Publications by authors named "Sulistiawati Sulistiawati"
Article Synopsis
- Prolonged exposure to UV radiation can damage skin, leading to collagen breakdown and reduced enzyme activity, contributing to photoaging.
- Fucoidan (FUC) has promising antiaging benefits, like promoting collagen production and inhibiting enzyme activity, but its large molecular size makes it difficult to penetrate skin when applied topically.
- A new delivery system combining thermoresponsive gel (TRG) with solid microneedles (SMNs) effectively enhances FUC's skin absorption, showing significant antiaging effects in tests on rats after UV exposure.
Declined cognitive function is commonly complained during the menopausal transition and continues afterward. Combining different exercises potentially leads to greater improvements in cognitive function, however, evidence of the benefits that accrue with multicomponent exercise training, specifically for postmenopausal women is limited. Therefore, this study aimed to investigate the effects of short-term multicomponent exercise training programs on executive function in postmenopausal women.
View Article and Find Full Text PDFDevelopment of itraconazole ocular delivery system using β-cyclodextrin complexation incorporated into dissolving microneedles for potential improvement treatment of fungal keratitis.
J Biomater Sci Polym Ed
October 2024
Article Synopsis
- * Researchers created an inclusion complex (ITZ-IC) using β-cyclodextrin (β-CD), which significantly increased ITZ's solubility by 4-fold and confirmed stable binding through molecular docking studies.
- * A dissolving microneedle (DMN) system was developed for ocular delivery of ITZ-IC, showing good mechanical properties, rapid dissolution, 75.71% permeation through corneas, and no irritation, indicating a safe and effective delivery method.
Article Synopsis
- Sildenafil citrate (SIL) is a common treatment for erectile dysfunction but has poor solubility and bioavailability, making it less effective when taken orally.
- This study presents a new transdermal delivery system using hydrogel-forming microneedles and a tablet reservoir to enhance SIL delivery through the skin.
- In vivo tests showed that this innovative method significantly increased the drug's effectiveness and bioavailability compared to traditional oral forms, suggesting a safer and more efficient treatment option for erectile dysfunction.
Application of Biomaterials in the Development of Hydrogel-Forming Microneedles Integrated with a Cyclodextrin Drug Reservoir for Improved Pharmacokinetic Profiles of Telmisartan.
ACS Biomater Sci Eng
March 2024
Article Synopsis
- * The study developed a novel hydrogel-forming microneedle system combined with a tablet-like reservoir (HFMN-DCT) to enhance the transdermal delivery of TEL, utilizing materials like PVP, PVA, and tartaric acid.
- * Results showed that the new system improved the solubility and release of TEL significantly, demonstrated good mechanical properties, did not cause skin irritation, and performed well in both lab studies and tests on rats, indicating its potential for effective transdermal drug delivery.
Development of probiotic loaded multilayer microcapsules incorporated into dissolving microneedles for potential improvement treatment of vulvovaginal candidiasis: A proof of concept study.
J Colloid Interface Sci
October 2023
Article Synopsis
- Vulvovaginal candidiasis (VVC) is a vaginal infection caused by an overgrowth of Candida species, particularly Candida albicans, and is marked by a change in the normal vaginal microbiota, where Lactobacillus plays an important protective role.
- Studies show that Candida species are developing resistance to azole drugs commonly used to treat VVC, prompting the exploration of L. plantarum, a probiotic, as a potential treatment alternative.
- The study successfully created a vaginal drug delivery system using dissolving microneedles (DMNs) that release L. plantarum-loaded microcapsules, demonstrating improved efficacy in inhibiting Candida albicans growth while being non-irritating and safe for the vaginal mucosa
Globally, the increase of pathogenic bacteria with antibiotic-resistant characteristics has become a critical challenge in medical treatment. The misuse of conventional antibiotics to treat an infectious disease often results in increased resistance and a scarcity of effective antimicrobials to be used in the future against the organisms. Here, we discuss the rise of antimicrobial resistance (AMR) and the need to combat it through the discovery of new synthetic or naturally occurring antibacterial compounds, as well as insights into the application of various drug delivery approaches delivered via various routes compared to conventional delivery systems.
View Article and Find Full Text PDFDevelopment of Solid Lipid Nanoparticle-Loaded Polymeric Hydrogels Containing Antioxidant and Photoprotective Bioactive Compounds of Safflower ( L.) for Improved Skin Delivery.
Langmuir
February 2023
Safflower ( L.) is a potent natural antioxidant because of active compounds such as quercetin (QU) and luteolin (LU). These components prevent damage to the skin caused by free radicals from UV rays.
View Article and Find Full Text PDFAs an effective anti-HIV drug, cabotegravir (CAB) is currently administered via oral and injection routes, leading to several drawbacks, such as poor oral bioavailability and problems in the injection application process, as well as low drug concentration in vaginal tissue of woman patients. To overcome these issues, for the first time, we formulated CAB into three types of vaginal gels, considering the benefits of vaginal tissue as a delivery route. Thermosensitive gel, mucoadhesive gel, and the combination of these gels were developed as suitable carriers for CAB.
View Article and Find Full Text PDFDeterminants of Tobacco Smoking Addiction in Rural Indonesian Communities.
J Environ Public Health
November 2020
Purpose: To analyze the determinants of tobacco smoking addiction in rural areas.
Methods: A cross-sectional study was conducted on February 2020. The self-administered questionnaire ( = 0.
Article Synopsis
- - The study examines how separating HIV patients from others in a hospital affects medical interns' adherence to standard precautions (SP) to prevent exposure to blood and body fluids.
- - Conducted in March 2017, the research involved 150 medical students using a questionnaire to assess their SP practices and attitudes while working in both HIV and non-HIV wards.
- - Results showed that students were more diligent in following SP protocols in the HIV ward, but this separation negatively influenced their overall adherence to SP in other wards.