Mid-Infrared Spectroscopy and Multivariate Analysis to Characterize Fermentation Processes.

The ever-growing competition among global biotech industries has led to high demands on production consistency. A statistical strategy of performance mapping for production optimization is therefore of great economic significance. Process analytical technology (PAT)-based sensors such as mid-infrared (MIR) spectroscopy enable process monitoring through substrate and by-product concentrations that directly represent the physiology of cells.