Corrigendum: Identification and metabolomic characterization of potent anti-MRSA phloroglucinol derivatives from Nakai (Polypodiaceae).

[This corrects the article DOI: 10.3389/fphar.2022.

Failure to Thrive: Impaired BDNF Transport along the Cortical-Striatal Axis in Mouse Q140 Neurons of Huntington's Disease.

Boosting trophic support to striatal neurons by increasing levels of brain-derived neurotrophic factor (BDNF) has been considered as a target for therapeutic intervention for several neurodegenerative diseases, including Huntington's disease (HD). To aid in the implementation of such a strategy, a thorough understanding of BDNF cortical-striatal transport is critical to help guide its strategic delivery. In this manuscript, we investigate the dynamic behavior of BDNF transport along the cortical-striatal axis in Q140 primary neurons, a mouse model for HD.

In Silico Protein Folding Prediction of COVID-19 Mutations and Variants.

With its fast-paced mutagenesis, the SARS-CoV-2 Omicron variant has threatened many societies worldwide. Strategies for predicting mutagenesis such as the computational prediction of SARS-CoV-2 structural diversity and its interaction with the human receptor will greatly benefit our understanding of the virus and help develop therapeutics against it. We aim to use protein structure prediction algorithms along with molecular docking to study the effects of various mutations in the Receptor Binding Domain (RBD) of the SARS-CoV-2 and its key interactions with the angiotensin-converting enzyme 2 (ACE-2) receptor.

Identification and metabolomic characterization of potent anti-MRSA phloroglucinol derivatives from Nakai (Polypodiaceae).

Traditional Chinese medicine (TCM) has been used to treat infectious diseases and could offer potential drug leads. This study evaluates the antimicrobial activities from commercially sourced Nakai (Polypodiaceae) whose authenticity was confirmed by DNA barcoding based on the ribulose bisphosphate carboxylase () gene. Powdered rhizomes were sequentially extracted using hexane, dichloromethane, ethyl acetate, and methanol at ambient temperature.

Secondary metabolites of endophytic fungi isolated from Huperzia serrata.

The natural product Huperzine A isolated from Huperzia serrata is a targeted inhibitor of acetylcholinesterase that has been approved for clinical use in the treatment of Alzheimer's disease. Given the large demand for natural sources of Huperzine A  (Hup. A), efforts have been made to explore whether it is also produced by endophytic fungi from H.

Molecular Docking Suggests the Targets of Anti-Mycobacterial Natural Products.

Tuberculosis (TB) is a major global threat, mostly due to the development of antibiotic-resistant forms of the causal agent of the disease. Driven by the pressing need for new anti-mycobacterial agents several natural products (NPs) have been shown to have in vitro activities against . The utility of any NP as a drug lead is augmented when the anti-mycobacterial target(s) is unknown.

Target discovery focused approaches to overcome bottlenecks in the exploitation of antimycobacterial natural products.

Tuberculosis is a major global health hazard. The search for new antimycobacterials has focused on such as screening combinational chemistry libraries or designing chemicals to target predefined pockets of essential bacterial proteins. The relative ineffectiveness of these has led to a reappraisal of natural products for new antimycobacterial drug leads.