The Z-enoate Assisted Meyer-Schuster Rearrangement with Thiol Nucleophiles. An Approach for the Functionalized Vinyl Sulfides, and Sulfones.

Vinyl sulfides and their sulfones act as very important building blocks in organic synthesis. Further they are prevalent in bioactive natural and unnatural products and exhibit diverse bioactivities. Here in we report a Z-enoate assisted Meyer-Schuster rearrangement approach for the rapid generation of 1,4-ketoester based vinyl sulfides.

Synthesis of Functionalized Pyrimidines from Propargylic alcohols and their Derivatives: Two Decades of Developments.

Pyrimidine is a six-membered diaza-heterocycle i. e., 1,3-diazine.