Effect of Music Therapy on Quality of Life in Geriatric Population: A Systematic Review and Meta-Analysis.

The older population is susceptible to dementia, Alzheimer's and depression. A growing elderly population poses a burden on caregivers and society. If their cognitive and psychological health is maintained, they may not need to depend on others for their needs, thereby reducing the burden on caregivers.

Geriatric Oral Health and Quality of Life Among the Indigenous Irula Tribes of Tamil Nadu.

Objectives: This study aims to assess the oral health-related quality of life (OHRQoL) among the Irula tribes and to know the factors influencing quality of life among the elderly irula tribes of Tamil Nadu.

Methods: This cross-sectional study was conducted in the Northern district of Tamil Nadu, including 486 Irula individuals aged 65 and above. Participants were selected using a multistage sampling method.

Linking Non-alcoholic Fatty Liver Disease Severity With Metabolic Syndrome Features: An Integrative Study on Clinical and Radiological Fronts.

Introduction Non-alcoholic fatty liver disease (NAFLD) has become a widespread cause of chronic liver disease, ranging from simple steatosis to severe conditions like non-alcoholic steatohepatitis (NASH) and cirrhosis. Despite its similarity to alcohol-induced liver damage, NAFLD affects individuals with no significant alcohol consumption. This study explores the association between NAFLD, bone mineral density (BMD), insulin resistance, and subclinical inflammation, focusing on the Asian Indian population.

A review of extraction and quantification of capsaicin and its bio insecticidal activity in food grains.

Chili peppers pungent and spicy flavor is caused by capsaicin, which is one of their active components. As well as being an important aspect of fruit quality, the hot sensation is a key attribute linked to members of the Capsicum genus. Extraction is one of the most popular techniques for separating and purifying organic materials, but the technique must be quick, affordable, adaptable, efficient, and high performing.

Acute Pneumonia Like Illness and Sepsis in India: Is it Time to Suspect Pulmonary Melioidosis?

This article describes a case of melioidosis, a severe and potentially fatal disease caused by the Gram-negative bacillus , in a 55-year-old female in India. The disease is endemic in Southeast Asia and Northern Australia. Recently there has been an increased number of cases reported in India.

Gd-substituted BiFeO perovskite nanoparticles: facile synthesis, characterization, and applications in heterogeneous catalysis.

We present the combustion-based synthesis of BiFeO (BFO) and Gd:BiFeO perovskite nanoparticles. XRD analysis demonstrates that the undoped BFO ( = 0) perovskite sample shows a single perovskite phase with a rhombohedral structure. However, increase in the Gd content from = 0.

A member of the claudin superfamily influences formation of the front domain in pheromone-responding yeast cells.

Cell polarization in response to chemical gradients is important in development and homeostasis across eukaryota. Chemosensing cells orient toward or away from gradient sources by polarizing along a front-rear axis. Using the mating response of budding yeast as a model of chemotropic cell polarization, we found that Dcv1, a member of the claudin superfamily, influences front-rear polarity.

Knowledge, Attitude and Practices of Contraceptives Among Married Women of Rural Vellore.

Introduction: Ensuring reproductive health is central to the process of developing and improving the health of women and children and is linked to the issues such as sexually transmitted diseases, poverty, education, gender equality, and human rights. This community-based cross-sectional study was conducted to assess the knowledge, attitude, and practices of contraceptives of married women aged 18-49 years in rural Vellore, Tamil Nadu.

Methods: This study was conducted in Kaniyambadi block in Vellore, Tamil Nadu.

Cancer genes disfavoring T cell immunity identified via integrated systems approach.

Adoptive T cell therapies (ACT) have been curative for a limited number of cancer patients. The sensitization of cancer cells to T cell killing may expand the benefit of these therapies for more patients. To this end, we use a three-step approach to identify cancer genes that disfavor T cell immunity.

Formulation and evaluation of oral disintegrating films using a natural ingredient against .

Background: Oral disintegrating films (ODFs) are one of the forms of drug delivery system with better patient compliance. The advantage is that it disintegrates quickly when placed on the tongue and has better bioavailability.

Aim: The aim of this study is to develop an ODF using and targeting .

Pulmonary Vascular Complication Associated With Coronavirus Infection and Role of Lung Resection.

