Publications by authors named "Sukhdeep Singh"

In the present investigation, friction stir welding (FSW) of a gamma prime (γ') strengthened Haynes 282 nickel-base superalloy by using a novel hemispherical tool is documented. A joint efficiency of ~ 96% was achieved in the as-welded condition, which further increased to ~ 100% after two-step post-weld aging heat treatment. An extremely fine (~ 2 μm) grained microstructure was observed in the FSWed region compared with the coarse (~ 48 μm) grain base metal region.

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  • Chronic inducible urticaria (CIndU) lasts longer than 6 weeks and is triggered by specific factors, but research on its severity and treatment is limited compared to chronic spontaneous urticaria (CSU).
  • A study reviewed data from 222 CIndU patients and 226 CSU controls, finding that both groups were similar in age and gender, but CIndU patients had significantly lower CRP levels and a poorer quality of life score (CU-QOL).
  • CIndU patients required more frequent antihistamine adjustments (80% vs. 52% in CSU) and took longer to achieve remission, averaging 60 days compared to 27.77 days for CSU patients.
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Aims And Background: To evaluate and compare pain perception with Septoject XL and conventional needles in 6-8 years old children.

Materials And Methods: In this split-mouth randomized controlled trial, a single-blinded study, 24 children (6-8 years) were assigned at random to receive the local anesthetic (LA) injection for treatment needs either with Septoject XL or conventional needle for the first visit in one of the quadrants, while during the second visit in a different quadrant with the other one. Children's pain levels were assessed during each visit using an objective sound eye motor (SEM) scale and subjective Wong-Baker faces rating scale (FRS).

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  • A 70-year-old woman had a single wart-like growth on her leg and painful sores in her mouth.
  • Doctors considered possible conditions like lichen simplex chronicus and chromoblastomycosis before diagnosing her with pemphigus vegetans (PVeg).
  • This case emphasizes the need to include PVeg in diagnoses for unusual skin growths, even when they appear in unexpected areas of the body.
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Reconstruction of through-and-through defects of cheek and commissure resulting from cancer resection are challenging. The specialized function of oral competence that the oral commissure and lip play is difficult to replicate with flap only reconstruction. Static slings play an important role in improving the functional and aesthetic outcome.

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The introduction of AlphaFold 2 has spurred a revolution in modelling the structure of proteins and their interactions, enabling a huge range of applications in protein modelling and design. Here we describe our AlphaFold 3 model with a substantially updated diffusion-based architecture that is capable of predicting the joint structure of complexes including proteins, nucleic acids, small molecules, ions and modified residues. The new AlphaFold model demonstrates substantially improved accuracy over many previous specialized tools: far greater accuracy for protein-ligand interactions compared with state-of-the-art docking tools, much higher accuracy for protein-nucleic acid interactions compared with nucleic-acid-specific predictors and substantially higher antibody-antigen prediction accuracy compared with AlphaFold-Multimer v.

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Plastics are versatile materials, offering lightweight, durable, and affordable solutions across various industries. However, their non-degradable nature poses challenges by end of their life. This study presented an innovative carbonyl extraction method to utilize waste poly(bisphenol A carbonate) (PC) as reaction precursor to synthesis of activated furan as precursor for photoswitchable Stenhouse adducts.

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Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is an idiosyncratic severe cutaneous adverse reaction that may be potentially life-threatening. Recently, a simple scoring system for the early screening of DRESS patients was derived by combining hsCRP levels, the eosinophil count, and the total body surface area (CET score). The objectives of this study were validating the CET score, and calculating its lead time advantage and cost-benefits compared to RegiSCAR scoring.

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