Sesquiterpene Coumarins, Chromones, and Acetophenone Derivatives with Selective Cytotoxicities from the Roots of M. Bieb. (Apiaceae).

In search of selective cytotoxic compounds from species as potential leads for the treatment of various cancer diseases, a bioactivity-guided isolation study was performed on the roots of M. Bieb. COLO 205 (colon), K-562 (leukemia), and MCF-7 (breast) cancer cell lines were used to monitor the cytotoxic activity of column fractions and determine the IC value of the active compounds.

Sesquiterpene Coumarin Ethers with Selective Cytotoxic Activities from the Roots of Peşmen (Apiaceae) and Unequivocal Determination of the Absolute Stereochemistry of Samarcandin.

Ancient physicians frequently used the resin of species to treat cancer. Today, some folkloric recipes used for cancer treatment also contain the resin of species. The dichloromethane extract of the roots of exhibited cytotoxic activities against COLO 205 (colon), K-562 (lymphoblast), and MCF-7 (breast) cancer cell lines (IC = 52 µg/mL, 72 µg/mL, and 20 µg/mL, respectively).