Publications by authors named "Sumiaki Matsumoto"

Background: Computed tomography (CT) has important roles for lung cancer screening, and therefore radiation dose reduction by using iterative reconstruction technique and scanning methods receive widespread attention.

Purpose: To evaluate the effect of two reconstruction techniques (filtered back projection [FBP] and adaptive iterative dose reduction using three-dimensional processing [AIDR 3D]) and two acquisition techniques (wide-volume scan [WVS] and helical scan as 64-detector-row CT [64HS]) on the lung nodule identifications of using a chest phantom.

Material And Methods: A chest CT phantom including lung nodules was scanned using WVS and 64HS at nine different tube currents (TCs; range, 270-10 mA).

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Purpose: To prospectively compare the diagnostic capability of diffusion-weighted MR imaging obtained with fast advantage spin-echo sequence (FASE-DWI) and echo planar imaging sequence (EPI-DWI), short inversion time inversion recovery fast advanced spin-echo (STIR FASE) imaging and FDG PET/CT for N-stage assessment of non-small cell carcinoma (NSCLC) patients.

Materials And Methods: 95 consecutive operable NSCLC patients underwent STIR FASE imaging, FASE-DWI and EPI-DWI with a 3T system, integrated PET/CT, surgical treatment and pathological and follow-up examinations. Probability of lymph node metastasis was visually assessed using a 5-point visual scoring system.

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Purpose: To compare predictive capabilities of non-contrast-enhanced (CE)- and dynamic CE-perfusion MRIs, thin-section multidetector computed tomography (CT) (MDCT), and perfusion scan for postoperative lung function in non-small cell lung cancer (NSCLC) patients.

Materials And Methods: Sixty consecutive pathologically diagnosed NSCLC patients were included and prospectively underwent thin-section MDCT, non-CE-, and dynamic CE-perfusion MRIs and perfusion scan, and had their pre- and postoperative forced expiratory volume in one second (FEV1 ) measured. Postoperative percent FEV1 (po%FEV1 ) was then predicted from the fractional lung volume determined on semiquantitatively assessed non-CE- and dynamic CE-perfusion MRIs, from the functional lung volumes determined on quantitative CT, from the number of segments observed on qualitative CT, and from uptakes detected on perfusion scans within total and resected lungs.

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MR imaging has emerged as a major new research and diagnostic tool for various pulmonary diseases, especially lung cancer. State-of-the art thoracic MR imaging now has the potential to be used as a substitute for traditional imaging techniques and/or to play a complementary role in patient management. This article focuses on these recent advances in MR imaging for lung cancer imaging, especially for pulmonary nodule assessment, lung cancer staging, postoperative lung function prediction, and prediction and evaluation of therapeutic response and recurrence.

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Purpose: To prospectively compare the capabilities for TNM classification and assessment of clinical stage and operability among whole-body magnetic resonance (MR) imaging, coregistered positron emission tomographic (PET)/MR imaging with and without MR signal intensity (SI) assessment, and integrated fluorine 18 fluorodeoxyglucose (FDG) PET/computed tomography (CT) in non-small cell lung cancer (NSCLC) patients.

Materials And Methods: The institutional review board approved this study, and written informed consent was obtained from each patient. One hundred forty consecutive NSCLC patients (75 men, 65 women; mean age, 72 years) prospectively underwent whole-body MR imaging, FDG PET/CT, conventional radiologic examinations, and surgical, pathologic, and/or follow-up examinations.

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Objectives: To determine the appropriate parameters and evaluation method for characterizing solitary pulmonary nodules (SPNs) using quantitative parameters of diffusion-weighted imaging (DWI).

Methods: Thirty-two subjects with 36 SPNs underwent DWI with seven different b values (0, 50, 100, 150, 300, 500, and 1000s/mm(2)). Five quantitative parameters were obtained from the region of interest drawn over each SPN: apparent diffusion coefficients (ADCs), true diffusion coefficients (DCs), and perfusion fractions (PFs), and signal-intensity ratios between lesion and spinal cord from DWI (b values: 1000 [LSR1000] and 500 [LSR500)]).

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Purpose: To compare primarily viewing axial images (Axial mode) versus coronal reconstruction images (Coronal mode) in computer-aided detection (CAD) of lung nodules on multidetector computed tomography (CT) in terms of detection performance and reading time.

Materials And Methods: Sixty CT data sets from two institutions were collected prospectively. Ten observers (6 radiologists, 4 pulmonologists) with varying degrees of experience interpreted the data sets using CAD as a second reader (performing nodule detection first without then with aid).

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Rationale And Objectives: To evaluate paired inspiratory/expiratory computed tomography (CT; iCT/eCT) and deformable image registration for quantitative and qualitative assessment of airflow limitation in smokers.

