Predicting axillary lymph node metastasis in breast cancer using a multimodal radiomics and deep learning model.

Objective: To explore the value of combined radiomics and deep learning models using different machine learning algorithms based on mammography (MG) and magnetic resonance imaging (MRI) for predicting axillary lymph node metastasis (ALNM) in breast cancer (BC). The objective is to provide guidance for developing scientifically individualized treatment plans, assessing prognosis, and planning preoperative interventions.

Methods: A retrospective analysis was conducted on clinical and imaging data from 270 patients with BC confirmed by surgical pathology at the Third Hospital of Shanxi Medical University between November 2022 and April 2024.

Age-related unstable transient states and imbalanced activation proportion of brain networks in people with autism spectrum disorder: A resting-state fMRI study using coactivation pattern analyses.

The atypical static brain functions related to the executive control network (ECN), default mode network (DMN), and salience network (SN) in people with autism spectrum disorder (ASD) has been widely reported. However, their transient functions in ASD are not clear. We aim to identify transient network states (TNSs) using coactivation pattern (CAP) analysis to characterize the age-related atypical transient functions in ASD.

Phenotype prediction in plants is improved by integrating large-scale transcriptomic datasets.

Research on the dynamic expression of genes in plants is important for understanding different biological processes. We used the large amounts of transcriptomic data from various plant sample sources that are publicly available to investigate whether the expression levels of a subset of highly variable genes (HVGs) can be used to accurately identify the phenotypes of plants. Using maize ( L.

Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies.

Introduction: Alopecia is a systemic disease with multiple contributing factors. Effective treatment is challenging when only hair growth mechanisms are targeted while ignoring the role of maintaining hair follicle microenvironment homeostasis, which is crucial for cell growth and angiogenesis. Oxidative stress and inflammation are major disruptors of this microenvironment, leading to inhibited cell proliferation and compromised hair follicle circulation.

Injectable Polyhydroxyalkanoate-Nano-Clay Microcarriers Loaded with r-BMSCs Enhance the Repair of Cranial Defects in Rats.

Purpose: Successful regeneration of cranial defects necessitates the use of porous bone fillers to facilitate cell proliferation and nutrient diffusion. Open porous microspheres, characterized by their high specific surface area and osteo-inductive properties, offer an optimal microenvironment for cell ingrowth and efficient ossification, potentially accelerating bone regeneration.

Materials And Methods: An in vitro investigation was conducted to assess the physicochemical properties, porosity, and biocompatibility of PHA-nano-clay open porous microspheres.

High-Speed Sequential DNA Computing Using a Solid-State DNA Origami Register.

DNA computing leverages molecular reactions to achieve diverse information processing functions. Recently developed DNA origami registers, which could be integrated with DNA computing circuits, allow signal transmission between these circuits, enabling DNA circuits to perform complex tasks in a sequential manner, thereby enhancing the programming space and compatibility with various biomolecules of DNA computing. However, these registers support only single-write operations, and the signal transfer involves cumbersome and time-consuming register movements, limiting the speed of sequential computing.

Hydrophilic Ethylene Glycol Fragments: A Determinant Affecting the Therapeutic Index of Paclitaxel Prodrug Nanoassemblies.

Prodrug-based nanoassemblies are promising platforms for cancer therapy. Prodrugs typically consist of three main components: drug modules, intelligent response modules, and modification modules. However, the available modification modules are usually hydrophobic aliphatic side chains, which affect the activation efficiency of the prodrugs.

Study protocol: A national cross-sectional study on psychology and behavior investigation of Chinese residents in 2023.

Introduction: This study protocol specifies the primary research line and theoretical framework of the 2023 Survey of the Psychology and Behavior of the Chinese Population. It aims to establish a consistent database of Chinese residents' psychological and behavioral surveys through multi-center and large-sample cross-sectional surveys to provide robust data support for developing research in related fields. It will track the public's physical and psychological health more comprehensively and systematically.

N6-methyladenosine-modified long non-coding RNA promotes stemness and sorafenib resistance in hepatocellular carcinoma by upregulating SHOX2 expression.

Background: Hepatocellular carcinoma (HCC) is a prevalent and aggressive tumor. Sorafenib is the first-line treatment for patients with advanced HCC, but resistance to sorafenib has become a significant challenge in this therapy. Cancer stem cells play a crucial role in sorafenib resistance in HCC.

Prognostic value of preoperative systemic immune-inflammation index/albumin for patients with hepatocellular carcinoma undergoing curative resection.

Background: Hepatocellular carcinoma (HCC) is a major factor for cancer-associated mortality globally. Although the systemic immune-inflammation index (SII) and albumin (ALB) show individual prognostic value for various cancers, their combined significance (SII/ALB) in HCC patients undergoing curative hepatectomy is still unknown. It is hypothesized that a higher SII/ALB ratio correlates with poorer outcomes with regard to overall survival (OS) and recurrence-free survival (RFS).

Loss of Fascin2 increases susceptibility to cisplatin-induced hearing impairment and cochlear cell apoptosis in mice.

Objectives: Deletion of gene in mice has been linked to progressive hearing loss and degeneration of cochlear cells. Cisplatin, an antitumor drug, can cause various side effects, including ototoxicity. The aim of this study was to investigate the effects of on cisplatin-induced hearing impairment in mice and to explore the possible mechanism.

