Publications by authors named "Sumit Dey"

Background And Objectives: In the era of precision medicine, genetic test results have become increasingly relevant in the care of patients with Parkinson disease (PD). While large research consortia are performing widespread research genetic testing to accelerate discoveries, debate continues about whether, and to what extent, the results should be returned to patients. Ethically, it is imperative to keep participants informed, especially when findings are potentially actionable.

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  • The study focuses on finding a cost-effective way to treat Urinary Bladder Cancer (UBC) by using a combination of disulfiram (DSF) and copper gluconate (Cu) alongside traditional chemotherapy in a mouse model.
  • Male C57BL/6J mice were exposed to a chemical known to induce UBC, and their treatment included various drug combinations, with significant evaluations performed on tumor formation and molecular expressions.
  • Results showed that the DSF-Cu combination significantly reduced tumor size and burden, lowered levels of specific cancer-related enzymes, and indicated enhanced autophagy, showing potential for improved treatment strategies in UBC.
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 Neurosurgical patients often receive 0.9% normal saline (NS) during the perioperative period. Theoretically, a balanced salt solution (BSS) is better than 0.

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Macropinocytosis is a cellular process that enables cells to engulf extracellular material, such as nutrients, growth factors, and even whole cells. It is involved in several physiological functions as well as pathological conditions. In cancer cells, macropinocytosis plays a crucial role in promoting tumor growth and survival under nutrient-limited conditions.

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A feeding trial spanning two months was conducted to evaluate the effects of sp on growth performance, water quality, survival, proximate composition and biochemical profile of common carp () where fishmeal was partially replaced using sp in the diet. Twenty uniform-sized common carp fries were distributed into triplicate groups and placed in 40-liter rectangular glass tanks. sp.

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The dataset includes a comparative analysis of sp. and sp. to characterize their productivity, proximate composition, biochemical composition and pigments.

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Cyanobacteria are regarded as vital constituents of aquatic ecosystems which recently become viable option for bioremediation since it can remove contaminants from polluted water. They possess intriguing metabolic properties and exhibit differential growth patterns. This study elucidates the isolation and identification of two marine and two freshwater indigenous spp.

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Cyanobacterial species such as spp. pigments are essential components that enable the photosynthetic ability of this autotrophic organism. These pigments, principally chlorophylls and phycobiliproteins, are crucial for photosynthesis and give cyanobacteria their distinctive blue-green color.

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Objectives To evaluate and compare different polygenic risk score (PRS) models in predicting Parkinsons disease (PD) across diverse ancestries, focusing on identifying the most suitable approach for each population and potentially contributing to equitable advancements in precision medicine. Methods We constructed a total of 105 PRS across individual level data from seven diverse ancestries. First, a cross-ancestry conventional PRS comparison was implemented by utilizing the 90 known European risk loci with weighted effects from four independent summary statistics including European, East Asian, Latino/Admixed American, and African/Admixed.

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  • The study investigates the antibacterial effects of phenolic extracts from marine and freshwater species, focusing on various strains of Gram-positive and Gram-negative bacteria.
  • Results show that filamentous species exhibited significantly higher antibacterial activity than their planktonic counterparts, with the strongest inhibition observed in filamentous species against specific Gram-positive bacteria.
  • The findings highlight the potential of these species to produce bioactive compounds for developing new antibiotics, benefiting both the aquaculture and pharmaceutical sectors.
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Pharmacological activation of nuclear factor erythroid 2 related factor 2 (NRF2) provides protection against several environmental diseases by inhibiting oxidative and inflammatory injury. Besides high in protein and minerals, leaves contain several bioactive compounds, predominantly isothiocyanate moringin and polyphenols, which are potent inducers of NRF2. Hence, leaves represent a valuable food source that could be developed as a functional food for targeting NRF2 signaling.

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  • * A virtual 3-day hackathon brought together 49 early-career scientists from 12 countries, focusing on building tools and pipelines specifically for PD research, with each team working on one of nine distinct projects.
  • * The hackathon not only generated resources to enhance research but also provided training and networking opportunities, ultimately fostering creative problem-solving and collaboration essential for emerging researchers in data science.
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Using particulate matter (PM) mass as exposure metric does not reveal the intrinsic PM chemical characteristics or toxic potential, which is crucial for monitoring the sources of emission causing adverse health effects and developing risk mitigating strategies. Oxidative stress and ensuing lipid peroxidation (LPO) in the lung are crucial underlying mechanisms of action by which PM drives cardiorespiratory disease. In the current study, we have postulated and demonstrated that the intrinsic potential of PM to elicit LPO, defined as "LPO index" as a novel approach for characterizing oxidative potential of PM (PM) and predicting biological toxicity.