Materials And Methods: Paired iCT/eCT images acquired from 35 smokers (30 men and 5 women) were coregistered and subtraction images (air trapping CT images [aCT]) generated. To evaluate emphysema quantitatively, the percentage of low-attenuation volume (LAV%) on iCT was calculated at -950 HU, as were mean and kurtosis on aCT for quantitative assessment of air trapping.

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Purpose: To evaluate the effects of adaptive iterative dose reduction using 3D processing (AIDR 3D) for quantification of two measures of emphysema: percentage of low-attenuation volume (LAV%) and size distribution of low-attenuation lung regions.

Method And Materials: Fifty-two patients who underwent standard-dose (SDCT) and low-dose CT (LDCT)were included. SDCT without AIDR 3D, LDCT without AIDR 3D, and LDCT with AIDR 3D were used for emphysema quantification.

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Purpose: To prospectively compare the capabilities of dynamic perfusion area-detector computed tomography (CT), dynamic magnetic resonance (MR) imaging, and positron emission tomography (PET) combined with CT (PET/CT) with use of fluorine 18 fluorodeoxyglucose (FDG) for the diagnosis of solitary pulmonary nodules.

Materials And Methods: The institutional review board approved this study, and written informed consent was obtained from each subject. A total of 198 consecutive patients with 218 nodules prospectively underwent dynamic perfusion area-detector CT, dynamic MR imaging, FDG PET/CT, and microbacterial and/or pathologic examinations.

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Purpose: To compare the use of dynamic oxygen-enhanced magnetic resonance (MR) imaging with the use of quantitatively assessed computed tomography (CT) for assessment of clinical stage and evaluation of pulmonary functional change due to treatment in patients with asthma.

Materials And Methods: The institutional review board of Kobe University Hospital approved this study, and written informed consent was obtained from each subject. Thirty consecutive patients with asthma (17 men and 13 women; age range, 27-78 years) underwent dynamic oxygen-enhanced MR imaging, multidetector CT, and assessment of forced expiratory volume in 1 second.

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Rationale And Objectives: The purpose of this study was to analyze the relationship between airflow limitation and two types of computed tomography (CT) measurements: expiratory/inspiratory (E/I) ratio and E/I difference of percentage of low-attenuation lung regions (LAA%).

Materials And Methods: Thirty patients who underwent inspiratory and expiratory CT scans were included in this study. The CT data were used to calculate the LAA% E/I ratio and E/I difference.

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Objectives: The aim of this study was to evaluate the utility of the iterative reconstruction (IR) technique for quantitative bronchial assessment during low-dose computed tomography (CT) as a substitute for standard-dose CT in patients with/without chronic obstructive pulmonary disease.

Methods: Fifty patients (mean age, 69.2; mean % predicted FEV1, 79.

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Objective: The purpose of this study was to investigate efficacy of two types of emphysema quantification: percentage of low-attenuation lung regions (%LA); and size distribution of these regions. On a log-log plot, cumulative frequency-size distribution of low-attenuation lung regions can be fitted by a straight line whose slope (D) has been reported to reflect diffusing capacity. In this study, %LA and D were compared with pulmonary function test (PFT) parameters, especially with ratio of diffusing capacity of carbon monoxide to effective alveolar ventilation (i.

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Objective: The purpose of this article is to review advanced imaging of pulmonary nodules, including pathologic and pharmacokinetic background, conventional contrast-enhanced CT and MRI assessment, dynamic contrast-enhanced CT and MRI techniques, and dual-source and area-detector CT systems for pulmonary nodule evaluation.

Conclusion: Clinicians need to understand the underlying principles and pathologic and pharmacokinetic backgrounds of contrast-enhanced CT and MRI to further improve diagnostic performance. With adjustments in image acquisition and postprocessing, contrast-enhanced CT and MRI, especially the dynamic versions, can have enhanced clinical application for pulmonary nodules and expanded clinical relevance for other thoracic diseases.

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Objective: The purpose of this article is to prospectively and directly compare the capabilities of non-contrast-enhanced MR angiography (MRA), 4D contrast-enhanced MRA, and contrast-enhanced MDCT for assessing pulmonary vasculature in patients with non-small cell lung cancer (NSCLC) before surgical treatment.

Subjects And Methods: A total of 77 consecutive patients (41 men and 36 women; mean age, 71 years) with pathologically proven and clinically assessed stage I NSCLC underwent thin-section contrast-enhanced MDCT, non-contrast-enhanced and contrast-enhanced MRA, and surgical treatment. The capability for anomaly assessment of the three methods was independently evaluated by two reviewers using a 5-point visual scoring system, and final assessment for each patient was made by consensus of the two readers.

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Purpose: To prospectively and directly compare oxygen-enhanced (O2-enhanced) MRI with thin-section CT for pulmonary functional loss and disease severity assessment in connective tissue disease (CTD) patients with interstitial lung disease (ILD).