Achieving Linear α-Macro-olefins in Ethylene Polymerization through Precisely Tuned Bis(imino)pyridylcobalt Precatalysts with Steric and Electronic Parameters.

Synthesis of functional polyethylene from ethylene alone is tricky and heavily dependent on both the type and structure of the precatalyst and the choice of cocatalyst used in the polymerization. In the present study, a series of cobalt precatalysts was prepared and investigated for ethylene polymerization under various conditions. By incorporation of strong electron-withdrawing groups (F and NO) and a steric component (benzhydryl) into the parent bis(imino)pyridine ligand, the catalytic performance of these precatalysts was optimized.

Relationship between chronic endometritis and fallopian tube obstruction and its influence on pregnancy outcome after fallopian tubal recanalization.

Background: Chronic endometritis (CE), frequently asymptomatic, is associated with female infertility. Fallopian tube obstruction (FTO) is also one of the factors contributing to female infertility. More than 90% of cases of proximal FTO can be successfully treated after fallopian tubal recanalization (FTR) and the spontaneous pregnancy rate of treated women after FTR is only about 30%.

A Case Report of Meningitis Caused by Biovar 3.

Background: Brucellosis, a major endemic disease in northern China, is contracted by zoonosis of . We report a case of meningitis caused by biovar 3.

Case Presentation: A 46-year-old man was hospitalized at a local medical facility due to symptoms of fever, soreness, and weakness on April 16, 2021.

First Documented Successful Treatment of Chronic Postoperative Fungal Endophthalmitis Induced by with Fluconazole.

This report details an uncommon occurrence of chronic endophthalmitis following cataract surgery attributed to an infection by Trichosporon inkin (T. inkin). The infection was identified through MALDI-TOF mass spectrometry along with sequencing analysis.

Stimuli-responsive hydrogels for bone tissue engineering.

The treatment of bone defects remains a great clinical challenge. With the development of science and technology, bone tissue engineering technology has emerged, which can mimic the structure and function of natural bone tissues and create solutions for repairing or replacing human bone tissues based on biocompatible materials, cells and bioactive factors. Hydrogels are favoured by researchers due to their high water content, degradability and good biocompatibility.

The use of hydrogel microspheres as cell and drug delivery carriers for bone, cartilage, and soft tissue regeneration.

Bone, cartilage, and soft tissue regeneration is a complex process involving many cellular activities across various cell types. Autografts remain the "gold standard" for the regeneration of these tissues. However, the use of autografts is associated with many disadvantages, including donor scarcity, the requirement of multiple surgeries, and the risk of infection.

Placental cord insertion migration: Implications for ultrasound documentation and follow-up of abnormal placental cord insertion site.

Introduction/purpose: It is well-documented in the literature that the placenta migrates during pregnancy; however, studies regarding placental cord insertion (PCI) migration are scarce. This longitudinal, prospective study aimed to determine whether PCI migration is a true phenomenon, to assess whether the PCI can change classification during pregnancy and to determine the validity of PCI site documentation including follow-up of abnormal PCI.

Methods: Eighty-three participants who had first, second and third trimester ultrasound examinations at a Western Australian private imaging practice over a 12-month period between November 2021 and November 2022 were recruited.

The Big Chip: Challenge, model and architecture.

As Moore's Law comes to an end, the implementation of high-performance chips through transistor scaling has become increasingly challenging. To improve performance, increasing the chip area to integrate more transistors has become an essential approach. However, due to restrictions such as the maximum reticle area, cost, and manufacturing yield, the chip's area cannot be continuously increased, and it encounters what is known as the "area-wall".

Diagnostic value of digital continuous bowel sounds in critically ill patients with acute gastrointestinal injury: A prospective observational study.

Background: Acute gastrointestinal injury (AGI) is common in intensive care unit (ICU) and worsens the prognosis of critically ill patients. The four-point grading system proposed by the European Society of Intensive Care Medicine is subjective and lacks specificity. Therefore, a more objective method is required to evaluate and determine the grade of gastrointestinal dysfunction in this patient population.

Pathogenic Factor Analysis of Shoulder Periarthritis and Design of Virtual Reality Exercise Intervention System.

Shoulder periarthritis, a prevalent musculoskeletal disorder, causes significant pain and functional impairment, severely affecting patients' quality of life. With the increasing incidence of shoulder periarthritis linked to modern lifestyle changes, effective prevention and treatment strategies remain elusive. This study explores two areas: first, identifying risk factors for shoulder periarthritis through Mendelian randomization (MR) analysis, and second, designing a motion intervention system incorporating MediaPipe and virtual reality (VR) technology.

Measurements of Objective Cyclotorsion in a Population of Healthy Children.

This study aimed to compare ocular torsion measurements to investigate normative objective cyclotorsion values in a population of healthy, full-term and preterm children. The participants enrolled in this study had an age range of 3-12 years and were divided into two groups, full-term (gestational age (GA) > 37 weeks) and preterm without retinopathy of prematurity (ROP) (GA ≤ 37 weeks). The disc-center-fovea angle (DFA) was used to evaluate ocular torsion using two different imaging modalities: optical coherence tomography (OCT) with a 55-degree field of view (FV) and conventional fundus photography (CFP) with a 45-degree FV.