Publications by authors named "Sumit Kumar Dey"
Macropinocytosis is a cellular process that enables cells to engulf extracellular material, such as nutrients, growth factors, and even whole cells. It is involved in several physiological functions as well as pathological conditions. In cancer cells, macropinocytosis plays a crucial role in promoting tumor growth and survival under nutrient-limited conditions.
View Article and Find Full Text PDFPhosphorus (P) demand is likely to increase especially in legumes to harness greater benefits of nitrogen fixation under elevated CO condition. In the following study, seed yield and seed P uptake in cowpea increased by 26.8% and 20.
View Article and Find Full Text PDFStructural oscillations and solvation dynamics in the mitochondria of a live cell are studied by time-resolved microscopy using a covalent fluorescence probe. We compared the dynamics in a human breast cancer cell (MCF-7) with that in a normal breast cell MCF-10A. The probe, CPM (7-diethylamino-3-(4-maleimido-phenyl)-4-methylcoumarin), binds with the free thiol groups.
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- A gold (I) N-heterocyclic complex, referred to as complex 3, was synthesized and evaluated for its effectiveness against melanoma cells, showing promising cytotoxicity and anti-cancer properties.
- The study employed various methods including MTT assays, flow cytometry, and western blotting to analyze its impact on cancer cell viability, apoptosis markers, and signaling pathways.
- Results indicated that complex 3 not only inhibited cancer cell growth and induced apoptosis through mitochondrial pathways but also reduced tumor size in mice, while affecting key proteins involved in cell survival and death, like p53 and NF-κB.
Anticancer role of andrographolide is well documented. To find novel potent derivatives with improved cytotoxicity than andrographolide on cancer cells, two series of di-spiropyrrolidino- and di-spiropyrrolizidino oxindole andrographolide derivatives prepared by cyclo-addition of azomethine ylide along with sarcosine or proline (viz. sarcosine and proline series respectively) and substitution of different functional groups (-CH3, -OCH3 and halogens) were examined for their cytotoxic effect on a panel of six human cancer cell lines (colorectal carcinoma HCT116 cells, pancreatic carcinoma MiaPaCa-2 cells, hepatocarcinoma HepG2 cells, cervical carcinoma HeLa cells, lung carcinoma A549 and melanoma A375 cells).
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