Materials And Methods: Thin-section CT, O2-enhanced MRI, pulmonary function test and serum KL-6 were administered to 36 CTD patients with ILD (23 men, 13 women; mean age: 63.9 years) and nine CTD patients without ILD (six men, and three women; mean age: 62.

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Purpose: To assess the influence of ultrashort TE (UTE) intervals on pulmonary magnetic resonance imaging (MRI) with UTEs (UTE-MRI) for pulmonary functional loss assessment and clinical stage classification of smokers.

Materials And Methods: A total 60 consecutive smokers (43 men and 17 women; mean age 70 years) with and without COPD underwent thin-section multidetector row computed tomography (MDCT), UTE-MRI, and pulmonary functional measurements. For each smoker, UTE-MRI was performed with three different UTE intervals (UTE-MRI A: 0.

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Purpose: The purpose of this study was to compare diagnostic capabilities for assessment of recurrence in non-small cell lung cancer (NSCLC) patients by contrast-enhanced whole-body MRI (CE-WB-MRI) with and without CE-Quick 3D and double RF fat suppression technique (DFS), FDG-PET/CT and conventional radiological examinations.

Materials And Methods: A total of 134 pathologically proven and completely resected NSCLC patients (78 males, 56 females; mean age: 72 years) underwent FDG-PET/CT, CE-WB-MRI with and without Quick 3D and DFS at 3T as well as conventional radiological examinations. The probability of recurrence was assessed with a 5-point scoring system on a per-patient basis, and final diagnosis was made by consensus between two readers.

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Objective: The objective of our study was to prospectively compare the capability of dynamic area-detector CT analyzed with different mathematic methods and PET/CT in the management of pulmonary nodules.

Subjects And Methods: Fifty-two consecutive patients with 96 pulmonary nodules underwent dynamic area-detector CT, PET/CT, and microbacterial or pathologic examinations. All nodules were classified into the following groups: malignant nodules (n = 57), benign nodules with low biologic activity (n = 15), and benign nodules with high biologic activity (n = 24).

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Since the publication of the Radiologic Diagnostic Oncology Group Report in 1991, the clinical application of pulmonary magnetic resonance imaging (MRI) in patients with lung cancer has been limited. In contrast, MRI for lung cancer has undergone continuous development, and several promising techniques have been introduced to overcome the previously suggested limitations. In addition, comparative studies involving multidetector-row computed tomography and positron emission tomography or positron emission tomography/computed tomography with 2-deoxy-2-[F]fluoro-D-glucose have shown useful new clinical applications for MRI in lung cancer.

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Purpose: To evaluate the utility of pulmonary magnetic resonance (MR) imaging with ultra-short echo times (UTEs) at a 3.0 T MR system for pulmonary functional loss and disease severity assessments of connective tissue disease (CTD) patients with interstitial lung disease (ILD).

Materials And Methods: This prospective study was approved by the institutional review board, and written informed consent was obtained from 18 CTD patients (eight men and ten women) and eight normal subjects with suspected chest disease (three men and five women).

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Purpose: To compare the reading times and detection performances of radiologists in concurrent-reader and second-reader modes of computer-aided detection (CAD) for lung nodules on multidetector computed tomography (CT).

Materials And Methods: Fifty clinical multidetector CT datasets containing nodules up to 20mm in diameter were retrospectively collected. For the detection and rating of non-calcified nodules larger than 4mm in diameter, 6 radiologists (3 experienced radiologists and 3 resident radiologists) independently interpreted these datasets twice, once with concurrent-reader CAD and once with second-reader CAD.

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Objective: The purpose of this study was to determine the utility of adaptive iterative dose reduction using 3D processing (AIDR 3D) for image noise reduction and assessment of radiologic findings obtained with reduced- and low-dose chest CT in patients with various pulmonary diseases.

Subjects And Methods: Chest CT examinations at three different tube current settings and using 16- and 64-MDCT scanners were performed for 37 patients. Standard-dose (150 mAs) data were reconstructed as thin-section CT without AIDR 3D, and low-dose (25 mAs) and reduced-dose (50 mAs) data were reconstructed as thin-section CT without and with AIDR 3D.

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Objective: The purpose of our study was to prospectively and directly compare capability of O2-enhanced MRI, MDCT, and perfusion SPECT/CT to clinical outcome measurements in candidates for lung volume reduction surgery (LVRS).

Subjects And Methods: Twenty-five consecutive candidates for LVRS (20 men and five women; age range, 45-76 years) underwent MDCT, O2-enhanced MRI, and perfusion SPECT/CT before and after LVRS. Clinical outcomes for each candidate were evaluated in terms of differences between pre- and postoperative percentage forced expiratory volume in 1 second (%FEV1), Pao2, and 6-minute walking distance.

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