Understanding the current provisions of support for people with an intellectual disabilities and/or autism in crisis: A mixed methods study.

Background: There has been significant reduction in inpatient beds for people with intellectual disability and/or autism (PwID/A) in the UK in the last decade following high profile national scandals in specialist psychiatric hospitals. To reduce inappropriate admissions a new strategy (Blue-Light, an emergency multi-disciplinary meeting to prevent admission to hospital) was introduced. However, there is no research on the influence of Blue-Light on crisis management for PwID/A.

Impact of primary care triage using the Head and Neck Cancer Risk Calculator version 2 on tertiary head and neck services in the post-coronavirus disease 2019 period.

Objective: This study investigates the impact of primary care utilisation of a symptom-based head and neck cancer risk calculator (Head and Neck Cancer Risk Calculator version 2) in the post-coronavirus disease 2019 period on the number of primary care referrals and cancer diagnoses.

Methods: The number of referrals from April 2019 to August 2019 and from April 2020 to July 2020 (pre-calculator) was compared with the number from the period January 2021 to August 2022 (post-calculator) using the chi-square test. The patients' characteristics, referral urgency, triage outcome, Head and Neck Cancer Risk Calculator version 2 score and cancer diagnosis were recorded.

The psychological and social impact of the digital self-support system 'Brain in Hand' on autistic people: prospective cohort study in England and Wales.

Background: Brain in Hand (BIH) is a UK-based digital self-support system for managing anxiety and social functioning.

Aims: To identify the impact of BIH on the psychological and social functioning of adults with autism.

Method: Adults with diagnosed or suspected DSM-5 (level 1) autism, identified by seven NHS autism services in England and Wales, were recruited for a 12-week prospective mixed-methods cohort study.

Simulation translation differences between craft groups.

Background: Many simulation-based clinical education events (SBCEE) aim to prepare healthcare professionals with the knowledge, skills, and features of professionalism needed to deliver quality patient care. However, how these SBCEE learnings are translated into broader workplace practices by learners from different craft groups has not been described.

Objectives: To understand how learners from different craft groups (doctors and nurses) anticipate simulation-based learnings will translate to their workplaces and the process by which translation occurs.

An MRI study of solute transport in the intervertebral disc.

Objective: Quantitative magnetic resonance imaging was used to determine partition coefficients and characteristic time constants for diffusion of MRI contrast agents in disc tissue.

Materials And Methods: Twenty-two excised equine intervertebral discs were exposed to a range of contrast agents: six to manganese chloride, eight to Magnevist (gadopentetate dimeglumine) and eight to Gadovist (gadobutrol), and uptake into the disc was quantified in T-weighted images.

Results: Diffusion for all contrast agents was approximately 25% faster in the nucleus than in the outer annulus; disc-average time constants ranged from (2.

Investigation of changes in bone density and chemical composition associated with bone marrow oedema-type appearances in magnetic resonance images of the equine forelimb.

Background: The aetiology of bone marrow oedema-like abnormalities (BMOA) seen on magnetic resonance imaging (MRI) is as yet not fully understood. The current study aimed to investigate the potential of projection radiography and Raman microspectroscopy to provide information regarding the underlying physiological changes associated with BMOA in equine bone samples.

Methods: MRI was used to assess 65 limbs from 43 horses.

A simulation environment for studying transcutaneous electrotactile stimulation.

Transcutaneous electrical nerve stimulation (TENS) allows the artificial excitation of nerve fibres by applying electric-current pulses through electrodes on the skin's surface. This work involves the development of a simulation environment that can be used for studying transcutaneous electrotactile stimulation and its dependence on electrode layout and excitation patterns. Using an eight-electrode array implementation, it is shown how nerves located at different depths and with different orientations respond to specific injected currents, allowing the replication of already reported experimental findings and the creation of new hypotheses about the tactile sensations associated with certain stimulation patterns.

Structure of the Pacinian Corpuscle: Insights Provided by Improved Mechanical Modeling.

An improved model of the Pacinian corpuscle includes corrections for lamellar curvature. Results suggest that outer-zone lamellae produce a focusing effect whereby stimuli are channeled radially inwards. The requirements for this effect (large outer-surface area and thin, closely spaced lamellae) provide a rationale for the complexity of the outer-zone structure.

Using interprofessional simulation to improve collaborative competences for nursing, physiotherapy, and respiratory therapy students.

Within the care of people living with respiratory conditions, nursing, physiotherapy, and respiratory therapy healthcare professionals routinely work in interprofessional teams. To help students prepare for their future professional roles, there is a need for them to be involved in interprofessional education. The purpose of this project was to compare two different methods of patient simulation in improving interprofessional competencies for students in nursing, physiotherapy, and respiratory therapy programmes.

Lomustine Nanoparticles Enable Both Bone Marrow Sparing and High Brain Drug Levels - A Strategy for Brain Cancer Treatments.

Purpose: The blood brain barrier compromises glioblastoma chemotherapy. However high blood concentrations of lipophilic, alkylating drugs result in brain uptake, but cause myelosuppression. We hypothesised that nanoparticles could achieve therapeutic brain concentrations without dose-limiting myelosuppression.

Montage of a Queering Deferred: Memory, Ownership, and Archival Silencing in the Rhetorical Biography of Langston Hughes.

