Are all charge-transfer parameters created equally? A study of functional dependence and excited-state charge-transfer quantification across two dye families.

Small molecule organic dyes have many potential uses in medicine, textiles, forensics, and light-harvesting technology. Being able to computationally predict the spectroscopic properties of these dyes could greatly expedite screening efforts, saving time and materials. Time-dependent density functional theory (TD-DFT) has been shown to be a good tool for this in many instances, but characterizing electronic excitations with charge-transfer (CT) character has historically been challenging and can be highly sensitive to the chosen exchange-correlation functional.

Characterization of Pestalotiopsis sp. causing gray leaf spot in coconut (Cocos nucifera L.) in Bangladesh.

Coconut (Cocos nucifera L.) is one of the most important fruit trees in Bangladesh. This tree is susceptible to various pathogens.

Dynamic Magnetic Resonance Imaging: An Aid To Preoperative-Planning Of Pelvic Organ Prolapse.

Background: Magnetic resonance imaging (MRI) has been commonly used in the assessment of preoperative pelvic organ prolapse to evaluate anatomical defects prior to surgery. This study aimed at evaluating the dynamic MRI reliability in the determination of pelvic organ prolapse and to assess its compliance with the physical examination for preoperative planning of women.

Methods: A prospective cross-sectional study was performed at the radiology department of the Jinnah Postgraduate Medical Centre Karachi from April-October 2019.

Association study of six candidate genes with major depressive disorder in the North-Western population of Pakistan.

People around the world are currently affected by Major Depressive Disorder (MDD). Despite its many aspects, symptoms, manifestations and impacts, efforts have been made to identify the root causes of the disorder. In particular, genetic studies have concentrated on identifying candidate genes for MDD and exploring associations between these genes and some specific group of individuals.

Scope and cost-effectiveness of fermented corn straw roughage-based buffalo fattening approach.

Objective: This experiment was undertaken to assess the scope and cost-effectiveness of the fermented corn mixture (FCM)-based buffalo fattening approach compared to urea molasses straw (UMS) and silage-based approach.

Materials And Methods: A completely comparative randomized design experiment was conducted for 90 days with three treatments and five buffalo bulls in each. UMS, silage, and FCM roughage-based fattening diets were attributed as T, T, and T, respectively.

Effect of Rot-, Fire-, and Water-Retardant Treatments on Jute Fiber and Their Associated Thermoplastic Composites: A Study by FTIR.

Natural renewable materials can play a big role in reducing the consumption of synthetic materials for environmental sustainability. Natural fiber-reinforced composites have attracted significant research and commercial importance due to their versatile characteristics and multi-dimensional applications. As the natural materials are easily rotten, flammable, and moisture absorbent, they require additional chemical modification for use in sustainable product development.

Environmental kuznets curve and causal links between environmental degradation and selected socioeconomic indicators in Bangladesh.

This study has investigated the Environmental Kuznets Curve (EKC) hypothesis and focuses on the resource stock of the country in relation to the selection of environmental degradation indicators. Acknowledging the critical role of the EKC for policy formulation and development strategies, this study has examined the validity of the EKC hypothesis by exploring the relationship between economic growth, urbanization, energy consumption, trade openness, human capital and ecological footprints for the period 1972-2018 in Bangladesh. The autoregressive distributive lag bounds testing approach is applied for this purpose, taking into account the structural break in the time series.

Direct reprogramming induces vascular regeneration post muscle ischemic injury.

Reprogramming non-cardiomyocytes (non-CMs) into cardiomyocyte (CM)-like cells is a promising strategy for cardiac regeneration in conditions such as ischemic heart disease. Here, we used a modified mRNA (modRNA) gene delivery platform to deliver a cocktail, termed 7G-modRNA, of four cardiac-reprogramming genes-Gata4 (G), Mef2c (M), Tbx5 (T), and Hand2 (H)-together with three reprogramming-helper genes-dominant-negative (DN)-TGFβ, DN-Wnt8a, and acid ceramidase (AC)-to induce CM-like cells. We showed that 7G-modRNA reprogrammed 57% of CM-like cells in vitro.

The Current Situation Regarding Long-Acting Insulin Analogues Including Biosimilars Among African, Asian, European, and South American Countries; Findings and Implications for the Future.

Diabetes mellitus rates continue to rise, which coupled with increasing costs of associated complications has appreciably increased global expenditure in recent years. The risk of complications are enhanced by poor glycaemic control including hypoglycaemia. Long-acting insulin analogues were developed to reduce hypoglycaemia and improve adherence.

Correlation between Length of Ala and Transverse Diameter of First Sacral Vertebral Body in both Sexes.

Sacrum is a triangular bone formed by the fusion of five sacral vertebrae. It is situated near the lower end of the spinal column, where it joins both hip bones to form the posterio superior wall of the pelvic cavity. It is an important bone for identification of sex in human skeletal system.

Prevalence of polypharmacy and associated adverse health outcomes in adult patients with chronic kidney disease: protocol for a systematic review and meta-analysis.

Background: Polypharmacy, often defined as the concomitant use of ≥ 5 medications, has been identified as a significant global public health threat. Aging and multimorbidity are key drivers of polypharmacy and have been linked to a broad range of adverse health outcomes and mortality. Patients with chronic kidney disease (CKD) are particularly at high risk of polypharmacy and use of potentially inappropriate medications given the numerous risk factors and complications associated with CKD.

Association between body mass index, dosing strategy, and efficacy of immune checkpoint inhibitors.

Background: Increased body mass index (BMI) has been associated with improved response to immune checkpoint inhibitors (ICIs) in multiple cancer types. We evaluated associations between BMI, ICI dosing strategy, and clinical outcomes.

