Mechanism of Action of Natural Dipeptidyl Peptidase-IV Inhibitors (Berberine and Mangiferin) in Experimentally Induced Diabetes with Metabolic Syndrome.

Background: Berberine (BER) and mangiferin are known natural dipeptidyl peptidase (DPP-IV) inhibitors. Hence, the study was designed to elucidate the mechanism of action of natural DPP-IV inhibitors (BER and MNG) in experimentally induced diabetes with metabolic syndrome.

Aim: The aim of this study was to observe mechanism through which natural DPP-IV inhibitor works in diabetes with metabolic syndrome rat model.

Assessment of lytic cycle and the impact of a gene deletion using 3D label-free optical diffraction holotomography.

is a widespread single-celled intracellular eukaryotic apicomplexan protozoan parasite primarily associated with mammalian foetal impairment and miscarriage, including in humans. Is estimated that approximately one third of the human population worldwide is infected by this parasite. Here we used cutting-edge, label-free 3D quantitative optical diffraction holotomography to capture and evaluate the lytic cycle (invasion, proliferation and egress) in real-time based on the refractive index distribution.

Viewpoints from the National Consultation on Addressing Acute Malnutrition on Mainstreaming Community-Based Program for Management of Acute Malnutrition in India.

High burden of acute malnutrition among children less than 5 years is a major public health problem in India. A "Two-days National Consultation on Addressing Acute Malnutrition" was organized to gather experiences and evidence from 13 states of India on prevention and management of acute malnutrition among children and documenting viewpoints from experts and government counterparts on the same. The consultation centered around five key themes of addressing acute malnutrition; 1) capacity building, 2) strengthening screening, 3) nutritional care of wasting, 4) tracking progress, and 5) scale-up.

Evaluation of changes in ocular surface disease index score and meibomian gland parameters in primary pterygium.

Background: Pterygium is a commonly occurring ocular pathology, characterized by a benign proliferation of conjunctiva which extends onto the corneal surface. Abnormal tear film and meibomian gland (MG) dysfunction have been linked to pterygium development.

Aims: This study was done to evaluate the changes taking place in the Ocular Surface Disease Index (OSDI) score and other tear film parameters with MG parameters in patients of primary pterygium as well as evaluation of the relation between them in pterygium.

Significance of 4D printing for dentistry: Materials, process, and potentials.

Every industry need helps to modify its working style quickly with the improvement of existing technology. New developing technologies improve production speed, reduce industrial process costs, etc. Technical specialists carry out continuous research and development to increase efficiency.

First report of apple stem grooving virus infection in loquat from India.

Loquat, commonly known as , is a major subtropical fruit from the family that is native to China but also found in most of Europe and Asia, including India. Apple stem grooving virus (ASGV) infecting loquat was detected using leaf samples collected from Himachal Pradesh (India) through DAC-ELISA followed by RT-PCR assays targeting coat protein (CP), movement protein (MP) and replicase (Rep) regions of ASGV genome. Sequencing of RT-PCR amplicons and sequence analyses revealed that CP, MP and Rep sequences of ASGV loquat Indian isolate of the current study shared a maximum of 98-100% nucleotide sequence identities with the corresponding sequences of available ASGV Indian isolates [LN559078, HE978837, MZ127820, MN912568].

Mn-doped nickeltitanate (Ni Mn TiO) as a promising support material for PdSn electrocatalysts for methanol oxidation in alkaline media.

Nickeltitanate (Ilmenite) has been prepared with stoichiometric variation by substituting Mn in the 'A' site, using the sol-gel method in a highly active form. The PdSn electrocatalyst was then impregnated with nickeltitanate by a microwave-assisted polyol method. The physiochemical characterisation of the synthesized electrocatalyst PdSn-Ni Mn TiO was done by X-ray diffractometry, UV-visible spectrophotometry, Raman spectroscopy and transmission electron microscopy.

Telemedicine for healthcare: Capabilities, features, barriers, and applications.

Regular hospital visits can be expensive, particularly in rural areas, due to travel costs. In the era of the Covid-19 Pandemic, where physical interaction becomes risky, people prefer telemedicine. Fortunately, medical visits can be reduced when telemedicine services are used through video conferencing or other virtual technologies.

Pedagogy and innovative care tenets in COVID-19 pandemic: An enhancive way through Dentistry 4.0.

The global oral healthcare sector has now woken to implement Dentistry 4.0. The implementation of this revolution is feasible with extensive digital and advanced technologies applications and the adoption of new sets of processes in dentistry & its support areas.

3D Printing Applications for Radiology: An Overview.

Three-dimensional (3D) printing technologies are part of additive manufacturing processes and are used to manufacture a 3D physical model from a digital computer-aided design model as per the required shape and size. These technologies are now used for advanced radiology applications by providing all information through 3D physical model. It provides innovation in radiology for clinical applications, treatment planning, procedural simulation, medical and patient education.

Low-Voltage Nongassing Electroosmotic Pump and Infusion Device with Polyoxometalate-Encapsulated Carbon Nanotubes.

A low-voltage nongassing electroosmotic pump was assembled by sandwiching a silica frit between two carbon paper electrodes that were dip-coated with a paste consisting of phosphomolybdic acid/phosphotungstic acid (PMA/PTA)-encapsulated multiwalled carbon nanotubes (MWCNTs) and Nafion. The PMA/PTA encapsulation was a combined effect of their thermomigration and nanocapillary action in MWCNTs. The encapsulated MWCNTs retained desirable redox and charge transfer characteristics of PMA/PTA.

