Bioaccumulation of metals from nickel smelter waste in P and F1 generation of exposed animals. Part III. Morphological responses.

Inhalation exposure experiments were conducted on a group of female adult Chinchilla rabbits placed in a field biomonitoring station located downwind from dumped nickel refinery wastes. Their F1 generation offsprings were exposed prenatally and 6 weeks postnatally. After termination of exposure, both P and F1 generation rabbits were sacrificed, their organs removed and subjected to a histologic examination using light and electron microscopy techniques.

Biomonitoring of environmental pollution hazards from a nickel smelter waste dump.

Longterm field exposure study was carried out on 10 rabbits placed for 6 months in a bioindication station located about 3 km downwind of a disposal site of nickel smelter waste dump. As revealed by the method of atomic absorption spectrophotometry, all of these animals showed elevated nickel and chromium levels in their body organs and hair. These findings were paralleled by histologic abnormalities in the lungs and liver tissues.

Modulation of peripheral lymphocyte and alveolar macrophage activity by magnesite emissions.

Modulation of alveolar macrophage and peripheral lymphocyte activities in rats exposed to magnesite emissions was tested under field and laboratory conditions. The field exposure test were conducted in a locality near a magnesite ore processing plant, the time observation was 18 weeks. The laboratory exposure tests were performed in an inhalation chamber at a constant magnesite dust aerosol concentration of 50 mg .