[Successful endovascular treatment of proximal deep vein thrombosis following May-Thurner syndrome].

We present two clinical cases of successful endovascular treatment of proximal deep vein thrombosis following May-Thurner syndrome. In the first case, 2-day regional catheter thrombolysis, percutaneous mechanical thrombectomy and venous stenting were required to restore hemodynamics in the left lower limb. In the second case, regional catheter thrombolysis continued for 3 days with subsequent thrombotic mass lysis.

[Endovascular treatment of deep vein thrombosis of the upper extremities].

Objective: To improve the results of treatment of deep vein thrombosis of the upper extremities sing endovascular technologies.

Material And Methods: We analyzed safety and effectiveness of treatment in 24 patients with deep vein thrombosis of the upper extremities. All ones were divided into 2 homogeneous groups by 12 people each.

[Pharmacomechanical thrombectomy for total-subtotal deep vein thrombosis].

Objective: To improve treatment outcomes in patients with late stages of total-subtotal deep vein thrombosis using pharmacomechanical thrombectomy.

Material And Methods: We compared treatment outcomes in 2 homogeneous groups of patients with deep vein thrombosis and severe acute venous insufficiency. Standard anticoagulation (apixaban) was performed in the first group (=20), endovascular treatment was applied in the second group (=20).

[Endovascular surgery for deep vein thrombosis].

The authors reviewed national and world literature data on endovascular technologies for the treatment of deep vein thrombosis. Indications, technologies, complications and results of systemic and regional thrombolysis are described in detail. The authors consider percutaneous mechanical thrombectomy, pharmacomechanical thrombectomy, venous stenting and catheter thrombectomy.

[Regional catheter thrombolysis for late proximal deep vein thrombosis].

Objective: To compare the efficacy of regional catheter thrombolysis with urokinase and alteplase for late proximal deep vein thrombosis.

Material And Methods: We analyzed safety and effectiveness of treatment of 38 patients with late proximal deep vein thrombosis divided into 2 statistically homogeneous groups by 19 people. In the first group, regional thrombolysis with urokinase was performed with injection of the drug into thrombosed popliteal, femoral and iliac veins.

[Venous stenting in acute period of total and subtotal deep vein thrombosis].

Objective: To study the efficacy and safety of venous stenting and long-term anticoagulation with inhibitors of blood clotting factor XA in the treatment of total and subtotal deep vein thrombosis.

Material And Methods: We analyzed 60 patients with total and subtotal deep vein thrombosis divided into 2 comparable groups by 30 people. Patients of the first group underwent regional catheter thrombolysis and percutaneous mechanical thrombectomy.

[Local management of purulent wounds with wound dressings].

Purulent-inflammatory lesions of skin and soft tissues account for 30-35% of causes of admission to surgical hospitals. In outpatient system, this value reaches 35-60%. Moreover, suppuration of wounds after elective surgery occurs in 2-5% of cases.

[Efficacy of percutaneous mechanical thrombectomy for proximal deep vein thrombosis].

Objective: To study the efficacy and safety of percutaneous mechanical thrombectomy and long-term anticoagulation with rivaroxaban for proximal deep vein thrombosis.

Material And Methods: We analyzed the effectiveness of treatment in 60 patients with proximal deep vein thrombosis divided into 2 homogeneous groups by 30 people. Standard therapy was performed in the first group, therapy with percutaneous mechanical thrombectomy was applied in the second group.

[Acute cerebral circulation impairment associated with percutaneous coronary intervention].

The article deals with generalized literature data on the current importance of the problem concerning acute cerebral ischemia occurring during percutaneous coronary interventions. Pathophysiological mechanisms of the development of acute cerebral circulation impairment are described, with their classification. Also considered are various risk factors which may cause this formidable complication, followed by describing modern methods of its surgical treatment.

[Case of effective endovascular treatment of venous gangrene].

