Comprehensive insights into UTIs: from pathophysiology to precision diagnosis and management.

Urinary tract infections (UTIs) are the second most common infectious disease, predominantly impacting women with 150 million individuals affected globally. It increases the socio-economic burden of society and is mainly caused by , , , spp., and spp.

Toxicity prediction and analysis of flavonoid apigenin as a histone deacetylase inhibitor: an in-silico approach.

Occurrence of cancer is driving up on a global scale that exerts greater implications on the physical, psychological and economic stability of the human population. In the present context, numerous research studies are being conducted to explore and discover the drug molecule as an anticancer agent. Diverse scales of flavonoids entail the human diet, and they displayed prospective curative effects against an array of ailments.

Donor-Derived Cell-Free DNA and Active Rejection in Renal Allografts.

Background: Renal allograft rejection contributes to significant morbidity and graft loss. In this setting, early detection of rejection is of paramount importance, which currently relies on histopathology. A reliable non-invasive marker to predict rejection would make surveillance and decision-making easier.

Acute Kidney Injury in a Tertiary Care Center of South India.

Background And Objective: Data regarding the epidemiology and outcomes of acute kidney injury (AKI) from our part of the world are limited. The irking consequences of AKI, both on the patient and the health care system, are being increasingly recognized. We aimed to study the epidemiology and short-term outcomes of AKI and to analyze the factors associated with adverse renal outcomes.

Association of IgA Nephropathy with Squamous Cell Carcinoma of the Tongue: - Case Report and Review of Literature.

A 32-year-old habitual tobacco chewer was diagnosed with squamous cell carcinoma of the tongue. He was initiated on chemo-radiation therapy. After completing 23 cycles of radiation and four cycles of cisplatin-based chemotherapy, he presented with acute nephritic syndrome.

Experimental investigations on viscosity and density of eco-friendly MoS-sesame oil nano-lubricants and its influence on pumping power.

In this study, the rheological behavior and density of MoS/sesame oil based nano-lubricants are experimentally investigated. The transmission electron microscopy and x-ray diffraction technique were utilized to confirm the morphology of the MoSnano particles. The experimental measurements are carried out at temperature varying from 313 to 393 K, shear rate ranging from 10to 70 sand solid volume fraction ranging from 0.

Leukocytoclastic Vasculitis Associated with Bortezomib Therapy.

A 28-year-old male, 10 years post live-related renal transplant with stable graft function of 1.4 mg/dL, presented with complaints of loss of appetite and vomiting for three days. On evaluation, he was found to have significant graft dysfunction with a creatinine of 10.

An epidemiological study to assess periodontal status among sugar factory workers of Karad taluka using community periodontal index.

Objectives: Oral health is an integral component of general health. Periodontal disease is one of the most prevalent dental diseases among the population. Researchers have identified an association of various risk factors with periodontal disease.

Lupus nephritis in a patient with retroviral infection.

A 38-year-old woman, diagnosed as Person Living with Human Immunodeficiency Virus (HIV) on Highly Active Antiretroviral Therapy (HAART) for three years, presented with features of fever, rashes, joint pain, dyspnea and pedal edema. On evaluation, a diagnosis of Systemic Lupus Erythematosus with Lupus Nephritis (LN) triggered by HIV infection was made based on clinical and serological evidence. She was continued on HAART, and immuno-suppressive therapy was co-administered resulting in the resolution of her symptoms.

Tuning the photophysical properties of carboranyl luminophores by closo- to nido-carborane conversion and application to OFF-ON fluoride sensing.

A family of closo-carborane-appended luminophores (closo-OXD1-2 and closo-DPS1-2) in which 2-R-o-carboranes (R = H, Me) are attached to the diphenyl-1,3,4-oxadiazole (OXD) or diphenyl-sulfone (DPS) acceptor groups were prepared and characterized. Deboronation of the closo-carborane cage produced the corresponding nido-carboranyl luminophores (nido-OXD1-2 and nido-DPS1-2). Whereas the closo-compounds were poorly emissive in THF (ΦPL < 0.

Nido-Carboranes: Donors for Thermally Activated Delayed Fluorescence.

An approach to the design of nido-carborane-based luminescent compounds that can exhibit thermally activated delayed fluorescence (TADF) is proposed. 7,8-Dicarba-nido-undecaboranes (nido-carboranes) having various 8-R groups (R=H, Me, i-Pr, Ph) are appended to the meta or para position of the phenyl ring of the dimesitylphenylborane (PhBMes ) acceptor, forming donor-acceptor compounds (nido-m1-m4 and nido-p1-p4). The bulky 8-R group and meta substitution of the nido-carborane are essential to attain a highly twisted arrangement between the donor and acceptor moieties, leading to a very small energy splitting between the singlet and triplet excited states (ΔE <0.

