Is it worth implementing the Blue Sky Defense Battle initiative? A cost-benefit analysis of the Chengdu case.

To mitigate air pollution, China began implementing its Three-Year Action Plan for Winning the Blue Sky Defense Battle in 2018. The rapid decline in the annual average concentration of particulate matter PM2.5 raised the authors' interest in the cost efficiency of the implementation of the action plan.

Structural design and mechanical performance evaluation of personalized irregular porous L3-L4 fusion cage by additive manufacturing.

With the advent of additive manufacturing, it has become feasible to fabricate personalized porous fusion cages for biomedical applications. This study aims to ensure a suitable range of pore sizes for bone tissue and cell growth, investigate the biomechanical properties of irregular porous fusion cages at different target pore sizes, determine optimal structural parameters, and evaluate their mechanical properties. In this study, TC4 irregular porous fusion cages with varying target apertures were designed using the Voronoi method for the L3-L4 intervertebral space of the lumbar spine.

[Clinical features and genetic analysis of three patients with Infantile liver failure syndrome type 2 due to variants of NBAS gene].

Objective: To explore the clinical features and genetic characteristics of three patients with Infantile liver failure syndrome type 2 (ILFS2).

Methods: Three children who were diagnosed with ILFS2 at the Children's Hospital Affiliated to Zhengzhou University from February 2023 to February 2024 were selected as the study subjects. Clinical data of the children were collected.

Defects of WFS1-mediated peptide hormones secretion contribute to the manifestations of Wolfram syndrome.

Aims: The study aims to investigate whether WFS1 is involved in the regulation of the exportation and secretion of other peptide hormones, as well as to elucidate the precise molecular mechanisms underlying WS caused by pathogenic mutations in the WFS1 gene.

Materials And Methods: The plasma proteome from the WS patients (n = 2, male) and WFS1-deficient mice (n = 5, male) were analyzed using liquid-chromatography tandem mass spectrometry (LC-MS/MS), while age- and gender-matched healthy individuals and wildtype (WT) mice serve as controls. WFS1-deficient mice were intraperitoneally injected with IGF1 starting from 4 weeks of age.

S-Doped Hollow Multi-Metallic Prussian Blue Analogue (PBA) Nanoplatform for Enhanced Anticancer for Cervical Cancer.

Purpose: Developing novel multimodal nanomaterials-based anticancer agents to meet complex clinical demands is an urgent challenge. This study presents a novel uniform hollow S-doped NiCuFe Prussian blue analogue (NiCuFe-S) with satisfactory size and properties as anticancer agents for efficient cervical cancer therapy using a simple and environmentally friendly procedure.

Methods: The formation mechanism and the reason for enhanced performance of NiCuFe-S were characterized and discussed by diverse spectroscopic and microscopic methods.

[Optimization Design of Interbody Fusion Cage withDifferent Bone Densities Printed in 3D].

Based on the original data of cervical spine, the models of cervical C6 and C7 segments were reconstructed through medical image processing and reverse modeling operations, then the models were assembled to obtain the basic data of interbody fusion cage. According to the basic data, the structures of rectangular porous, gradient porous and octahedral porous interbody fusion cages were established respectively. Maximum force on the adult male neck was applied to the fusion device, and the stress, strain and maximum deformation of the fusion device were solved by finite element analysis.

[Genetic and clinical analysis of a child with Shwachman-Diamond syndrome due to compound heterozygous variants of SBDS gene].

Objective: To analyze the clinical features and genetic characteristics of a patient with Shwachman-Diamond syndrome (SDS) due to compound heterozygous variants of SBDS gene.

Methods: A female child with SDS who was admitted to the Children's Hospital Affiliated to Zhengzhou University in February 2022 was selected as the study subject. Clinical data of the child was collected.

Wolfram syndrome type 1: a case series.

Background: Wolfram syndrome (WS) is a rare autosomal recessive multisystem neurodegenerative disease characterized by non-autoimmune insulin-dependent diabetes mellitus, optic atrophy, sensorineural deafness, and diabetes as the main features. Owing to clinical phenotypic heterogeneity, the misdiagnosis rate is high. However, early accurate diagnosis and comprehensive management are key to improving quality of life and prolonging life.

Decoding the effect of demographic factors on environmental health based on city-level PM pollution in China.

Although considerable health effects are gained from air quality improvement action plans implemented in China recently, they may have been amplified or offset due to the complexity and uncertainty of the changing demographic factors. In this study, we developed a framework for analyzing the effects of demographic factors on environmental health effects, focusing on three aspects: population scale, age structure, and spatial distribution. We quantified the above three effects by investigating how the health endpoint changed by the three demographic factors, based on a strategy of counterfactual and step-by-step relaxing hypothesis.

Pathogenicity of Congenital Adrenal Hyperplasia Induced by the p.P377L Mutation of CYP11B1.

CYP11B1 encodes an 11β-hydroxylase that is involved in the catalysis of adrenal glucocorticoids and the production of cortisol. Mutations in CYP11B1 can result in congenital adrenal hyperplasia. We discovered a proband with a CYP11B1 gene mutation.

Integrated flow cytometric and proteomics analyses reveal the regulatory network underlying sugarcane protoplast responses to fusion.

Background: Somatic cell fusion is a process that transfers cytoplasmic and nuclear genes to create new germplasm resources. But our limited understanding of the physiological and molecular mechanisms that shape protoplast responses to fusion.

Method: We employed flow cytometry, cytology, proteomics, and gene expression analysis to examine the sugarcane (Saccharum spp.

