Pre-Holocene Taymyr Mammoth Petya: Mineralogical, Isotope, and Geochemical Properties of Bones, Soft Tissues, Skin, and Hair and Paleoecological Reconstructions.

New remains of a Taymyr mammoth, including bones, bone collagen, hairs, skin, and soft (muscle and fat) tissues were studied comprehensively by mineralogical, spectroscopic, chromatographic, and isotope-geochemical methods. The results were used to infer the mammoth's biological age and diet, paleoclimatic conditions, and the mechanisms and degree of fossilization of the remains.

Risankizumab for the Treatment of Moderate to Severe Plaque Psoriasis in the Russian Federation.

Introduction: Risankizumab has demonstrated efficacy and safety in phase 3 studies in patients with moderate to severe plaque psoriasis. This randomized clinical trial assessed the efficacy and safety of risankizumab in patients with moderate to severe plaque psoriasis in the Russian Federation.

Methods: Patients with moderate to severe plaque psoriasis were randomized 4:1 to 16 weeks of double-blind treatment with risankizumab 150 mg or placebo (period A; dosing at baseline and week 4) followed by an open-label extension (period B) during which all patients received risankizumab 150 mg at weeks 16, 28, and 40 and were followed up to week 52.

TROPHY registry - status report.

Introduction: The TROPHY registry has been established to conduct an international multicenter prospective data collection on the surgical management of neonatal intraventricular hemorrhage (IVH)-related hydrocephalus to possibly contribute to future guidelines. The registry allows comparing the techniques established to treat hydrocephalus, such as external ventricular drainage (EVD), ventricular access device (VAD), ventricular subgaleal shunt (VSGS), and neuroendoscopic lavage (NEL). This first status report of the registry presents the results of the standard of care survey of participating centers assessed upon online registration.

A Structural Model of the Inactivation Gate of Voltage-Activated Potassium Channels.

After opening, the Shaker voltage-gated potassium (K) channel rapidly inactivates when one of its four N-termini enters and occludes the channel pore. Although it is known that the tip of the N-terminus reaches deep into the central cavity, the conformation adopted by this domain during inactivation and the nature of its interactions with the rest of the channel remain unclear. Here, we use molecular dynamics simulations coupled with electrophysiology experiments to reveal the atomic-scale mechanisms of inactivation.

[Planning and organization of allo-grafting performed on the soldier's face].

Planning and organisation of allo-grafting performed on the soldier's face. According to the experience of military conflicts facial trauma with the Ioss of person's social function occurs in 4,5-5% of patients with such injury. In most cases, these injuries can be fixed with the help of reconstructive plastic surgery using their own tissue.

[DIRECT REVASCULIZATION OF THE MYOCARDIUM FROM LEFT-SIDE MINITHORACOTOMY - MODERN PERFORMANCE OF THE OPERATION NAMED AFTER V.I. KOLESOV].

The article provides the results of minimally invasive direct revasculization of myocardium at the period from 2012 to 2014. Given method was used in 49 interventions. There weren't any lethal cases or myocardial infarctions.

Optical beam distortions induced by a shock wave.

The mean intensity and the displacement from the initially given propagation direction of the optical beam passed through the shock wave have been calculated. It has been shown that the spatial inhomogeneity of the refractive index of air caused by the shock wave arising in supersonic flow flowing a conical body can cause the focusing of the beam and strong anisotropic distortions of the intensity distribution in its cross section. The angular displacement of the optical beam from the initially given propagation direction owing to the shock wave depends only on the height above the Earth's surface at which the shock wave is formed.

[Experience of left ventricular assist device "Incor" as "bridge to recovery" implantation in patients with end stage congestive heart failure].

Left ventricular assist device "Incor" ("Berlinhear", Germany) implantation experience in patient with ischemic cardiomiopathy and severe congestive heart failure is presented. Left ventricular assist device implantation was followed by coronary artery bypass grafting simultaneously. Total assist time was 211 days.

[The medical social and psychological issues of women with mastopathy].

The study revealed that 92.5% of female patients consulted by themselves the physician on the subject of mastopathy were town inhabitants with secondary special and humanitarian higher education from the white-collar social group. The concomitant diseases of digestial organs and urogenital system and the deviant psychological characteristics of personality as well had been registered reliably much more frequently among women with a mastopathy in comparison with the control group.

[Immunochemical studies of salivary lactoferrin].

Immunodiffusion assays were used to examine lactoferrin (LF) in the mixed saliva of 1026 patients and 553 apparently healthy individuals. Elevated salivary LF levels were found in respiratory and digestive diseases and diabetes. It is concluded that this non-invasive immunochemical assay is promising in the screening and monitoring of persons during their health examination.

[The forming of child and adolescent adaptability].

Adaptability is an ability of the organism to spend its functional reserve in order to keep the balance with the environment and then make up for the use of this reserve. The adaptation of a growing organism to the environment is an intersystem process. The condition of functional intersystem regulation and cardiac rhythm variability in particular, serve as indicators of child adaptability.

[Gender differences in health status and life quality of students].

The study has revealed that the leading hygienic risk factor of disorders and low life quality in medical students are an excess educational load at the expense of lecture and extra lecture hours, which is not characteristic of engineering students for whom the organization of a training process mostly meets the sanitary requirements. Gender differences have been found in life quality assessed by young males and females. Social factors have been proved to be the most significant parameters modifying the student's life quality.

[The health status of children under poor ecological and social conditions].

In the Republic of Altai, the past decades are marked by poor trends in the children's health status: lower birth rates, a rise in general and infantile mortality and morbidity and worse physical development. The districts and areas that differ in environmental and social characteristics have been identified. Their comparison has determined the influence of environmental and social factors on the health status of children.

[Guidelines for comprehensive assessment of educational and training conditions of children and adolescents].

General guidelines have been developed to make a comprehensive assessment of the conditions of education and teaching and to predict probable changes in preschool- and schoolchildren's health. The guidelines envisage the use of standard procedures and programmes for the assessment and optimization of educational and teaching conditions for children and adolescents in educational establishments of different types.

[Scientific bases of a concept of promotion of health of children and adolescents].

The paper outlines theoretical concepts on society-state-individual to reduce mortality, morbidity, and disability among children and adolescents and to increase physical and social fitness at the stage of human maturation. On implementation of the concepts, the author proposed to follow the following principles: 1) their governmental nature and priority of preventive measures; 2) the structurization of measures by levels (federal, regional); 3) the optimization of resources and financing; 4) interdisciplinary integration and intersectoral cooperation.

[Clinico-diagnostic role of ferritin and lactoferrin assays in benign and malignant affections of lungs and pleura].

Immunochemical tests of blood sera from 160 healthy residents of the town of Astrakhan were performed to determine standard quantities of ferritin and lactoferrin in the serum. Examinations of the saliva from 280 healthy subjects provided the frequency of occurrence and levels of excretory lactoferrin. These iron-containing proteins were also assessed in different biosubstrates (blood serum, sputum, saliva, pleural fluid, lung tissues) from 550 patients with benign and malignant lesions of the lungs and pleura.

[Study of salivary lactoferrin in prophylactic examinations].

Immunochemical testing of salivary samples of 73 patients revealed a positive correlation between increased level of lactoferrin and the presence of chronic pancreatoduodenal diseases (gastroduodenitis, gastroduodenal ulcers, polyps of the antral portion of the stomach, cholecystitis, cholangitis, cholelithiasis, hepatitis, and pancreatitis, correlation coefficient 0.9). The test is proposed as a cheap and informative method for screening of the above diseases.