This article explores the intersection of archival privilege and heteronormative bias in the queering of Langston Hughes. Although it has been a common belief in LGBTQ communities that Hughes was gay, the battle over how his sexuality is defined in various biographical texts involves broader issues of dominant representations of sexuality and who gets to speak for those no longer able to speak for themselves. As such, the article examines the texts Looking for Langston and The Life of Langston Hughes as well as the discourses that surrounded both.

Multi-modal representation of effector modality in frontal cortex during rule switching.

We report a functional magnetic resonance imaging (fMRI) study which investigated whether brain areas involved in updating task rules within the frontal lobe of the cerebral cortex show activity related to the modality of motor response used in the task. Participants performed a rule switching task using different effector modalities. In some blocks participants responded with left/right button presses, whilst in other blocks left/right saccades were required.

Surface-Roughness-Based Virtual Textiles: Evaluation Using a Multi-Contactor Display.

Virtual textiles, generated in response to exploratory movements, are presented to the fingertip via a 24-contactor vibrotactile array. Software models are based on surface-roughness profiles from real textiles. Results suggest that distinguishable "textile-like" surfaces are produced, but these lack the necessary accuracy for reliable matching to real textiles.

An acoustic double fishnet using Helmholtz resonators.

The acoustic transmission of a closely spaced pair of patterned and perforated rigid plates is explored in air. The structure resembles an acoustic double fishnet design, with each plate modified such that the gap between them acts as an array of Helmholtz resonators. This allows the center frequency of the stop band to be reduced by a factor greater than 2 from the value obtained for the conventional acoustic double fishnet design.

Control of the stop band of an acoustic double fishnet.

The acoustic transmittance of two closely spaced solid plates, each perforated with a square array of cylindrical holes, exhibits a band of near-perfect acoustic attenuation originating from hybridization between a resonance in the gap separating the plates and pipe resonances in the holes. Displacement of one plate relative to the other, such that the holes are no longer aligned, or an increase in the plate separation leads to an increased center frequency of the stop band. This ability to easily tune the frequency of the stop band may prove advantageous.

Fatal disseminated fusarium infection in a human immunodeficiency virus positive patient.

Systemic mycotic infections have been increasing in incidence in immunocompromised patients. Although yeasts are most often isolated, opportunistic fungal infections may also be caused by filamentous fungi, including Aspergillus and Fusarium. Like Aspergillus, Fusarium is angioinvasive with an ability to disseminate widely.

A functional-magnetic-resonance-imaging investigation of cortical activation from moving vibrotactile stimuli on the fingertip.

Using a 100-element tactile stimulator on the fingertip during functional-magnetic-resonance imaging, brain areas were identified that were selectively activated by a moving vibrotactile stimulus (the sensation of a moving line being dragged over the fingertip). Activation patterns elicited by tactile motion, contrasted to an equivalent stationary stimulus, were compared in six human subjects with those generated by a moving visual stimulus, contrasted to an equivalent stationary stimulus. Results provide further evidence for a neuroanatomical convergence of tactile-motion processing and visual-motion processing in humans.

Discrimination of interval size in short tone sequences.

This study investigates the discrimination of small changes of interval size in short sequences of musical tones. Major, minor and neutral thirds were varied in increments of 15 cents. The nine subjects had varying degrees of amateur musical experience-their level of musical training was lower than that of professional musicians.

The role of the lateral prefrontal cortex and anterior cingulate in stimulus-response association reversals.

Many complex tasks require us to flexibly switch between behavioral rules, associations, and strategies. The prefrontal cerebral cortex is thought to be critical to the performance of such behaviors, although the relative contribution of different components of this structure and associated subcortical regions are not fully understood. We used functional magnetic resonance imaging to measure brain activity during a simple task which required repeated reversals of a rule linking a colored cue and a left/right motor response.

Semantic divergence and creative story generation: an fMRI investigation.

The aim of this fMRI investigation was to identify those areas of the brain associated with approaching a story generation task creatively and to investigate the effects upon these correlates of incorporating a set of words that were unrelated to each other-a strategy considered to encourage semantic divergence. Preliminary experiments were undertaken to investigate the possible confounding effects of the scanner environment upon creativity and to reveal the effects of creative effort and word relatedness upon the creativity of those who would be participating in the fMRI scan. In the final part of the investigation, a factorial fMRI design was used to elucidate brain regions involved in increased creative effort and also the effect upon activity in these regions when participants incorporated words that bore little semantic relationship with each other.

Specific training in clinical forensic medicine is useful to ACEM trainees.

Objective: To assess the effectiveness of a 6-month rotation in forensic medicine in developing medicolegal and forensic skills for doctors training for a fellowship with the Australasian College for Emergency Medicine (ACEM).

Methods: Over a period of 6 years 12 trainees undertook a 6-month rotation with the Victorian Institute of Forensic Medicine (VIFM) as a clinical forensic registrar. These 12 trainees were surveyed and asked structured questions regarding their perception of the usefulness of the training and the impact of the rotation on their professional development.

Information content and quality of MR thumb images.

This study investigates the relation between objective and subjective parameters which relate to the quality of magnetic-resonance images, with a view to developing procedures for minimizing imaging time. The investigation uses high-resolution images of the thumb as example. Detection thresholds for an artificial lesion and ratings of image quality were obtained for a variety of images, with several experienced observers.