Publications by authors named "Sukran Yurtogullari"
Article Synopsis
- Ocrelizumab (OCR) shows effectiveness in treating multiple sclerosis (MS) but can lead to a "wearing-off phenomenon" (WoP) prior to infusions.
- A study involving 409 MS patients found that a substantial number experienced WoP symptoms, with many reporting issues like fatigue and walking difficulties four weeks before their next dose.
- Factors such as shorter disease duration and longer intervals between doses were associated with increased WoP occurrence, indicating a need for more personalized treatment approaches.
Introduction: Fingolimod is the first oral immunomodulatory treatment used as secondary care therapy in the treatment of multiple sclerosis for the last 10 years. The objective of our study is to reveal the experiences of the first generic fingolimod active ingredient treatment in different centers across Turkey.
Method: The first generic fingolimod efficacy and safety data of patients followed-up in 29 different clinical multiple sclerosis units in Turkey were analyzed retrospectively.
Multiple sclerosis is a chronic disease characterized by inflammation, demyelination, and axonal damage in the central nervous system. Here, we established an induced pluripotent stem cell (iPSC) line METUi001-A from the peripheral blood mononuclear cells of a 25-year-old male individual with clinically diagnosed Relapsing-Remitting Multiple Sclerosis (RRMS) using the integration-free Sendai reprogramming method. We demonstrated that the iPSCs are free of exogenous Sendai reprogramming vectors, have a normal male karyotype, express pluripotency markers, and differentiate into the three germ layers.
View Article and Find Full Text PDFIntroduction: Cognitive impairment is also an important cause of disability in MS in addition to motor, sensory, visual, and cerebellar affections. The aim of this study is to show the relation between the cognitive disability in MS with brain atrophy and retinal nerve fiber layer (RNFL).
Methods: Forty-three multiple sclerosis (MS) patients, and 15 healthy individuals as controls were included in the study.
Article Synopsis
- The study reviewed the clinical, radiological, and electrophysiological characteristics of 10 patients diagnosed with sporadic Creutzfeldt-Jacob disease (sCJD) among a large group of hospitalized adults from 2000 to 2008.
- Most patients exhibited symptoms like behavioral changes, cognitive decline, and movement disorders, with EEG tests showing periodic sharp wave discharges in nine cases.
- The findings suggest that rapid dementia should prompt consideration of sCJD, as clinical and imaging data can often lead to a diagnosis, though molecular testing may be helpful for identifying different disease subtypes.
Purpose: The aim of this study was to examine the structural-neurochemical abnormalities of the frontal white matter (FWM), deep gray matter nuclei, and pons in patients with Wilson's disease (WD) using proton magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI).
Materials And Methods: Nine patients with WD and 14 age-matched controls were examined with MRS. N-Acetylaspartate (NAA), choline (Cho), and creatine (Cr) peaks were calculated.