Dysregulated epidermal growth factor and tumor growth factor-beta receptor signaling through protein interaction in liver fibrosis.

Objective: Viral hepatitis is associated with high morbidity and mortality. Identification of biological pathways involved in hepatic fibrosis resulting from chronic hepatitis C are essential for better management of patients. Constructing the -human protein interaction network through bioinformatics may enable us to discover diagnostic biological pathways.

Immunoexpression of Cyclin D1 and PTEN in Various Endometrial Pathologies.

Objective: To determine the expression of cyclin D1 and PTEN (phosphatase and tensin homolog) in endometrial hyperplasias and neoplasias.

Study Design: Analytical study.

Place And Duration Of Study: The study was conducted at BMSI, JPMC, Karachi, from January 2008 to December 2012.

Differential expression of phophatase and tensin homologue in normal, hyperplastic and neoplastic endometrium.

Objectives: To observe the differential expression of phophatase and tensin homologue in normal proliferative, hyperplastic and malignant endometrial lesions.

Methods: .The retrospective study was based on the analysis of endometrial samples, both hysterectomies and curettage, received at the department of pathology Basic Medical Sciences Institute at the Jinnah Postgraduate Medical Centre, Karachi, from January 1, 2006 to December 31, 2010.

Differential expression of p63 in hydropic and molar gestations.

Objective: To observe the differential expression of p63 in hydropic and molar gestation.

Study Design: Cross-sectional analytical study.

Place And Duration Of Study: Department of Pathology, Basic Medical Sciences Institute, Jinnah Postgraduate and Medical Centre, Karachi, from January 2006 to June 2013.