Methods: We abstracted clinical data on patients with cancer treated with ICI, including age, sex, cancer type, BMI, ICI type, dosing strategy (weight-based or fixed), radiographic response, overall survival (OS), and progression-free survival (PFS).

Sleep Problems in Children with Autism Spectrum Disorder in Bangladesh: A Case-Control Study.

Background: Sleep problems in children with Autism Spectrum Disorder (ASD) are highly prevalent, but little information is available on this issue in low- to middle-income countries (LMIC) such as Bangladesh. Therefore, the present study investigated the prevalence and socio-demographic determinants of ASD sleep disturbances in a comparison with typically developing children (TDC).

Methods: A cross-sectional interview study was carried out within a total of 446 Bangladeshi mothers, whose children's mean age was 8.

An mRNA-based vaccine candidate against SARS-CoV-2 elicits stable immuno-response with single dose.

D614G genotype of SARS-CoV-2 virus is highly infectious and responsible for almost all infection for 2nd wave. However, there are currently no reports with D614G as vaccine candidate. Here we report the development of an mRNA-LNP vaccine with D614G variant and characterization in animal model.

Cyberknife Radiosurgery in Hepatocellular Carcinoma.

Objective: To determine the outcome of Stereotactic Body Radiation Therapy (SBRT) and its prognostic factors among hepatocellular carcinoma (HCC) patients.

Study Design: Descriptive study.

Place And Duration Of Study: Department of Radiology and Cyberknife Robotic Radiosurgery, Jinnah Postgraduate Medical Centre (JPMC), Karachi, Pakistan from 1st July 2019 to 31st August 2020.

Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart.

Heart failure (HF) remains a major cause of morbidity and mortality worldwide. One of the risk factors for HF is cardiac hypertrophy (CH), which is frequently accompanied by cardiac fibrosis (CF). CH and CF are controlled by master regulators mTORC1 and TGF-, respectively.

Determinants of nutrition knowledge, attitude and practices of adolescent sports trainee: A cross-sectional study in Bangladesh.

Background: Nutrition is an important predictor of an athlete's performance. It is more important for particularly those athletes who are in the growing stage (adolescents). This study aimed to assess their current level of knowledge, attitude, and practices (KAP) of nutrition and to predict potential factors impacting their level of these KAP.

Functional Dyspepsia, Peptic Ulcer, and Helicobacter pylori Infection in a Rural Community of South Asia: An Endoscopy-Assisted Household Survey.

Introduction: Functional dyspepsia (FD), although commoner than organic dyspepsia (OD) in-hospital studies, community data, particularly from rural areas, are lacking. We performed a rural community study in Bangladesh with the primary aims to evaluate (i) the prevalence of uninvestigated dyspepsia (UD), FD, and OD and (ii) the risk factors for UD.

Methods: This house-to-house survey was performed using a translated-validated enhanced Asian Rome III questionnaire and endoscopy with Helicobacter pylori tests, including genotyping.

Electrochemical Sensing Platforms of Dihydroxybenzene: Part 2 - Nanomaterials Excluding Carbon Nanotubes and Graphene.

The high surface-to-volume ratio and desirable chemical, thermal, and catalytic properties of nanomaterials have made them promising electrode materials for sensing applications. As such, different nanomaterials and their nanocomposite-based individual and/or simultaneous detection of dihydroxybenzene (DHB) have been reported in recent years. Due to the low degradation rate and high toxicity of DHB isomers, the development of innovative and robust sensors for their simultaneous detection has received considerable attention.

Metabolic phenotyping of opioid and psychostimulant addiction: A novel approach for biomarker discovery and biochemical understanding of the disorder.

Despite the progress in characterising the pharmacological profile of drugs of abuse, their precise biochemical impact remains unclear. The metabolome reflects the multifaceted biochemical processes occurring within a biological system. This includes those encoded in the genome but also those arising from environmental/exogenous exposures and interactions between the two.

Predicting sun protection measures against skin diseases using machine learning approaches.

Background: The substantial growth rate of skin cancer has necessitated adequate protection from solar radiation. Consequently, analyzing sun protection practices is an imperative research area in dermatology and pharmacology.

Aims: This paper aims to analyze public sun-protection manners in the Arabian Peninsula regions.

Electrochemical Sensing Platforms of Dihydroxybenzene: Part 1 - Carbon Nanotubes, Graphene, and their Derivatives.

Dihydroxybenzene is regarded as a serious environmental pollutant. Its detection through electrochemical methods is still challenging due to having a similar structure and overlapping signals with the conventional bare electrode. Thanks to the unique features and wide applicability of carbon nanotubes, graphene, and their derivatives, they can be used as modifiers to overcome the poor resolution ability of bare electrodes in the detection of dihydroxybenzene.

Ongoing efforts to improve the management of patients with diabetes in Bangladesh and the implications.

Background: Prevalence rates of patients with diabetes are growing across countries, and Bangladesh is no exception. Associated costs are also increasing, driven by costs associated with the complications of diabetes including hypoglycemia. Long-acting insulin analogues were developed to reduce hypoglycemia as well as improve patient comfort and adherence.

Evaluation of biological and chemical additives on microbial community, fermentation characteristics, aerobic stability, and in vitro gas production of SuMu No. 2 elephant grass.

Background: The study was conducted to evaluate the effects of biological and chemical additives on microbial community, fermentation characteristics, aerobic stability, and in vitro gas production of SuMu No. 2 elephant grass.

Results: Aerobic bacteria and yeast were not affected on days 5 and 7 but were significantly (P < 0.