Lutein Prevents Liver Injury and Intestinal Barrier Dysfunction in Rats Subjected to Chronic Alcohol Intake.

Chronic alcohol intake can affect both liver and intestinal barrier function. The goal of this investigation was to evaluate the function and mechanism of lutein administration on the chronic ethanol-induced liver and intestinal barrier damage in rats. During the 14-week experimental cycle, seventy rats were randomly divided into seven groups, with 10 rats in each group: a normal control group (Co), a control group of lutein interventions (24 mg/kg/day), an ethanol model group (Et, 8-12 mL/kg/day of 56% (v/v) ethanol), three intervention groups with lutein (12, 24 and 48 mg/kg/day) and a positive control group (DG).

Lutein Can Alleviate Oxidative Stress, Inflammation, and Apoptosis Induced by Excessive Alcohol to Ameliorate Reproductive Damage in Male Rats.

Chronic excessive alcohol intake may lead to male reproductive damage. Lutein is a carotenoid compound with antioxidant activity. The purpose of this study was to observe the effect of lutein supplementation on male reproductive damage caused by excessive alcohol intake.

Effect of different routes of administration on early cognitive function following inguinal hernia repair.

Purpose: To analyze the effects of different routes of dexmedetomidine administration on early cognitive function following inguinal hernia repair.

Methods: A total of 83 patients with pediatric inguinal hernias admitted to our hospital from January 2018 to October 2020 were divided into control group (CNG, n = 41) and observation group (OG, n = 42) by random number table. The OG was given 2 μg/kg of dexmedetomidine hydrochloride by intranasal administration, and the CNG was treated with 0.

The Impact of COVID-19 on Dentistry in Yichang, China, and Protective Suggestions for Normalisation of Epidemic Prevention.

Background: Coronavirus disease 2019 (COVID-19) has been identified as a pandemic by the World Health Organization in March 2020, and it affects all aspects of life, including dental care.

Objectives: The purpose of this article is to explore the impact of COVID-19 on the daily operations of the stomatology department and provide some guidance for dental health care personnel around the world in continuing to provide exemplary care while limiting the spread of COVID-19.

Materials And Methods: Retrospective analyses were performed on dental patients' medical records from the stomatology department of the First People's Hospital of Yichang, China, which were collected in the pre-epidemic, epidemic, and post-epidemic periods.

Analysis of anxiety-related factors amongst frontline dental staff during the COVID-19 pandemic in Yichang, China.

Background: Dental staff were characterized with the tolerance of enduring stress and they are at a high risk to respiratory infectious disease. This study compared the anxiety level of the frontline dental staff (FDS) to the general public in Yichang during the coronavirus disease of 2019 (COVID-19) pandemic and examined potential explanatory factors to the differences.

Methods: Two online questionnaires were used separately to collect data from FDS and the general public.

A Comparison of SCC Behaviors for Two States of FeGa Alloys in a 3.5 wt % NaCl Solution.

The new magnetostrictive material Fe-Ga alloy has drawn considerable attention due to its excellent performance. The microstructure of the Fe-Ga alloy, which varies with the state of preparation or processing, not only affects the magnetostriction but also the mechanical service stability, i.e.

Estimation of PM2.5 Concentrations in China Using a Spatial Back Propagation Neural Network.

Methods for estimating the spatial distribution of PM concentrations have been developed but have not yet been able to effectively include spatial correlation. We report on the development of a spatial back-propagation neural network (S-BPNN) model designed specifically to make such correlations implicit by incorporating a spatial lag variable (SLV) as a virtual input variable. The S-BPNN fits the nonlinear relationship between ground-based air quality monitoring station measurements of PM, satellite observations of aerosol optical depth, meteorological synoptic conditions data and emissions data that include auxiliary geographical parameters such as land use, normalized difference vegetation index, elevation, and population density.

Clinical Efficacy Evaluation for Treating Trigeminal Neuralgia Using a Personalized Digital Guide Plate-Assisted Temperature-Controlled Radiofrequency.

The aim of this study was to explore the application and efficacy of personalized digital guiding plate-aided radiofrequency in treating trigeminal neuralgia (TN). A total of 117 cases (93 patients) of TN from January 2015 to December 2016 were divided into the study group (n = 53) and the traditional group (n = 64). Patients in the study group were treated by the radiofrequency through a personalized digital guiding plate, whereas those in the traditional group were treated by the traditional method.

An in-depth analysis identifies two new independent signals in 11q23.3 associated with vitiligo in the Chinese Han population.

Background: Vitiligo is an autoimmune disease, characterized by progressive loss of skin pigmentation, which is caused by the interactions of multiple factors, such as heredity, immunity and environment. Recently, a single nucleotide polymorphism (SNP) rs638893 at 11q23.3 region was identified as a risk factor for vitiligo in genome-wide association studies and multiple SNPs in this region have been associated with other autoimmune diseases.

Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease.

The human major histocompatibility complex (MHC) region has been shown to be associated with numerous diseases. However, it remains a challenge to pinpoint the causal variants for these associations because of the extreme complexity of the region. We thus sequenced the entire 5-Mb MHC region in 20,635 individuals of Han Chinese ancestry (10,689 controls and 9,946 patients with psoriasis) and constructed a Han-MHC database that includes both variants and HLA gene typing results of high accuracy.

Association analysis revealed one susceptibility locus for vitiligo with immune-related diseases in the Chinese Han population.

Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other immune-related diseases. However, there is no reported study on the associations between immune susceptibility polymorphisms and the risk of vitiligo with immune-related diseases. The aim of this study was to evaluate the potential influence of 10 single-nucleotide polymorphisms (SNPs) at 18q21.

[Study on the injury effect of ammonium perchlorate to lung].

Objective: To study the injury effect of ammonium perchlorate (AP) to lung and to explore whether AP can cause pulmonary fibrosis.

Methods: To detect the levels of cell counts, TNF-alpha, MDA, HYP and the synthesis of collagen in BALF or rat lung after a certain time when rats were injected AP by intratracheal instillation.

Results: AP could bring about acute lung damage and inflammatory reaction.

[Toxic effects of ammonium perchlorate on thyroid of rats].

Objective: To study the effects of toxicity of ammonium perchlorate (AP) on thyroid of rats.

Methods: Eighty-eight Wistar rats were treated orally with different dosages of AP. Three treated groups received 129, 257, 514 mg.