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Tacrolimus is a narrow therapeutic index drug. As a result, regulatory agencies worldwide recommend stringent bioequivalence evaluation criteria for approval of generics. Despite this, the professional transplantation societies have raised concerns over the safety and efficacy of generic substitutions.

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Introduction: Programmed cell death-1/programmed cell death ligand-1 (PD-1/PDL-1) inhibitors are the newest class of approved drugs for advanced urothelial cancer (AdUC). This review aims to collate the evidence for their efficacy and safety in various treatment settings.

Methods: Extensive search of databases was performed (updated May 2018) and the protocol was registered on PROSPERO (CRD42017081568).

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Though many cancers are known to show up-regulation of nonmuscle myosin (NM) IIA and IIB, the mechanism by which NMIIs aid in cancer development remains unexplored. Here we demonstrate that tumor-generating, fibroblast-like cells isolated from 3-methylcholanthrene (3MC)-induced murine tumor exhibit distinct phospho-dependent localization of NMIIA and NMIIB at the perinuclear area and tip of the filopodia and affect cell migration differentially. While NMIIA-KD affects protrusion dynamics and increases cell directionality, NMIIB-KD lowers migration speed and increases filopodial branching.

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Phosphorus (P) demand is likely to increase especially in legumes to harness greater benefits of nitrogen fixation under elevated CO condition. In the following study, seed yield and seed P uptake in cowpea increased by 26.8% and 20.

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  • The α-alkylation of ketones is a key reaction in chemistry, especially for creating compounds that have significant natural and medicinal applications.
  • The authors previously introduced a new enantioselective method using N-amino cyclic carbamate (ACC) auxiliaries, which has shown to be more effective than traditional methods.
  • This text presents a comprehensive discussion of their studies and findings related to the ACC ketone α-alkylation technique, emphasizing its high enantioselectivity and yield.
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The septation initiation network (SIN), comprising a GTPase and a cascade of three protein kinases, regulates cell division in fission yeast , but questions remain about its influence on cytokinesis. Here, we made quantitative measurements of the numbers of Cdc7p kinase molecules (a marker for SIN activity) on spindle pole bodies (SPBs), and on the timing of assembly, maturation and constriction of contractile rings via six different proteins tagged with fluorescent proteins. When SIN activity is low in mutant cells at 32°C, cytokinetic nodes formed contractile rings ∼3 min slower than wild-type cells.

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Bleb formation has been correlated with nonmuscle myosin II (NM-II) activity. Whether three isoforms of NM-II (NM-IIA, -IIB and -IIC) have the same or differential roles in bleb formation is not well understood. Here we report that ectopically expressed, GFP-tagged NM-II isoforms exhibit different types of membrane protrusions, such as multiple blebs, lamellipodia, combinations of both, or absence of any such protrusions in MCF-7 cells.

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Background: For a long time cancer cells are known for increased uptake of glucose and its metabolization through glycolysis. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key regulatory enzyme of this pathway and can produce ATP through oxidative level of phosphorylation. Previously, we reported that GAPDH purified from a variety of malignant tissues, but not from normal tissues, was strongly inactivated by a normal metabolite, methylglyoxal (MG).

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Enveloped viruses enter host cells through membrane fusion and the cells in turn alter their shape to accommodate components of the virus. However, the role of nonmuscle myosin II of the actomyosin complex of host cells in membrane fusion is yet to be understood. Herein, we show that both (-) blebbistatin, a specific inhibitor of nonmuscle myosin II (NMII) and small interfering RNA markedly augment fusion of Sendai virus (SeV), with chinese hamster ovary cells and human hepatocarcinoma cells.

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3-Methylcholanthrene (3MC) induces tumor formation at the site of injection in the hind leg of mice within 110 days. Recent reports reveal that the transformation of normal muscle cells to atypical cells is one of the causes for tumor formation, however the molecular mechanism behind this process is not well understood. Here, we show in an in vitro study that 3MC induces fragmentation of multinucleate myotubes into viable mononucleates.

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