Presented in this article is a clinical case report regarding treatment of a patient with deep vein thrombosis complicated by venous gangrene having developed 10 days after the onset of the disease. Conservative therapy (infusion of colloids and crystalloids, anticoagulants, agents improving microcirculation, venotonics, nonsteroidal anti-inflammatory drugs, elevated position of the limb) made it possible to stabilize the patient's condition, but not improving haemodynamics of the affected limb. A decision was made to use endovascular techniques.

[Cardiac ruptures in acute myocardial infarction].

Presented in the article are the generalized data of the Russian and foreign literature addressing the currently important problem of myocardial ruptures as one of the most dangerous complications of infarction, also analysing the results of clinical studies on interconnection of heart ruptures with systemic thrombolytic therapy and with a percutaneous coronary intervention. This is followed by describing the mechanisms that may lead to myocardial rupture during thrombolytic therapy and surgical endovascular treatment, underlying the necessity of pharmacological pre- and post-conditioning for prevention of reperfusion myocardial lesions. The article also touches upon the clinical and instrumental diagnosis of myocardial ruptures, as well as approaches to surgical treatment depending on the type of rupture and necessity of myocardial revascularization.

[Efficacy of apixaban in prevention of haemorrhagic complications in treatment of deep vein thromboses with endovascular techniques].

Purpose: This study was undertaken to investigate efficacy of apixaban in prevention of haemorrhagic complications during treatment of proximal thromboses of deep veins of the lower extremities using endovascular techniques.

Patients And Methods: We retrospectively studied the results of treating a total of 50 patients presenting with deep vein thromboses at late stages of the pathological process. The patients were subdivided into 2 statistically homogeneous groups.

[One-year results of conservative and endovascular treatment of deep venous thrombosis followed by severe acute venous insufficiency].

Objective: To compare the results of conservative and endovascular treatment of deep vein thrombosis followed by acute severe venous insufficiency.

Material And Methods: Two statistically valid groups of patients with deep vein thrombosis and acute severe venous insufficiency were compared. Warfarin was administered in the first group, endovascular methods - in the second group (=30).

[Effect of the type of a coronary stent on dynamics of quality of life in patients with ischaemic heart disease].

The purpose of the present study was to investigate the dynamics of quality of life in patients with ischaemic heart disease before and after implantation of a coronary stent depending on the stent's type and patient's gender. The authors analysed the dynamics of quality of life in a total of 120 patients with ischaemic heart disease. The patients were subdivided into two equal groups of 60 each.

[Efficacy of treatment of lower-limb critical ischaemia by methods of indirect revascularization].

Aim: The study was aimed at comparing the efficacy of implantation of autologous bone marrow cells with that of revascularizing osteotrephination in treatment of lower limb chronic critical ischaemia in patients with a poor distal vascular bed.

Patients And Method: We analysed the results of comprehensive examination and treatment of a total of 60 patients presenting with lower limb chronic critical ischaemia due to atherosclerotic lesions of the femoropopliteal-tibial segment. According to the technology of treatment, the patients were divided into two statistically homogenous groups of 30 people each.

[Efficacy of Detragel in treatment of varicothrombophlebitis in elderly and aged patients].

Aim: The present study was aimed at improving the results of treatment in elderly and aged people by means of local therapy with 'Detragel'.

Patients And Methods: The authors analysed the results of comprehensive examination and treatment of 60 elderly and aged patients presenting with acute varicothrombophlebitis and severe somatic diseases. Depending on the method of treatment, the patients were subdivided into 2 statistically homogeneous groups consisting of 30 patients each.

[Choice of reconstructive operation in lesions of femoropopliteotibial segment and dubious outflow pathways].

We analysed the results of surgical treatment of 40 patients with lower limb critical ischaemia induced by atherosclerotic lesion of arteries of the femoropopliteotibial segment with dubious outflow pathways. The patients were divided into two groups of 20 each. Group One patients underwent autovenous femoropopliteal or tibial bypass grafting below the fissure of the knee joint and Group Two patients were subjected to profundoplasty with closure of the arteriotomic opening with an autovenous patch.

