Publications by authors named "Sumalatha Kuppireddi"
Salmonella Typhimurium is a major cause of human gastroenteritis. The Salmonella type III secretory system secretes virulence proteins, called effectors. Effectors are responsible for the alteration of tight junction (TJ) structure and function in intestinal epithelial cells.
View Article and Find Full Text PDFArticle Synopsis
- Wild-type Salmonella typhimurium triggers acute intestinal inflammation by activating the NF-kappaB pathway and also degrades beta-catenin, which regulates cellular growth.
- The study shows that Salmonella infection leads to reduced association between NF-kappaB and beta-catenin and alters gene expression related to inflammation, increasing pro-inflammatory cytokines like IL-6.
- GSK-3beta activity is heightened during Salmonella infection, impacting beta-catenin and IkappaBalpha stability, suggesting that beta-catenin may play a new role in suppressing inflammation.
2B4 belongs to the CD2 subset of the IgG family of receptors. Members in this family have been shown to function as coreceptors via homophilic or heterophilic interactions. Both 2B4 and CD2 bind to CD48, another member of this family.
View Article and Find Full Text PDF