Publications by authors named "Summer Singh"
Article Synopsis
- Researchers have mapped base substitution mutations in the E. coli thyA gene, cataloging 343 mutations across 232 base pairs, significantly expanding the available mutational sites compared to the rpoB/Rif system.
- The study identified specific transition and transversion rates for various nucleotide changes, providing a detailed framework for monitoring mutational patterns.
- It also highlighted "hot" mutational regions in the gene, suggesting that the gene's structural properties may influence mutation frequency.
We report the mutational spectra in a segment of the E. coli rpoB gene of bleomycin (BLEO), 4-nitroquinoline-1-oxide (NQO), and hydrogen peroxide (HO). We compare these spectra with those of other mutagens and repair deficient strains in the same rpoB system, and review the key elements determining mutational hotspots and outline the questions that remain unanswered.
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