Publications by authors named "Sumire Shimada"
Article Synopsis
- The study tested the effectiveness of liquid phenol-based chemical peeling therapy for treating cervical and vaginal intraepithelial neoplasia (CIN and VaIN) to avoid complications from surgical procedures.
- Out of 483 women, the therapy showed promising results with less than 2% of treated patients experiencing persistent disease compared to significantly higher rates in untreated patients.
- Factors like immune suppression, age (35-39 years), and high-grade lesions were linked to treatment resistance, but overall, no obstetric complications arose in pregnancies following the therapy.
The aim of this study was to measure the concentrations of enrofloxacin (ERFX) and other fluoroquinolones; orbifloxacin (OBFX), marbofloxacin (MBFX), and ofloxacin (OFLX) in the plasma and bile of rabbits after a single intravenous (IV) injection. Twenty male rabbits were divided into four groups and given each drug by IV injection into the ear vein at a dose of 5.0 mg/kg BW.
View Article and Find Full Text PDFBackground: Tofogliflozin is a highly selective sodium-glucose co-transporter 2 (SGLT2) inhibitor. A mass balance study with combinations of microdoses revealed that tofogliflozin has high oral bioavailability (97.5%) and that tofogliflozin in circulation is eliminated primarily by metabolic pathways, with the liver playing a prominent role in elimination.
View Article and Find Full Text PDFTofogliflozin is a selective oral inhibitor of sodium-glucose co-transporter 2 for treatment of type 2 diabetes mellitus. The pharmacokinetics, pharmacodynamics, and safety of tofogliflozin were investigated in healthy male subjects. Three studies were conducted: single-ascending dose study (10-640 mg) in 56 Japanese and 24 Caucasian subjects; multiple-ascending dose study (2.
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