In Vitro Mechanistic Studies of a Standardized Sustainable Grape Seed Extract for Potential Application as a Mood-Modulating and Cognition-Enhancing Supplement.

Background: Grape seed extract (GSE) from L. is rich in polyphenols and oligomeric proanthocyanidin complexes (OPCs), and it has shown potential benefits in managing low mood and cognitive function. In this study, we investigated the potential bioactivities of Enovita, a standardized GSE extract (GSEe herein) rich in OPCs, in key mechanistic pathways related to low mood conditions and cognitive function.

An analysis of an innovative standardized phospholipid carrier-based L extract as a potential neuromodulator for emotional distress and related conditions.

L. (MO), commonly known as lemon balm, a member of the mint family, is considered a calming herb. In various traditional medicines, it has been utilized to reduce stress and anxiety and promote sleep.

The possible "calming effect" of subchronic supplementation of a standardised phospholipid carrier-based . extract in healthy adults with emotional distress and poor sleep conditions: results from a prospective, randomised, double-blinded, placebo-controlled clinical trial.

Emotional distress conditions such as depression, anxiety, stress, and poor sleep are widespread health problems that have a significant impact on people's lives. Conventional drugs are commonly prescribed to treat emotional distress and poor sleep conditions; however, these medications have several limitations and have shown multiple side effects. Over recent years botanicals-based pharmacological agents have gained increasing research and clinical interest in the management of emotional distress and sleep disorder.

Three-Step Test System for the Identification of Novel GABA Receptor Modulating Food Plants.

Potentiation of γ-amino butyric acid (GABA)-induced GABA receptor (GABAR) activation is a common pathway to achieve sedative, sleep-enhancing, anxiolytic, and antidepressant effects. Presently, a three-component test system was established for the identification of novel GABAR modulating food plants. In the first step, potentiation of GABA-induced response of the GABAR was analysed by two-electrode voltage clamp (TEVC) for activity on human α1β2-GABAR expressed in Xenopus laevis oocytes.