Advancing miRNA cancer research through artificial intelligence: from biomarker discovery to therapeutic targeting.

MicroRNAs (miRNAs), a class of small non-coding RNAs, play a vital role in regulating gene expression at the post-transcriptional level. Their discovery has profoundly impacted therapeutic strategies, particularly in cancer treatment, where RNA therapeutics, including miRNA-based targeted therapies, have gained prominence. Advances in RNA sequencing technologies have facilitated a comprehensive exploration of miRNAs-from fundamental research to their diagnostic and prognostic potential in various diseases, notably cancers.

Women's ignorance and misperception of cervical cancer: Evidence-based analysis from low- and middle-income countries.

Cervical cancer is a major cause of morbidity and mortality particularly in low- and mid-income countries. This review synthesizes existing knowledge on cervical cancer, HPV infection, and HPV vaccination accumulated over the past decade (2015-2024), highlighting disparities in awareness and prevention strategies globally. Education level correlates with HPV vaccine awareness, yet mere familiarity with cervical cancer doesn't ensure understanding of its severity.

Reverse pharmacology approach to validate the diabetic wound-healing activity of Jatyadi thailam formulations on diabetic mimic environment.

Objective: Jatyadi thailam, an Ayurvedic preparation, is renowned for its efficacy in diabetic wound healing and inflammation. This study aimed to validate and compare the diabetic wound-healing potential of two Jatyadi thailam formulations - Ayurvedic formulary of India Jatyadi thailam (JT-AFI) and Yogagrantha formulation of Jatyadi thailam (JT-YG), in a diabetic environment using L929 fibroblast cells .

Methodology: The effects on cell survival, proliferation, migration, angiogenesis, cell cycle progression, apoptosis, ROS generation, and mitochondrial function were evaluated.

Defining new biomarkers for overcoming therapeutical resistance in cervical cancer using lncRNA.

Despite improvements in cervical cancer diagnosis and treatment, the prognosis for cervical cancer patients remains dismal due to the development of drug resistance, metastasis, and invasion resulting leading to treatment failure. Long non-coding RNAs (lncRNAs), a class of RNA transcripts have been reported in mediating carcinogenesis as well as drug, and radio-resistance in tumor cells. These lncRNAs regulate various cancer hallmarks and contribute to the development of therapeutic resistance.

Identification of potential probiotics from fermented sour traditional rice varieties and simulation studies.

Fermented products contain probiotic organisms that have beneficial and therapeutic effects on the gastrointestinal tract. The main objective of the study is to isolate probiotic bacteria from fermented sour traditional rice water and to evaluate their probiotic activity. The microbes were isolated from the fermented rice water and the characterization of the organisms was determined using MALDI-TOF MS.

A Review on Deep Learning-driven Drug Discovery: Strategies, Tools and Applications.

It takes an average of 10-15 years to uncover and develop a new drug, and the process is incredibly time-consuming, expensive, difficult, and ineffective. In recent years the dramatic changes in the field of artificial intelligence (AI) have helped to overcome the challenges in the drug discovery pipeline. Artificial intelligence (AI) has taken root in various pharmaceutical sectors, from lead compound identification to clinical trials.

Integrative transcriptome analysis of triple negative breast cancer profiles for identification of druggable targets.

As triple negative breast cancer (TNBC) lacks a specific target, exploration of abnormally expressed genes during the progression of TNBC is important for a better understanding of tumorigenesis and to find a specific target. We intended to figure out genes associated with TNBC, which can provide unique insights into gene dysregulation in TNBC while also pointing to new possible therapeutic targets for TNBC. A meta-analysis of multiple TNBC mRNA profiles was performed to identify consistently differentially expressed genes (CDGs).

Mechanistic Study on Thymoquinone Conjugated ZnO Nanoparticles Mediated Cytotoxicity and Anticancer Activity in Triple-Negative Breast Cancer Cells.

Background: In the current era, the development of molecular techniques involves nano techniques, and the synthesis of nanoparticles is considered the preferred field in nanotechnology.

Objective: The aim of the present work is to analyze the anticancer activity of the thymoquinone conjugated ZnO nanoparticles and understand its mechanism of action in triple-negative breast cancer cell lines MDA-MB-231.

Methods: Zinc Oxide (ZnO) nanoparticles have extensive applications, and it was synthesized using a chemical precipitation method.

Reverse Screening Bioinformatics Approach to Identify Potential Anti Breast Cancer Targets Using Thymoquinone from Neutraceuticals Black Cumin Oil.

Background: Functional foods, neutraceuticals and natural antioxidants have established their potential roles in the protection of human health and diseases. Thymoquinone (TQ), the main bioactive component of Nigella sativa seeds (black cumin seeds), a plant derived neutraceutical was used by ancient Egyptians because of their ability to cure a variety of health conditions and used as a dietary food supplement. Owing to its multi targeting nature, TQ interferes with a wide range of tumorigenic processes and counteracts carcinogenesis, malignant growth, invasion, migration, and angiogenesis.

Cytotoxic activity of the methanolic extract of leaves and rhizomes of Curcuma amada Roxb against breast cancer cell lines.

Objectives: To evaluate the methanol extract of both the leaves and the rhizomes of Curcuma amada (C. amada) for their cytotoxic activity against breast cancer cell lines MCF-7 and MDA MB 231.

Methods: Viability and cytotoxicity induced by the extracts were assessed using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide, sulforhodamine B, and lactate dehydrogenase release assays.