Craniofacial allometry in the OIM mouse model of osteogenesis imperfecta.

Osteogenesis imperfecta (OI) is a skeletal disorder characterized by the impaired synthesis of type I collagen (Col1). This study tests the hypothesis that the craniofacial phenotype of severe OI is linked to an overall reduction in body size. 3D landmark data were collected from µCT scans of adult OIM and wild-type (WT) mice and used to calculate centroid sizes (CS) and interlandmark distances (ILDs).