Simple, sensitive and reliable in vivo assays to evaluate the estrogenic activity of endocrine disruptors.

Purpose: We compared three in vivo assays, determining changes of body weight, and uterotropic and vaginal cytology assays, for the evaluation of estrogenic activity of an estrogen disrupting compound, (PM), in comparison with 17β-estradiol (E).

Methods: Female rats were ovariectomized and gavaged with distilled water, 0.01, 0.