Protein phosphatase 2A regulates blood cell proliferation and differentiation in Drosophila larval lymph glands.

Protein phosphatase 2A (PP2A), one of the most abundant protein phosphatases, has divergent functions in multiple types of cells. Its inactivation has been closely associated with leukemia diseases. However, the physiological function of PP2A for hematopoiesis has been poorly understood in organisms.

Metabolic strategy of macrophages under homeostasis or immune stress in .

Macrophages are well known for their phagocytic functions in innate immunity across species. In mammals, they rapidly consume a large amount of energy by shifting their metabolism from mitochondrial oxidative phosphorylation toward aerobic glycolysis, to perform the effective bactericidal function upon infection. Meanwhile, they strive for sufficient energy resources by restricting systemic metabolism.

Regulation of Hematopoiesis in Lymph Gland: From a Developmental Signaling Point of View.

The hematopoietic system is becoming increasingly attractive for its simple blood cell lineage and its developmental and functional parallels with the vertebrate system. As the dedicated organ for larval hematopoiesis, the lymph gland harbors both multipotent stem-like progenitor cells and differentiated blood cells. The balance between progenitor maintenance and differentiation in the lymph gland must be precisely and tightly controlled.

A photoelectrochemical sensing strategy based on single-layer MoS modified electrode for methionine detection.

MoS, a typical transition metal disulfide, is widely used in the photoelectrochemical (PEC) sensor construction. In general, MoS based PEC sensor are "signal-on" strategies. Surprisingly, we discovered that the PEC response of MoS was quenched by methionine greatly.