Neurite Damage in Patients with Migraine.

We examined neurite orientation dispersion and density imaging in patients with migraine. We found that patients with medication overuse headache exhibited lower orientation dispersion than those without. Moreover, orientation dispersion in the body of the corpus callosum was statistically negatively correlated with migraine attack frequencies.

Brain Microstructure and Brain Function Changes in Space Headache by Head-Down-Tilted Bed Rest.

Several astronauts have experienced severe headaches during spaceflight, but no studies have examined the associated brain microstructure and functional changes. Head-down-tilted bed rest (HDBR) is a well-established method for studying the physical effects of microgravity on the ground. In this study, we analyzed the changes in brain microstructure and function during headache caused by HDBR using diffusion tensor imaging (DTI) and resting state functional magnetic resonance imaging (R-fMRI).

The Modifying of Functional Connectivity Induced by Peripheral Nerve Field Stimulation using Electroacupuncture for Migraine: A Prospective Clinical Study.

Objective: We examined the functional connectivity (FC) in patients with migraine compared with healthy subjects before and after C2 peripheral nerve field stimulation with electroacupuncture (EA-C2-PNfS) to evaluate the effect of EA-C2-PNfS and elucidate the mechanism of migraine.

Methods: Twenty-six patients with migraine and 24 healthy controls were recruited. All patients underwent resting state functional magnetic resonance imaging before and after 3 months of EA-C2-PNfS.

White matter diffusion abnormalities in migraine and medication overuse headache: A 1.5-T tract-based spatial statistics study.

Objectives: Migraine and medication overuse headache are common, but its pathophysiology remains unclear. Differential diagnosis of chronic headache is still challenging. Conventional brain imaging techniques exclude secondary causes of headache but cannot produce a proper diagnosis.

Clinical Effect of C2 Peripheral Nerve Field Stimulation Using Electroacupuncture for Primary Headache.

Objective: We applied C2 peripheral nerve field stimulation using electroacupuncture (EA-C2-PNfS) for primary headache, and investigated its clinical effectiveness.

Materials And Methods: Fifty-four primary headache patients (10 men, 44 women) with a mean age of 48.6 ± 15.