Publications by authors named "Sulan Yan"

Aims: Acute myocarditis (AM) has been recognized as a rare complication of coronavirus disease 2019 (COVID-19) infection. This study was conducted to present the clinical characteristics, disease courses and short-term prognoses of Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induced AM in China, which has been unavailable so far.

Methods And Results: Data from 28 patients diagnosed with definite COVID-19-associated AM from 6 hospitals in China between 1 December 2022 and 30 June 2023 were collected and analysed.

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Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) are reported to cause stress cardiomyopathy (SC). This study evaluated the association between SSRI/SNRI use and the occurrence of cardiomyopathy in the publicly available U.S.

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Background: Clopidogrel is widely used to prevent and treat cardiovascular atherosclerosis and thrombosis. However, disturbance in the expression and activity of liver cytochrome metabolic enzymes significantly changes clopidogrel efficacy. Therefore, the effect of chronic unpredictable mild stress (CUMS)-induced depression on the expression of liver cytochrome metabolic enzymes and clopidogrel pharmacokinetics in rats were explored.

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Resveratrol (RES) protects myocardial cells from hypoxia/reoxygenation (H/R)-caused injury. However, the mechanism of this effect has not been clarified. Thus, in this study, we aimed to determine whether RES attenuates H/R-induced cell necroptosis by inhibiting the tumor necrosis factor-alpha (TNF-α)/receptor-interacting protein kinase 1 (RIP1)/RIP3/mixed-lineage kinase domain-like (MLKL) signaling pathway.

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Article Synopsis
  • MicroRNAs (like miR-520d) help control cell processes and can be important in heart problems like atrial fibrillation (AF).
  • The study found that when heart cells are stimulated quickly, a protein called ADAM10 increases while miR-520d decreases, which affects cell health.
  • Boosting miR-520d or reducing ADAM10 helps heart cells live better and reduces cell death in this rapid-pacing scenario.
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Dexmedetomidine (Dex), a sedative and analgesic agent, is known to have a cardioprotective effect against ischaemia/reperfusion (I/R) injury regulation of antioxidant and anti-inflammatory signals. In contrast, Se shows a cardioprotective effect against I/R injury, because it is a key component of selenoproteins, most of which are antioxidant enzymes such as GPxs and TrxRs. This study aimed to determine whether the protective effects on myocardial cells against I/R injury were further improved when treatment with Dex and Se in combination.

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Background: Prostaglandin-E1 (PGE1) is a potent vasodilator with anti-inflammatory and antiplatelet effects. However, the mechanism by which PGE1 contributes to the amelioration of cardiac injury remains unclear.

Methods: The present study was designed to investigate how PGE1 protects against hypoxia/reoxygenation (H/R)-induced injuries by regulating microRNA-21-5p (miR-21-5p) and fas ligand (FASLG).

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Background: Several heart failure (HF) risk models exist, however, most of them perform poorly when applied to real-world situations. This study aimed to develop a convenient and efficient risk model to identify patients with high readmission risk within 90 days of HF.

Methods: A multivariate logistic regression model was used to predict the risk of 90-day readmission.

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Synopsis of recent research by authors named "Sulan Yan"

  • - Sulan Yan's recent research predominantly focuses on cardiovascular complications associated with stress and infection, particularly the cardiovascular effects of COVID-19 and the implications of antidepressant use on heart health.
  • - Notable studies include a comprehensive analysis of COVID-19-associated acute myocarditis in China and an examination of the risks of stress cardiomyopathy linked to selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs).
  • - Additionally, Yan has explored the pharmacokinetics of clopidogrel in the context of chronic stress-induced depression and investigated various cardioprotective mechanisms, such as those involving resveratrol and protective microRNAs in myocardial injury settings.

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