Publications by authors named "Sumin He"
[Baicalin inhibits the activity of keratinocytes in psoriasis by activating Notch signaling pathway].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
May 2019
Objective To investigate the effect of baicalin on the viability and cell cycle of psoriatic keratinocytes and its possible mechanism. Methods MTT assay was used to detect the viability of keratinocytes treated by 0, 10, 50, 100, 200, 300 μg/mL baicalin for 48 hours. The cell cycle and apoptotic rate were detected by flow cytometry.
View Article and Find Full Text PDFPsoriasis is a common inflammatory skin disease with genetic components of both immune system and the epidermis. PSOR1 locus (6q21) has been strongly associated with psoriasis; however, it is difficult to identify additional independent association due to strong linkage disequilibrium in the MHC region. We performed stepwise regression analyses of more than 3,000 SNPs in the MHC region genotyped using Human 610-Quad (Illumina) in 1,139 cases with psoriasis and 1,132 controls of Han Chinese population to search for additional independent association.
View Article and Find Full Text PDFThe distribution of complement component 4 (C4) gene copy number (GCN) has been validated in European populations. Meanwhile, C4 gene has been identified as a susceptibility gene for systemic lupus erythematosus (SLE). However, the association and the possible phenotype significance remain to be determined intensely in the Chinese population.
View Article and Find Full Text PDFGenome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population.
Nat Genet
June 2011
Article Synopsis
- Atopic dermatitis is a long-lasting inflammatory skin condition influenced by both genetics and the environment.
- A study involved a genome-wide analysis of atopic dermatitis in a large Chinese Han population and included additional samples from Germany, leading to the identification of new genetic markers associated with the condition.
- The findings reveal new potential genetic factors that contribute to atopic dermatitis and suggest new biological pathways that could be explored for better understanding and treatment.
Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6.
J Invest Dermatol
May 2011
A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OR(Overall) = 1.21 (1.
View Article and Find Full Text PDFBackground: Chromosomal region 16p13 has been reported to harbour variants associated with several autoimmune diseases, including type I diabetes, rheumatoid arthritis and multiple sclerosis.
Objective: To test whether variants in the 16p13 region are also associated with systemic lupus erythematosus (SLE) by performing a candidate locus study in the Chinese Han population.
Methods: Tag single nucleotide polymorphisms (SNPs) encompassing 50 kb upstream and downstream of the 250 kb linkage disequilibrium block, previously implicated in several autoimmune diseases, were analysed in 1047 patients with SLE and 1205 controls.
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.
Nat Genet
July 2010
Article Synopsis
- - We conducted a genome-wide association study for generalized vitiligo focusing on the Chinese Han population, involving over 1,100 cases and almost 1,500 controls, followed by a larger replication study in different Chinese populations.
- - Two significant genetic markers in the major histocompatibility complex (MHC) region were identified, one associated with increased risk (rs11966200) and another potentially protective (rs9468925) related to specific HLA alleles.
- - Additionally, we discovered a new risk locus at 6q27 (rs2236313) linked to three genes, contributing to a better understanding of the genetic factors involved in vitiligo.
Background: The narrow host range of Mycobacterium leprae and the fact that it is refractory to growth in culture has limited research on and the biologic understanding of leprosy. Host genetic factors are thought to influence susceptibility to infection as well as disease progression.
Methods: We performed a two-stage genomewide association study by genotyping 706 patients and 1225 controls using the Human610-Quad BeadChip (Illumina).
Article Synopsis
- Keloids are benign tumors of the skin, and their development may be influenced by human HLA status, but research on Chinese Han individuals has been limited.
- The study analyzed HLA class I alleles in 192 keloid patients and 252 healthy controls using the PCR-SSP method, revealing significant differences in allele frequencies between the two groups.
- High-risk haplotypes linked to keloids were identified, and the results suggest that specific HLA alleles could be genetic risk factors for developing keloids.
Article Synopsis
- A specialized DNA biochip was developed to detect specific base substitution mutations in mitochondrial DNA linked to MELAS and MERRF syndromes.
- The biochip utilized a multiplex PCR method to amplify DNA from patients and healthy controls, optimizing detection parameters for accuracy.
- Results confirmed known mutations in patients with MELAS and MERRF, matching DNA sequencing results, suggesting the biochip could be an effective clinical screening tool for mtDNA mutations.