Rapid framework for quantitative magnetization transfer imaging with interslice magnetization transfer and dictionary-driven fitting approaches.

Purpose: To develop a rapid framework for quantitative magnetization transfer (qMT) imaging based on the 2D interslice MT and dictionary-driven fitting approaches.

Methods: Sequential balanced steady-state free precession (bSSFP) scanning was performed on a whole human brain in a total of 12 conditions from six different interslice gaps and two different flip angles. To obtain qMT maps, the acquired 12 datasets were fitted to a dictionary predefined by using Bloch equation simulations based on the two-pool MT model.