Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes.

While apolipoprotein E (APOE) is the strongest genetic modifier for late-onset Alzheimer's disease (LOAD), the molecular mechanisms underlying isoform-dependent risk and the relevance of ApoE-associated lipids remain elusive. Here, we report that impaired low-density lipoprotein (LDL) receptor (LDLR) binding of lipidated ApoE2 (lipApoE2) avoids LDLR recycling defects observed with lipApoE3/E4 and decreases the uptake of cholesteryl esters (CEs), which are lipids linked to neurodegeneration. In human neurons, the addition of ApoE carrying polyunsaturated fatty acids (PUFAs)-CE revealed an allelic series (ApoE4 > ApoE3 > ApoE2) associated with lipofuscinosis, an age-related lysosomal pathology resulting from lipid peroxidation.

Active maintenance of working memory contents affects functioning of attentional filtering.

Salient objects are well known to capture attention. Furthermore, a stimulus associated with the attention-capturing objects could infiltrate into working memory. This was recently formulated as filter disruption theory.

The Involvement of the Multiple Demand and Default Mode Networks in a Trial-by-Trial Cognitive Control.

Adaptive behavior in the environment requires a high level of cognitive control to bias limited processing resources to behaviorally significant stimuli. Such control has been associated with a set of brain regions located in the fronto-parietal cortex (multiple demand network), whose activity was found to increase as the control demand for a task increases. In contrast, another set of regions, default mode network regions, were found to be deactivated during top-down processing of task stimuli.

Stimulus Heterogeneity in a Task-Irrelevant Dimension Affects Selective Attention.

When multiple stimuli are simultaneously presented, they compete against each other to be represented in the capacity-limited visual system. This competition increases as stimulus heterogeneity increases. Given that selective attention is a way to resolve this competition, it has been known that the effect of attention on task performance is magnified as the level of competition increases due to increased stimulus heterogeneity.

Healthy lifestyle interventions for childhood and adolescent cancer survivors: a systematic review and meta-analysis.

Purpose: This study investigated the effects of healthy lifestyle interventions (HLSIs) on health-related quality of life (HR-QoL) in childhood and adolescent cancer survivors (CACS).

Methods: Major databases were searched for English-language original articles published between January 1, 2000 and May 2, 2021. Randomized controlled trials (RCTs) and non-RCTs were included.

Improved natural food colorant production in the filamentous fungus Monascus ruber using CRISPR-based engineering.

Monascus pigments have various food industry applications and are pharmacologically active. Genome sequencing-based clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology has been implemented to increase pigment production in Monascus. To increase pigment production in M.

Perceptual integration modulates dissociable components of experience-driven attention.

To interact efficiently with the visual environment, one perceptually integrates fragmented visual inputs into complete units. Another approach is to rely on previous experience to determine what should receive attention and what should be discarded. While both perceptual integration and learning experiences have been found to influence attentional selection, the interaction between these processes remains unexplored.

Safety evaluation of mycotoxin citrinin production from through whole-genome sequencing and analytical evaluation.

In this study, the whole genome of KACC 46666 was generated using the PacBio RSII sequencer with high-quality de novo assembly to obtain trustworthy assembly and annotation using genome assemblies with long reads from PacBio single-molecule real-time sequencing. The whole genome of has a total length of 25.9 Mb, divided in 13 contigs with 9639 genes.

Neurocognitive Mechanisms Underlying Internet/Smartphone Addiction: A Preliminary fMRI Study.

The present study investigated the neurocognitive mechanisms underlying smartphone/internet addiction. We tested a specific hypothesis that the excessive, uncontrolled use of smartphones should be related to the ability of controlling attention in a purely endogenous and self-regulatory manner. In an fMRI experiment, in which 43 adults participated, we had participants detect and identify specified target stimuli among non-targets.

Research trends related to childhood and adolescent cancer survivors in South Korea using word co-occurrence network analysis.

Purpose: This study analyzed research trends related to childhood and adolescent cancer survivors (CACS) using word co-occurrence network analysis on studies registered in the Korean Citation Index (KCI).

Methods: This word co-occurrence network analysis study explored major research trends by constructing a network based on relationships between keywords (semantic morphemes) in the abstracts of published articles. Research articles published in the KCI over the past 10 years were collected using the Biblio Data Collector tool included in the NetMiner Program (version 4), using "cancer survivors", "adolescent", and "child" as the main search terms.

Comparing the temporal dynamics and efficacy of task-relevant and task-irrelevant memory-driven attention.

People's attention is well attracted to a stimulus matching their memory. For example, when people are required to remember the color of a visual object, stimuli matching the memory color powerfully capture attention. Remarkably, stimuli with the shape of the memory object, that is, irrelevant-matching stimuli were also found to capture attention.

CRISPR/Cas9-mediated Inactivation of arginase in a yeast strain isolated from Nuruk and its impact on the whole genome.

Despite the advantages of CRISPR/Cas9 technology in the food industry, controversy over its off-target effects exists. We engineered an industrial Saccharomyces cerevisiae strain isolated from a Korean rice wine starter, Nuruk, using CRISPR/Cas9 to decrease ethyl carbamate (EC) formation. We disrupted the CAR1 gene encoding arginase, which plays a key role in EC formation.

The role of right temporo-parietal junction in stimulus evaluation.

