Molecular Docking Analysis of Siddha Formulation Parangipattai Chooranam Against Vaginal Candidiasis.

Vulvovaginal candidiasis called by its name Vellai Noi as per Siddha terminology is considerably the second most common cause of vaginal inflammation in the women of middle-aged group. Candida albicans are prioritised top among other pathogens in mediating vaginal inflammation and its related symptoms. Candida albicans exerts its virulence by secreting the enzyme known as secreted aspartyl proteinases (SAP) which allows hassle-free adherence and growth of the opportunistic pathogen.

Translation and validation of oral health impact profile-14 questionnaire into Indian sign language for hearing-impaired individuals.

Objectives: To translate and cross-culturally adapt the oral health impact profile-14 (OHIP-14) questionnaire into Indian sign language (ISL) using a video format and to evaluate its psychometric properties.

Methods: The study was conducted among hearing-impaired individuals attending the National Institute of Speech and Hearing, Thiruvananthapuram, Kerala. The OHIP-14 was translated to ISL in a video format.

Loss of dendritic connectivity in CA1, CA2, and CA3 neurons in hippocampus in rat under aluminum toxicity: antidotal effect of pyridoxine.

Aluminum chloride (AlCl(3); 4 mg/kg) was injected into the cerebrospinal fluid of adult rats as a one time dose. Rapid Golgi stained sections of hippocampus were examined for detailed histology of neurons in CA1, CA2, and CA3 areas. The axonal length and number of dendritic branches were seen reduced 30 days later in aluminum (Al)-injected group when compared to vehicle-injected controls.