Cytotoxic Evaluation, Molecular Docking, Molecular Dynamics, and ADMET Prediction of Isolupalbigenin Isolated from (Hassk). Merr. (Fabaceae) Stem Bark: Unveiling Its Anticancer Efficacy.

Introduction: , a medical plant found in sub-Saharan Africa and the Western Ghats of India, shows promise as a potential source of bioactive compounds to treat cancer. In our ongoing research on folk medical plants, we report the isolation of flavonoid compound from the stem bark of along with its cytotoxic activity against breast cancer (MCF-7 and T47D), and cervical cancer (HeLa) cell lines.

Purpose: This study aimed to isolate secondary metabolite from the stem bark of and evaluate its cytotoxic activity to support the use of folk medicinal plants as alternative therapy against cancer.

The Potential of Chicken-Herb Essence to Improve Milk Production and Infant Health in the Sprague Dawley Animal Model.

Breast milk serves as the primary source of nourishment for newborns. In cases of low milk production, one approach to address this challenge involves the consumption of lactagogues. Chicken-herb essence, a beverage rich in protein, amino acids, and minerals, presents itself as a viable option to supplement a lactating mother's diet, particularly in terms of protein intake.

S,N-GQD sensitization effect on the improvement of ZnO nanopencil photoelectrochemical properties.

ZnO photoanodes in photoelectrochemical (PEC) water splitting for green-hydrogen production are limited due to the large bandgap that is only confined to UV light. One of the strategies for broadening the photo absorption range and improving light harvesting is to modify a one-dimensional (1D) nanostructure to a three-dimensional (3D) ZnO superstructure coupling with a narrow-bandgap material, in this case, a graphene quantum dot photosensitizer. Herein, we studied the effect of sulfur and nitrogen co-doped graphene quantum dot (S,N-GQD) sensitization on the surface of ZnO nanopencil (ZnO NPc) to give a photoanode in the visible light spectrum.

3D-ZnO Superstructure Decorated with Carbon-Based Material for Efficient Photoelectrochemical Water-Splitting under Visible-Light Irradiation.

The depletion of fossil fuels is a worldwide problem that has led to the discovery of alternative energy sources. Solar energy is the focus of numerous studies due to its huge potential power and environmentally friendly nature. Furthermore, one such area of study is the production of hydrogen energy by engaging photocatalysts using the photoelectrochemical (PEC) method.

Isoflavone and Antioxidant of Instant Cream Soup Made from Pumpkin and Tempeh and Their Active Compound in Ovariohysterectomy Rat-Induced Alzheimer's Disease.

Menopause period associated with brain function disorders can caused by decreasing estradiol levels and increasing oxidative stress in the body. Antioxidant agents are required to balance oxidative stress in the body. Instant cream soup made from pumpkin and tempeh is a supplementary food containing isoflavone and antioxidant agents.

Nutritional Content and Characteristics of Pumpkin Cream Soup with Tempeh Addition as Supplementary Food for Elderly.

An increase in the number of elderly people indicates a higher life expectancy. However, this is also a new challenge since the elderly tends to have age-related diseases, thus the physical, psychological, and sensory disorders that will affect their nutritional status. The development of geriatric foods such as cream soup made from pumpkin and tempeh is considered to be the solution to prevent this situation.

Synergistic effect of vascular endothelial growth factor gene inactivation in endothelial cells and skeletal myofibres on muscle enzyme activity, capillary supply and endurance exercise in mice.

New Findings: What is the central question of this study? Does vascular endothelial growth factor (VEGF) expressed by both endothelial cells and skeletal myofibres maintain the number of skeletal muscle capillaries and regulate endurance exercise? What is the main finding and its importance? VEGF expressed by both endothelial cells and skeletal myofibres is not essential for maintaining capillary number but does contribute to exercise performance.

Abstract: Many chronic diseases lead to exercise intolerance, with loss of skeletal muscle capillaries. While many muscle cell types (myofibres, satellite cells, endothelial cells, macrophages and fibroblasts) express vascular endothelial growth factor (VEGF), most muscle VEGF is stored in myofibre vesicles which can release VEGF to signal VEGF receptor-expressing cells.

A biorefinery strategy for spent industrial ginger waste.

An integrated biorefinery approach using spent industrial ginger waste for resource recovery is reported. Valuable products including ginger oil, starch, microfibrillated cellulose (MFC), bio-oil and hydrochar were obtained. Approximately 4 % ginger oil, with a profile similar to commercial ginger oil, can be recovered via Soxhlet or Supercritical CO + 10 %EtOH extraction.

Tempe, Tofu, and Amyloid-β 1-40 Serum Levels in Ovariectomized Rats.

Background: Estrogens have been found to reduce amyloid-β (Aβ) levels, a risk factor associated with dementia. We hypothesized that phytoestrogenic soybean products such as tempe and tofu might show similar effects.

Objective: The aim of this study were to analyze the effect of tempe and tofu flour on Aβ1-40 serum levels in ovariectomized rats.

The effect of propolis administration on fetal development.

Propolis is one of the bee products that widely used in health therapy. However, there has no study evaluating the developmental toxicity of propolis. This study was aimed to analyze the effect of propolis administration during pregnancy on fetal development.

Intake of essential fatty acids in Indonesian children: secondary analysis of data from a nationally representative survey.

Essential fatty acids (EFA) such as α-linolenic acid (ALA) and linoleic acid (LA) are needed for healthy growth and development of children. Worldwide, reliable intake data of EFA are often lacking. The objective of this study was to investigate dietary intake of EFA in Indonesian children.

Tempereversed effects of ovariectomy on brain function in rats: Effects of age and type of soy product.

Backgroud: The aims of this study were to analyze the differences in nutrient content and isoflavones in tempe flour and tofu flour, and to analyze the effect of tempe and tofu flour on cognitive function of female rats after ovariectomy.

Method: Seventy two (72) white female Sprague Dawley strain rats, aged 12 months were used for this study. Before the intervention 52 rats underwent ovariectomy (OVx) and they were grouped into 4 intervention groups: tempe flour (Tp), tofu flour (Tf), estradiol (E2), and casein as a control protein (Cs).

Skeletal myofiber VEGF is necessary for myogenic and contractile adaptations to functional overload of the plantaris in adult mice.

The ability to enhance muscle size and function is important for overall health. In this study, skeletal myofiber vascular endothelial growth factor (VEGF) was hypothesized to regulate hypertrophy, capillarity, and contractile function in response to functional overload (FO). Adult myofiber-specific VEGF gene-ablated mice (skmVEGF(-/-)) and wild-type (WT) littermates underwent plantaris FO or sham surgery (SHAM).

Mongolian gerbils can utilize provitamin-A carotenoids in deep-fried carrot chips.

Deep-fried carrot chips, containing provitamin-A carotenes, were developed as an alternative mode of dietary intervention to combat vitamin A deficiency. The biological use of carotenoids in this product as vitamin A precursors was evaluated in Mongolian gerbils. Male 4-wk-old gerbils were fed a diet containing all essential nutrients for 1 wk.

Carotenoid content, physicochemical, and sensory qualities of deep-fried carrot chips as affected by dehydration/rehydration, antioxidant, and fermentation.

Carrot slices were subjected to one of the following experiments prior to deep-frying: (A) dehydration/rehydration, (B) soaking in different antioxidants, and (C) fermentation with/without blanching. There were no significant differences (P > or = 0.05) in carotenoid contents among carrot chips treated with/without dehydration.