pretreatment (SBP) with different maltitol concentrations (20 %, 30 %, and 40 %) and boiling time (0 - 6 min) on the physicochemical and functional properties of purple sweet potato flour and the radiofrequency explosion puffing (RFEP) quality were investigated. The results showed that the volume ratio, crispness, anthocyanin retention rate and overall acceptability of the samples were maximized after boiling for 6 min at 40 % maltitol concentration achieving increases of 78.63 %, 437.

Integrated transcriptome and metabolome analysis revealed molecular regulatory mechanism of saline-alkali stress tolerance and identified bHLH142 in winter rapeseed (Brassica rapa).

Soil salinization is one of the main problems leading to a reduction in arable land area. In the present study, strongly salt-tolerant lines were screened for germination rates and physiological indices. The mechanism of saline-alkali stress tolerance in winter rapeseed was examined using transcriptome and metabolome analyses.