Central line catheterisation as a cause of vocal cord palsy.

We report an unusual case of vocal cord palsy secondary which developed following insertion of a central line. A 46-year-old gentleman was admitted with seizure activity and reduced GCS. Following failed attempts at establishing intravenous or intraosseous access, a central line was placed into the right internal jugular vein.

Sentiment Analysis of Lockdown in India During COVID-19: A Case Study on Twitter.

With the rapid increase in the use of the Internet, sentiment analysis has become one of the most popular fields of natural language processing (NLP). Using sentiment analysis, the implied emotion in the text can be mined effectively for different occasions. People are using social media to receive and communicate different types of information on a massive scale during COVID-19 outburst.

Quantitative Optical Diffraction Tomography Imaging of Mouse Platelets.

Platelets are specialized anucleate cells that play a major role in hemostasis following vessel injury. More recently, platelets have also been implicated in innate immunity and inflammation by directly interacting with immune cells and releasing proinflammatory signals. It is likely therefore that in certain pathologies, such as chronic parasitic infections and myeloid malignancies, platelets can act as mediators for hemostatic and proinflammatory responses.

Virtual screening, molecular dynamics and structure-activity relationship studies to identify potent approved drugs for Covid-19 treatment.

Computer-aided drug screening by molecular docking, molecular dynamics (MD) and structural-activity relationship (SAR) can offer an efficient approach to identify promising drug repurposing candidates for COVID-19 treatment. In this study, computational screening is performed by molecular docking of 1615 Food and Drug Administration (FDA) approved drugs against the main protease (Mpro) of SARS-CoV-2. Several promising approved drugs, including Simeprevir, Ergotamine, Bromocriptine and Tadalafil, stand out as the best candidates based on their binding energy, fitting score and noncovalent interactions at the binding sites of the receptor.

Significant applications of virtual reality for COVID-19 pandemic.

Background And Aims: During COVID-19 pandemic, researchers are using innovative technologies for fast-tracking the development to end this menace. Virtual Reality (VR) also offers an imperative role for fighting this pandemic, through audiovisual-based virtual communication.

Methods: A brief study on Virtual Reality and its applications for the COVID-19 pandemic is carried out by employing keywords as Virtual reality or VR and COVID-19 from the databases of SCOPUS, Google Scholar, PubMed, Web of science Academia and ResearchGate.

Internet of things (IoT) applications to fight against COVID-19 pandemic.

Background And Aim: The current global challenge of COVID-19 pandemic has surpassed the provincial, radical, conceptual, spiritual, social, and pedagogical boundaries. Internet of Things (IoT) enabled healthcare system is useful for proper monitoring of COVID-19 patients, by employing an interconnected network. This technology helps to increase patient satisfaction and reduces readmission rate in the hospital.

Sustainability of Coronavirus on Different Surfaces.

Coronavirus disease 2019 (COVID-19) is the name of the disease supposedly manifested in December 2019 from Wuhan, from the virus named SARS-CoV-2. Now, this disease has spread to almost all other parts of the world. COVID-19 pandemic has various reasons for its dramatic worldwide increase.

Industry 4.0 technologies and their applications in fighting COVID-19 pandemic.

Background And Aims: COVID 19 (Coronavirus) pandemic has created surge demand for essential healthcare equipment, medicines along with the requirement for advance information technologies applications. Industry 4.0 is known as the fourth industrial revolution, which has the potential to fulfil customised requirement during COVID-19 crisis.

3D printing applications in bone tissue engineering.

Purpose: 3D printing technology provides an excellent capability to manufacture customised implants for patients. Now, its applications are also successful in bone tissue engineering. This paper tries to provide a review of the applications of 3D printing in bone tissue engineering.

Phospholipase D2 in prostate cancer: protein expression changes with Gleason score.

Background: Phospholipases D1 and D2 (PLD1/2) are implicated in tumorigenesis through their generation of the signalling lipid phosphatidic acid and its downstream effects. Inhibition of PLD1 blocks prostate cell growth and colony formation. Here a role for PLD2 in prostate cancer (PCa), the major cancer of men in the western world, is examined.

Voltage-dependent activation of Rac1 by Na 1.5 channels promotes cell migration.

Ion channels can regulate the plasma membrane potential (V ) and cell migration as a result of altered ion flux. However, the mechanism by which V regulates motility remains unclear. Here, we show that the Na 1.

Cardiovascular risk in an HIV-infected population in India.

Objective: To characterise prevalence of traditional cardiovascular disease (CVD) risk factors, assess CVD risk and examine the effect of simulated interventions on CVD risk among HIV-infected Asian Indians.

Methods: Cross-sectional data between September 2015 and July 2016 wer used to describe the prevalence of CVD risk factors. Five risk scores (Framingham, Data Collection on Adverse Effects of Anti-HIV Drugs Study (D:A:D), Atherosclerotic Cardiovascular, QRISK2 and Ramathibodi-Electricity Generating Authority of Thailand were used to estimate CVD risk.

Characterising live cell behaviour: Traditional label-free and quantitative phase imaging approaches.

Label-free imaging uses inherent contrast mechanisms within cells to create image contrast without introducing dyes/labels, which may confound results. Quantitative phase imaging is label-free and offers higher content and contrast compared to traditional techniques. High-contrast images facilitate generation of individual cell metrics via more robust segmentation and tracking, enabling formation of a label-free dynamic phenotype describing cell-to-cell heterogeneity and temporal changes.