A diabetes prediction model based on Boruta feature selection and ensemble learning.

Background And Objective: As a common chronic disease, diabetes is called the "second killer" among modern diseases. Currently, there is no medical cure for diabetes. We can only rely on medication for auxiliary treatment.

Nitidine chloride regulates cell function of bladder cancer in vitro through downregulating Lymphocyte antigen 75.

Nitidine chloride (NC) is effective on cancer in many tumors, but its effect on bladder cancer (BC) is unknown. We conducted cell function experiments to verify the antineoplastic effect of NC on BC cell lines (5637, T24, and UM-UC-3) in vitro. Then, mRNAs of NC-treated and NC-untreated BC cells were extracted for mRNA sequencing.

Study on the Process Characteristics Based on Joule Heat of Sliding-Pressure Additive Manufacturing.

This study developed an experimental system based on Joule heat of sliding-pressure additive manufacturing (SP-JHAM), and Joule heat was used for the first time to accomplish high-quality single-layer printing. The roller wire substrate is short-circuited, and Joule heat is generated to melt the wire when the current passes through. Through the self-lapping experimental platform, single-factor experiments were designed to study the effects of power supply current, electrode pressure, contact length on the surface morphology and cross-section geometric characteristics of the single-pass printing layer.

Establishment and validation of a nomogram for predicting immune-related prognostic features in trunk melanoma-specific death.

Background: Trunk melanoma is one of the most common and deadly types of melanomas. Multiple factors are associated with the prognosis of patients with trunk melanoma. Currently, direct, and reliable clinical tools for early assessment of individual specific risk of death are limited, and most of them are prediction models for all-cause death.

Insulin-like growth factor-1 levels are associated with interventricular septal thickening.

Background And Objective: Insulin-like growth factor-1 (IGF-1) regulates cardiomyocyte survival, hypertrophy, and ageing. We aimed to investigate the potential correlation between IGF-1 and interventricular septal (IVS) thickening.

Methods: Medical record data were obtained from patients hospitalized between May 1, 2012 and April 30, 2022.

Distinguish the Value of the Benign Nevus and Melanomas Using Machine Learning: A Meta-Analysis and Systematic Review.

Background: Melanomas, the most common human malignancy, are primarily diagnosed visually, beginning with an initial clinical screening and followed potentially by dermoscopic analysis, a biopsy, and histopathological examination. We aimed to systematically review the performance and quality of machine learning-based methods in distinguishing melanoma and benign nevus in the relevant literature.

Method: Four databases (Web of Science, PubMed, Embase, and the Cochrane library) were searched to retrieve the relevant studies published until March 26, 2022.

Metabarcoding and Metabolome Analyses Reveal Mechanisms of Growth Promotion by Fairy Ring of .

Fairy rings are a unique ecological phenomenon caused by the growth of the fungal mycelium in the soil. Fairy rings formed by (LM) are generally distributed in the Mongolian Plateau, where they promote plant growth without fertilization and alleviate fertilizer use. We previously investigated the soil factors regulating growth promotion in a fairy ring ecosystem; however, the aspects of the plant (, LC) that promote growth have not been explored.

Serum pharmacochemistry and pharmacokinetics of major components after oral administration of Luhong recipe in rats using ultra-performance liquid chromatography-tandem mass spectrometry.

Luhong recipe (LHR) is has been used as an empirical prescription for treating chronic heart failure for long, with safety, reliability, and significant efficacy. However, its pharmacokinetics has not yet been studied. This study aims to establish a ultra performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous analysis of epimedin A, epimedin B, epimedin C, icariin, psoralen, and isopsoralen in rat plasma and apply it to the pharmacokinetic study of LHR after oral administration.

Transcriptome Analysis of Sugarcane Young Leaves and Protoplasts after Enzymatic Digestion.

Sugarcane somatic cell hybridization can break through the barrier of genetic incompatibility between distantly related species in traditional breeding. However, the molecular mechanisms of sugarcane protoplast regeneration and the conditions for protoplast preparation remain largely unknown. In this study, young sugarcane (ROC22) leaves were enzymatically digested, and the viability of protoplasts reached more than 90% after enzymatic digestion (Enzymatic combination: 2% cellulase + 0.

The antinociceptive and anti-inflammatory potential and pharmacokinetic study of significant alkamides ingredients from Asarum Linn.

Ethnopharmacological Relevance: Asari Radix et Rhizoma (ARR), including 3 major plants of genus Asarum Linn, A. heterotropoides Fr. Schmidt var.

Ang-(1-7) protects skeletal muscle function in aged mice.

Background: The angiotensin-converting enzyme 2 (ACE2)/angiotensin 1-7 (Ang-(1-7)) axis has been shown to protect against the age-associated decline in skeletal muscle function. Here, we investigated the protective effects of ACE2 in mitigating the age-associated decline of skeletal muscle function and to identify the potential underlying molecular mechanisms.

Methods: We measured the expression levels of Ang-(1-7) in C57BL/6J mice of different ages and correlated these levels with measures of skeletal muscle function.

Effects of different nutritional conditions on accumulation and distribution of Cr in Coix lacryma-jobi L. in Cr-contaminated constructed wetland.

In this research, micro Coix lacryma-jobi L. vertical flow constructed wetlands (VFCWs) were set up using domestic sewage (DWS) and 1/2 Hoagland nutrient solution (HNS) as VFCWs water sources. 0, 20 mg L and 40 mg L of Cr (in the form of KCrO) were added into the water sources separately in order to study the response of Coix lacryma-jobi L.