Publications by authors named "Sumio Ikenoue"

Attenuation of the secondary injury of spinal cord injury (SCI) can suppress the spread of spinal cord tissue damage, possibly resulting in spinal cord sparing that can improve functional prognoses. Granulocyte colony-stimulating factor (G-CSF) is a haematological cytokine commonly used to treat neutropenia. Previous reports have shown that G-CSF promotes functional recovery in rodent models of SCI.

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Background: The open-door laminoplasty has been used to treat cervical spondylotic myelopathy. This technique has been applied to the surgical treatment of thoracic and lumbar spinal canal tumors instead of simple laminectomy or hemilaminectomy. However, previously reported laminoplasty methods did not keep posterior supporting elements intact such as the laminae and the spinous processes with supraspinous and interspinous ligaments, and almost all of them needed instruments for the fixation of reconstructed laminae.

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Article Synopsis
  • G-CSF, typically used for treating neutropaenia, shows potential for enhancing neurological recovery after spinal cord injuries, leading to further clinical trial phases.
  • A current phase III clinical trial is underway to assess G-CSF's efficacy for acute spinal cord injury, involving 88 patients split into treatment and placebo groups, with motor function assessed over 3 months.
  • The study adheres to ethical guidelines and regulations, ensuring transparent reporting of results, regardless of whether they are positive or negative.
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Fractures of the axis are considered to be one of the most common injuries to the cervical spine, accounting for more than 20% of all cervical spine fractures. Multiple fractures of the axis are much rarer, accounting for 1% of all cervical fractures. Management of such complex fractures is still challenging, and there is no strong consensus for the treatment.

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