Publications by authors named "Sukrit Srisakul"
Article Synopsis
- * Two specific bacteriophages (vB_kpnM_05 and vB_kpnP_08) were isolated from Thai wastewater and demonstrated effectiveness against a high percentage of drug-resistant K. pneumoniae strains, showing rapid replication and stability under different conditions.
- * A phage cocktail combining these two phages alongside the antibiotic amikacin exhibited enhanced antibacterial activity, preventing bacterial regrowth and highlighting a promising therapeutic approach to combat XDR K. pneumoniae infections.
Constipation poses a significant health concern affecting individuals of varying ages and geographic locations worldwide. While the impacts of numerous probiotics on constipation are well-characterized, there has been limited assessment of the potential prebiotic effects of resistant starches. We therefore conducted a randomized, double-blind and placebo-controlled, clinical trial of resistant starch type 3 (RS-3) in Thai adults with self-reported chronic constipation.
View Article and Find Full Text PDFHigh prevalence of mgrB-mediated colistin resistance among carbapenem-resistant Klebsiella pneumoniae is associated with biofilm formation, and can be overcome by colistin-EDTA combination therapy.
Sci Rep
July 2022
The global prevalence of colistin-resistant Klebsiella pneumoniae (ColRkp) facilitated by chromosomal and plasmid-mediated Ara4N or PEtN-remodeled LPS alterations has steadily increased with increased colistin usage for treating carbapenem-resistant K. pneumoniae (CRkp). Our study demonstrated the rising trend of ColRkp showing extensively and pandrug-resistant characteristics among CRkp, with a prevalence of 28.
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- * Genetic analysis found no presence of the mcr gene, but identified key amino acid substitutions in the PmrB protein contributing to colistin resistance through modifications to lipid A.
- * The combination treatment of colistin and sulbactam showed an 86.7% synergy rate against CoR-AB isolates, indicating a promising approach for addressing infections resistant to standard treatments.
Development of an effective therapy to overcome colistin resistance in Klebsiella pneumoniae, a common pathogen causing catheter-related biofilm infections in vascular catheters, has become a serious therapeutic challenge that must be addressed urgently. Although colistin and EDTA have successful roles for eradicating biofilms, no in vitro and in vivo studies have investigated their efficacy in catheter-related biofilm infections of colistin-resistant K. pneumoniae.
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