[Reaction of connective tissue of arterial and venous walls to implantation of synthetic and biological grafts].

Background: 30% of patients in the remote period appear to develop restenosis of the anastomoses formed during reconstructive-restorative operations on vessels. Two major causes of restenosis have been determined: intimal hyperplasia and smooth muscle cell proliferation. The reaction of connective-tissue elements of vascular walls in response to implantation of grafts remains unstudied.

[Role of TGFβ1 and VEGF-А gene polymorphisms in development of chronic obliterating diseases of lower-limb arteries].

The study was aimed at investigating the interrelationship of gene polymorphisms of transforming growth factor (TGFβ1) and endothelial vascular growth factor (VEGF-A) with the risk for the development of chronic obliterating diseases of lower-limb arteries (CODLLA) in the Russian population of Central Russia. We studied polymorphism C-509T of the TGFβ1 gene and polymorphism +936C>T of the VEGF-A gene in 202 patients with CODLLA and in 148 apparently healthy individuals. Genomic DNA was isolated by the standard method of phenol-chloroform extraction.

[Effectiveness of biological prosthesis for femoro-femoral bypass in high risk patients].

Aim: To compare synthetic and biological prostheses for femoral bypass surgery.

Material And Methods: There were 40 patients with critical ischemia of lower extremities due to atherosclerotic lesion of aorto-iliac segment and severe comorbidities. They were divided into 2 groups by 20 patients.

[Results of administering oral anticoagulants for treatment of patients with venous thromboembolic complications].

The objective of the study was to compare safety and efficacy of rivaroxaban and dabigatran with warfarin in treatment of patients with acute venous thromboembolic complications (VTEC). The authors analysed the results of examining and treating a total of 95 patients presenting with VTEC and randomly divided into three groups. In all groups the initial anticoagulant therapy consisted in unfractionated heparin administered for 5 days, after which the patients followed by switching were switched to a 6-month course of treatment with oral anticoagulants.

[Stimulation of angiogenesis by bone marrow cells in experimental ischaemia of lower limb].

The objective of the study was to experimentally substantiate a possibility of treating lower limb chronic ischaemia by means of administration of bone marrow cells. The study was performed on 100 laboratory 'Wistar' rats subdivided into four groups: intact, control, first and second study groups. The intact group consisted of 10 animals, with the remaining three containing 30 rats each.

[Effect of actovegin and solcoseryl on microcirculation in experimental critical lower limb ischaemia].

The authors examined the effect of actovegin and solcoseryl on microcirculation parameters in treatment of experimental critical lower limb ischaemia. The study included a total of 130 male Wistar albino rats divided into four groups: intact, control, first and second study groups. The intact group consisted of 10 animals used for assessment of the normal indices of microcirculation, with the remaining three groups comprising 40 rats each.

[Results of using various methods of autovenous femoropopliteal bypass grafting below the knee-joint fissure].

The objective of the study was to improve therapeutic outcomes in patients presenting with lower limb critical ischaemia by means of optimizing the technique of femoropopliteal bypass grafting. The authors analysed the results of comprehensive examination and treatment of a total of 90 patients presenting with critical lower limb ischaemia on the background of atherosclerotic lesions of arteries of the femoropopliteal and crural segments. Depending on the technology of performing femoropopliteal bypass grafting, the patients were subdivided into three groups each consisting of 30 subjects.

[CHOICE OF PROSTHESIS IN AXILLOFEMORAL BYPASS IN PATIENTS WITH HIGH RISK AND MULTILEVEL LESIONS OF LOWER LIMB ARTERIES].

An analysis of results of experimental research was made in 60 patients with critical ischemia of lower extremities due to bilaterally atherosclerotic lesions of aorto-iliac segment, which had a high operationally anaesthetic risk. Synthetic polytetrafluoethylene prosthesis or biological shunt from internal pectoral bull arteries were used as a shunt. Revasculization was performed through the system of arteria profunda femoris considering multilevel lesions of lower limb arteries.