Publications by authors named "Sumrati Gurtoo"
Article Synopsis
- Hypoxic-ischemic encephalopathy (HIE) is a serious condition in newborns, resulting in high mortality and severe developmental issues in affected infants.
- Traditional methods of assessing brain injury often misjudge the severity, delaying necessary treatments, which highlights the need for better diagnostic tools.
- The study utilized proteomic techniques to identify 51 specific proteins in the serum and urine of HIE neonates, potentially serving as biomarkers for early detection and monitoring of brain injury, thus aiming to improve outcomes and reduce complications.
Aim: Hypoxic Ischemic Encephalopathy (HIE) is one of the principal causes of neonatal mortality and long-term morbidity worldwide. The neonatal signs of mild cerebral injury are subtle, making an early precise diagnosis difficult. Delayed detection, poor prognosis, and lack of specific biomarkers for the disease are increasing mortality rates.
View Article and Find Full Text PDFNeo-antigens presented on cell surface play a pivotal role in the success of immunotherapies. Peptides derived from mutant proteins are thought to be the primary source of neo-antigens presented on the surface of cancer cells. Mutation data from cancer genome sequencing is often used to predict cancer neo-antigens.
View Article and Find Full Text PDFUNC-5 Homolog B (UNC5B) is a member of the dependence receptor family. This family of receptors can induce two opposite intracellular signaling cascades depending on the presence or absence of the ligand and is thus capable of driving two opposing processes. UNC5B signaling has been implicated in several cancers, where it induces cell death in the absence of its ligand Netrin-1 and promotes cell survival in its presence.
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