The early effects of segmental surgery on the human pulp.

The teeth of two patients requiring preprosthetic segmental surgery were removed between 4 and 10 weeks postoperatively. The pulps of these teeth were examined histologically using sound teeth from patients of the same age as controls and it was generally found that the teeth from the repositioned segment retained their vitality; there was progressive degeneration of nerves except for the nonmyelinated nerves of the autonomac nervous system, which remained intact.

The management of patients with the Kasabach-Merritt syndrome.

The Kasabach-Merritt syndrome comprises consumption coagulation associated with giant haemangioma. A case is reported of disseminated intravascular coagulation complicating dental extraction in a 36-year-old male with this syndrome. The pre-operative management with anticoagulant therapy is discussed and the relevant literature reviewed.

Oral surgery in general dental practice. Apicoectomy.

Apicoectomy is a frequently performed operation. In order to produce consistently good results the operation and its varieties are described, with stress being placed on correct assessment of each case prior to surgery.

Oral surgery in general dental practice. The removal of malpositioned premolars and canines.

Malposed mandibular and maxillary premolars and canines often cause great difficulties in removal. The ways in which these procedures are accomplished are described in detail.

Oral surgery in general dental practice. The removal of roots.

The removal of fractured teeth and retained tooth roots is described in a systematic fashion, with emphasis being placed on such procedures being carried out in general practice. The discussion is aimed at producing sound treatment planning and sequential action in order to achieve best results for patient and surgeon.

Temporo-mandibular joint ankylosis and oro-nasal fistula as complications of facial trauma.

Condylar fractures with or without disruption of the temporo-mandibular joint occur commonly with other facial injuries. The subsequent development of ankylosis presents surgical and anaesthetic problems in management and results in severe physical disability to the patient. Oro-nasal fistula is a rare complication of fractures involving the middle third of the facial skeleton, and two cases are reported.

The effect of two soluble thalidomide derivatives on lymphocyte stimulation.

The soluble thalidomide derivatives, 1-(morpholinomethyl)-4-phthalimido-piperidindione-2,6 (CG603) and its isomer 1-(morpholinomethyl)-3-phthalimido-piperidindione-2,6 (CG601) have been found to inhibit the production of transformed cells in 90-hr mixed lymphocyte cultures from two unrelated human donors. In 72-hr phytohaemagglutinin cultures however, the incorporation of thymidine into the acid insoluble fraction was not inhibited by the same concentration of drugs. Since the initial event in the mixed lymphocyte reaction is considered to be immunological whereas the response to phytohaemagglutinin is not, one possible explanation is that the compounds act by blocking a step in the lymphocyte stimulation pathway between the reception of the antigen, and the site where the phytohaemagglutinin bypass is effective.