Pulmonary artery pseudoaneurysms are an uncommon diagnosis and have been minimally described in the coronavirus (COVID-19) literature. In our case, a 31-year-old man presented with severe acute hypoxic respiratory failure, stress cardiomyopathy, and combined septic and cardiogenic shock secondary to COVID-19 pneumonia and Streptococcus anginosus bacteremia. The patient had perfusing granulomas eroding into the pulmonary vasculature, causing impending hemothorax.

Effects of COVID-19 on Pregnant women: Evidence-based review.

Corona virus infection (COVID-19) is increasing exponentially globally. It is also affecting pregnant women among others. Complications arising during pregnancy because of COVID-19 must be considered a health issue.

Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies.

T cells are central to all currently effective cancer immunotherapies, but the characteristics defining therapeutically effective anti-tumor T cells have not been comprehensively elucidated. Here, we delineate four phenotypic qualities of effective anti-tumor T cells: cell expansion, differentiation, oxidative stress, and genomic stress. Using a CRISPR-Cas9-based genetic screen of primary T cells we measured the multi-phenotypic impact of disrupting 25 T cell receptor-driven kinases.

Longitudinal Health-related Quality of Life among Individuals Considering Treatment for Stage I Non-Small-Cell Lung Cancer.

Because of improvements in screening, there is an increasing number of patients with early-stage non-small-cell lung cancer (NSCLC) who are making treatment decisions. Among patients with suspected stage I NSCLC, we evaluated longitudinal patient-centered outcomes (PCOs) and the association of changes in PCOs with treatment modality, stereotactic body radiotherapy (SBRT) compared with surgical resection. We conducted a multisite, prospective, observational cohort study at seven medical institutions.

Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells.

Host conditioning has emerged as an important component of effective adoptive cell transfer-based immunotherapy for cancer. High levels of IL-1β are induced by host conditioning, but its impact on the antitumor function of T cells remains unclear. We found that the administration of IL-1β increased the population size and functionality of adoptively transferred T cells within the tumor.

T cell stemness and dysfunction in tumors are triggered by a common mechanism.

A paradox of tumor immunology is that tumor-infiltrating lymphocytes are dysfunctional in situ, yet are capable of stem cell-like behavior including self-renewal, expansion, and multipotency, resulting in the eradication of large metastatic tumors. We find that the overabundance of potassium in the tumor microenvironment underlies this dichotomy, triggering suppression of T cell effector function while preserving stemness. High levels of extracellular potassium constrain T cell effector programs by limiting nutrient uptake, thereby inducing autophagy and reduction of histone acetylation at effector and exhaustion loci, which in turn produces CD8 T cells with improved in vivo persistence, multipotency, and tumor clearance.

Pomegranate extract specifically inhibits growth and toxin production without disturbing the beneficial bacteria in vitro.

Objective: The aim of this study was to assess the pomegranate juice against the growth and toxin production of multidrug-resistant hypervirulent strain NAP1/027/BI and also against the growth of beneficial bacteria to prevent or suppress infection (CDI).

Materials And Methods: Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were taken as parameters for the assessment of antimicrobial property of the pomegranate juice. Four different hypervirulent strains NAP1/027/BI, spp.

Development of cellulose-based migratory and nonmigratory active packaging films.

The main aim of this work is to develop a transparent bioactive cellulose acetate (CA) film for food packaging applications. The aim of the study is also to optimize the production methods for development of bulk and surface immobilized bioactive CA films. The vacuum drying method was optimized for the production of transparent CA films.

Catalytic Conversion of Methanol to Formaldehyde Over La₂CuO₄ Nanoparticles.

La₂CuO₄ (LCO) perovskite nanoparticle was synthesized by microwave assisted combustion method and characterized using X-ray diffraction (XRD), diffuse reflectance spectroscopy (DRS), Fourier transformed infrared spectroscopy (FT-IR), high resolution scanning electron microscopy (HR-SEM) and energy dispersive X-ray analysis (EDX), respectively. The XRD confirmed the formation of a single orthorhombic phase. The average crystallite size of LCO samples were 39.

Effect of film constituents and different processing conditions on the properties of starch based thermoplastic films.

The main aim of this study is to examine the different film preparation methods (Hot air oven method, Microwave oven method, and UV irradiation method) for development of Bio-thermoplastic films from agro waste polysaccharides. The rheological properties were also studied for different combinations of tamarind seed starch (T), okra mucilage polysaccharide (OK), Residual rice bran starch (R) and sugarcane bagasse cellulose (C). Increase in concentration of okra mucilage polysaccharide and sugarcane bagasse cellulose found to highly influence the rheological viscous properties of tamarind starch solution.