A predominant model of the temporo-parietal junction (TPJ) claims that this region is critical for attentional orienting/reorienting toward an unexpected, but behaviorally significant stimulus. However, recent studies have suggested that the TPJ is also involved in the process of evaluating stimulus, especially matching between external sensory inputs and internal representations. While some studies provide evidence for the involvement of the TPJ in stimulus evaluation, the nature of the evaluative process mediated by the TPJ remains unclear.

Top-down control of attention under varying task loads.

The performance of a goal-directed task is often interrupted by task-irrelevant distractors. This distractor interference has well been demonstrated in a large body of studies employing the Eriksen flanker paradigm. A notable finding regarding this issue is that distractor interference is attenuated by increased perceptual load or the presence of non-target stimuli diluting distractors.

Serial, self-terminating search can be distinguished from others: Evidence from multi-target search data.

How do people find a target among multiple stimuli? The process of searching for a target among distractors has been a fundamental issue in human perception and cognition, evoking raging debates. Some researchers argued that search should be carried out by serially allocating focal attention to each item until the target is found. Others claimed that multiple stimuli, sharing a finite amount of processing resource, could be processed in parallel.

Sharper attentional tuning with target templates in long-term compared to working memory.

Theories of attention postulate the existence of an attentional template containing target features in working or long-term memory. Previous research has shown that these internal representations of target features in memory are shifted away from nontarget features and that attention is tuned to the shifted feature especially when the target appeared with similar nontarget items. While previous studies have shown that the target-nontarget relationship has influence on the attentional selection and the representation shift when attentional template is maintained in long-term memory, there is little evidence for such effects when attentional template is stored in working memory.

Validation of the Disaster Preparedness Evaluation Tool for Nurses-The Korean Version.

(1) Background: The purpose of this study was to validate a Korean version of the disaster preparedness evaluation tool (DPET-K) for nurses and to verify its validity and reliability for use in community healthcare centers and hospitals in South Korea; (2) Methods: In total, 497 nurses (248 for exploratory factor analysis and 249 for confirmatory factor analysis) at public health centers, public health sub-centers, public health clinics, and general hospitals in Seoul and Gyeonggi, Chungcheong, and Gangwon Provinces participated in this study. The tool went through translation and back-translation, content validity verification, a pilot survey, and validity and reliability testing; (3) Results: The DPET-K had 28 items with five factors (disaster education and training, disaster knowledge and information, bioterrorism and emergency response, disaster response, and disaster evaluation). The Cronbach's α values for internal consistency were 0.

Response of multiple demand network to visual search demands.

Neuroimaging studies for human participants have shown that the activity in the multiple-demand (MD) network is associated with various kinds of cognitive demand. However, surprisingly, it remains unclear how this MD network is related to a core component of cognition, the process of searching for a target among distractors. This was because previous neuroimaging studies of visual search were confounded by task difficulty or time on task.

Visual search proceeds concurrently during the attentional blink and response selection bottleneck.

It is well known that human information processing comprises several distinct subprocesses-namely, the perceptual, central, and motor stage. In each stage, attention plays an important role. Specifically, a type of attention-perceptual attention-operates to detect and identify a sensory input.

Fouling and performance of outer selective hollow fiber membrane in osmotic membrane bioreactor: Cross flow and air scouring effects.

This study assessed impacts of cross-flow velocity (CFV) and air scouring on the performance and membrane fouling mitigation of a side-stream module containing outer-selective hollow fiber thin film composite forward osmosis membrane in osmosis membrane bioreactor (OMBR) system for urban wastewater treatment. CFV of draw solution was optimized, followed by the impact assessment of three CFVs on feed solution (FS) stream and periodic injection of air scouring into the side-stream module. Overall, the OMBR system exhibited high and stable performance with initial water flux of approximately 15 LMH, high removal efficiencies of bulk organic matter and nutrients.

Opposing effects of stimulus-driven and memory-driven attention in visual search.

When one searches for a specific target in a cluttered visual scene, a perceptually salient stimulus or a stimulus that matches working memory's contents is prioritized for attentional selection. In the present study, we aimed at clarifying under which circumstance stimulus-driven attention or memory-driven attention is more pronounced. We hypothesized that one crucial factor affecting stimulus-driven versus memory-driven attention is how a concurrent visual search task is performed.

Cue frequency modulates cuing effect either in the presence or in the absence of distractors.

A novel, salient stimulus, even though it is not related to a concurrent goal-directed behavior, powerfully captures people's attention. While this stimulus-driven attentional capture has long been presumed to take place in a purely bottom-up or automatic manner, growing evidence shows that a number of top-down factors modulate the stimulus-driven capture of attention. Recent studies pointed out the cue presentation frequency is such a factor; the capture of attention by a salient, task-irrelevant cue increased as its presentation frequency decreased.

Ferromagnet-Free All-Electric Spin Hall Transistors.

The spin field-effect transistor, an essential building block for spin information processing, shows promise for energy-efficient computing. Despite steady progress, it suffers from a low-output signal because of low spin injection and detection efficiencies. We demonstrate that this low-output obstacle can be overcome by utilizing direct and inverse spin Hall effects for spin injection and detection, respectively, without a ferromagnetic component.

Search efficiency is not sufficient: The nature of search modulates stimulus-driven attention.

It has long been debated whether or not a salient stimulus automatically attracts people's attention in visual search. Recent findings showed that a salient stimulus is likely to capture attention especially when the search process was inefficient due to high levels of competition between the target and distractors. Expanding these studies, the present study proposes that a specific nature of visual search, as well as search efficiency, determines whether or not a salient, task-irrelevant singleton stimulus captures attention.