Bulky glycocalyx drives cancer invasiveness by modulating substrate-specific adhesion.

The majority of the eukaryotic cell surface is decorated with a layer of membrane-attached polysaccharides and glycoproteins collectively referred to as the glycocalyx. While the formation of a bulky glycocalyx has been associated with the cancer progression, the mechanisms by which the glycocalyx regulates cancer invasiveness are incompletely understood. We address this question by first documenting subtype-specific expression of the major glycocalyx glycoprotein Mucin-1 (MUC1) in breast cancer patient samples and breast cancer cell lines.

Nuclear α-actinin-4 regulates breast cancer invasiveness and EMT.

Epithelial-to-mesenchymal transition (EMT) is a key process where cells lose their adhesion properties and augment their invasive properties. α-Actinin4 (ACTN4) is an actin crosslinking protein that responds to mechanical stimuli and is found to be elevated in breast cancer patients. While ACTN4 has been implicated in regulating cancer invasiveness by modulating cytoskeletal organization, its nuclear functions remain much less explored.

MHD free convection with Joule heating and entropy generation inside an -shaped hollow structure.

In this research, a free convective flow of water inside an -shaped hollow structure which is subjected to the existence of an exterior magnetic field and Joule heating is computationally investigated. The structure's right and left upright surfaces are maintained at invariant ambient thermal condition, while the top and bottom-most surfaces of the structure are in adiabatic condition. The rest of the inner walls are heated isothermally.

Revisiting thermo-physical property models of AlO-Water nanofluid for natural convective flow.

One of the comprehensive ways of heat transport performance augmentation of thermo-fluid systems is to use nanofluid over base fluid. This study mainly scrutinizes several existing models of thermal conduction coefficient and absolute viscosity of AlO-water nanofluid with the experimental data. A benchmark problem of natural convective flow is selected to test the performance of the available nanofluid models.

Optimization of system parameters during conjugate mixed convective flow in a square domain with an oscillating spinning cylinder.

A computational analysis has been executed to analyze the combined conduction-mixed convection heat transfer of a rotationally oscillating solid cylinder in a differentially heated square box filled with air. The conjugate mixed convective flow initiates the heat transfer process, where the left-side boundary is isothermally kept to a higher temperature, and the right-side boundary is maintained at a lower temperature. Conduction heat transfer takes place inside the solid cylinder.

Multi-scaling analysis of turbulent boundary layers over an isothermally heated flat plate with zero pressure gradient.

A meticulous investigation into turbulent boundary layers over an isothermally heated flat plate with zero pressure gradient has been conducted. Eight distinct turbulence models, including algebraic yPlus, standard , standard , length-velocity, Spalart-Allmaras, low Reynolds number , shear stress transport, and turbulence models, are carefully chosen for numerical simulation alongside thermal energy and Reynolds-Averaged Navier-Stokes equations. A comparative analysis has determined that the Spalart-Allmaras model exhibits remarkable agreement with the results from direct numerical simulation, making it a reliable tool for predicting turbulent heat transfer and fluid flow, particularly at higher Prandtl and Reynolds numbers.

CFD analysis of heat transfer enhancement by wall mounted flexible flow modulators in a channel with pulsatile flow.

The aim of the present study is to explore heat transfer and pressure drop characteristics in a pulsating channel flow due to wall-mounted flexible flow modulators (FFM). Cold air in pulsating fashion is forced to enter through the channel having isothermally heated top and bottom walls with one/multiple FFMs mounted on them. The dynamic conditions of pulsating inflow are characterized by Reynolds number, non-dimensional pulsation frequency and amplitude.

ICT-based solution for efficient fecal sludge management: An experience from Bangladesh.

In Bangladesh, people primarily depend on on-site sanitation facilities (OSSF) with an immense challenge in achieving safe sanitation due to unplanned infrastructure development, improper management of fecal sludge, and inadequate monitoring. The commitment of attaining Sustainable Development Goals (SDG) 6.2 (ensuring safe sanitation for all) by 2030 requires immediate attention in the management of fecal sludge for low-middle income countries.

Particle deposition and fluid flow characteristics in turbulent corrugated pipe flow using Eulerian-Lagrangian approach.

A numerical simulation of aerosol particle deposition in a horizontal circular pipe with a corrugated wall under turbulent flow has been carried out in this research. This paper uses the RNG - turbulence model with Enhanced Wall Treatment to simulate fluid flow. Furthermore, the Lagrangian particle tracking model simulates particle deposition in the corrugated pipe.

Entropy generation and characteristics of mixed convection in lid-driven trapezoidal tilted enclosure filled with nanofluid.

The investigation of steady, incompressible, laminar mixed convective fluid flow within two different types of tilted lid-driven trapezoidal enclosures filled with nanofluid composed of water and AlO nanoparticles has been carried out in this paper. The upper wall of the enclosure is an isothermal cold surface that travels at a constant speed, while the bottom surface of the cavity maintains a constant high temperature. Non-dimensional governing equations along with the appropriate boundary conditions are solved using Galerkin finite element technique.

Conjugate mixed convection heat transfer with internal heat generation in a lid-driven enclosure with spinning solid cylinder.

The current study investigates conjugate mixed convection heat transmission with internal heat generation in a square enclosure driven by a sliding lid and a solid cylinder with a heat-conducting surface at its center. The enclosure has a stationary bottom wall that is kept at a constant hot temperature and a cold upper wall that moves consistently. The solid cylinder rotates both clockwise and counterclockwise at different angular speeds.

Successful endovascular treatment of spontaneous intrarenal pseudoaneurysm in a case of tuberous sclerosis.

Tuberous sclerosis is a complex disorder which has multisystem involvement and varied clinical manifestations. Almost half of the patients have associated angiomyolipoma which contains fat, vascular and smooth muscle components. Spontaneous pseudoaneurysm formation is a complication of angiomyolipoma.