Rapidly progressive glomerulonephritis due to anti-glomerular basement membrane disease accompanied by IgA nephropathy: An unusual association.

Anti-glomerular basement membrane (anti-GBM) disease is a systemic autoimmune disorder characterized by circulating IgG antibodies (rarely IgA and IgM) to the carboxyterminal, noncollagenous 1 (NC1) domain of type IV collagen of GBM also known as Goodpasture antigen. Patients typically present with rapidly progressive glomerulonephritis (RPGN) and pulmonary hemorrhage in the presence of which it is referred to as Goodpasture's disease. Anti-GBM disease has been reported to coexist with pauci-immune antineutrophil cytoplasmic autoantibody-positive glomerulonephritis and membranous glomerulopathy.

Burning Mouth Syndrome.

Burning mouth syndrome (BMS) is multifactorial in origin which is typically characterized by burning and painful sensation in an oral cavity demonstrating clinically normal mucosa. Although the cause of BMS is not known, a complex association of biological and psychological factors has been identified, suggesting the existence of a multifactorial etiology. As the symptom of oral burning is seen in various pathological conditions, it is essential for a clinician to be aware of how to differentiate between symptom of oral burning and BMS.

CO2/ethylene oxide copolymerization and ligand variation for a highly active salen-cobalt(III) complex tethering 4 quaternary ammonium salts.

A cobalt(III) complex (1) of a salcy-type ligand tethering 4 quaternary ammonium salts, which is thought to act as a highly active catalyst for CO2/propylene oxide (PO) copolymerization, also shows high activity (TOF, 25,900 h(-1); TON, 518,000; 2.72 kg polymer per g cat) and selectivity (>98%) for CO2/ethylene oxide (EO) copolymerization that results in high-molecular-weight polymers (M(n), 200,000-300,000) that have strictly alternating repeating units. The related cobalt(III) complexes 11-14 were prepared through variations of the ligand framework of 1 by replacing the trans-1,2-diaminocyclohexane unit with 2,2-dimethyl-1,3-propanediamine, trans-1,2-diaminocyclopentane, or 1,1'-binaphthyl-2,2'-diamine or by replacing the aldimine bond with ketimine.

In vitro evaluation of acaricidal activity of fipronil against Haemaphysalis bispinosa based on adult immersion test.

Fipronil is a phenylpyrazole family insecticide which mainly affects the nervous system of insects. In the present study, the in vitro acaricidal effects of the compound against the widely prevalent multihost tick, Haemaphysalis bispinosa was assessed. The lowest concentration at which complete adult tick mortality was observed was at 25 ppm while complete absence of egg mass observed at 10 ppm.

Effects of solvents and surfactants against Haemaphysalis bispinosa.

As per the report published by FAO (2004), the tick population in India has developed resistance against all the available acaricides. Hence, newer methods of control including potential herbal agents are required to reduce the problems caused by the ticks. Most of the herbal extracts or their fractions are dissolved in polar or non-polar solvents or detergents before tested for acaricidal activity and these diluents should be of little acaricidal activity.

Biosurfactants as green stabilizers for the biological synthesis of nanoparticles.

Taking into consideration the needs of greener bioprocesses and novel enhancers for synthesis using microbial processes, biosurfactants, and/or biosurfactant producing microbes are emerging as an alternate source for the rapid synthesis of nanoparticles. A microemulsion technique using an oil-water-surfactant mixture was shown to be a promising approach for nanoparticle synthesis. Biosurfactants are natural surfactants derived from microbial origin composed mostly of sugar and fatty acid moieties, they have higher biodegradability, lower toxicity, and excellent biological activities.

Elucidation of the structure of a highly active catalytic system for CO2/epoxide copolymerization: a salen-cobaltate complex of an unusual binding mode.

Salen-type ligands comprised of ethylenediamine or 1,2-cyclohexenediamine, along with an salicylaldehyde bearing a methyl substituent on its 3-position and a -[CR(CH(2)CH(2)CH(2)N(+)Bu(3))(2)] (R = H or Me) on its 5-position, unexpectedly afford cobalt(III) complexes with uncoordinated imines. In these complexes, two salen-phenoxys and two 2,4-dinitrophenolates (DNPs), which counter the quaternary ammonium cations, coordinate persistently with cobalt, while two other DNPs are fluxional between a coordinated and an uncoordinated state in THF at room temperature. The complexes of this binding mode show excellent activities in carbon dioxide/propylene oxide copolymerization (TOF, 8300-13,000 h(-1)) but with some fluctuation in induction times (1-10 h), depending on how dry the system is.

InAs(x)Sb(1-x) alloy nanocrystals for use in the near infrared.

InAs(x)Sb(1-x) alloy nanocrystals for the near-infrared, which have quite a monodisperse crystalline structure of 2.5-3.0 nm and are of a zinc blend structure, are developed.